A5026135536- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Functional Brain Connectivity Studies
- Cerebrovascular and genetic disorders
- Machine Learning in Healthcare
- AI in cancer detection
- Long-Term Effects of COVID-19
- Advanced Neuroimaging Techniques and Applications
- Neurological Disorders and Treatments
- Health, Environment, Cognitive Aging
- Metabolism, Diabetes, and Cancer
- Nutritional Studies and Diet
- Moyamoya disease diagnosis and treatment
- Cardiovascular Health and Disease Prevention
- Prion Diseases and Protein Misfolding
- Blood Pressure and Hypertension Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Parkinson's Disease Mechanisms and Treatments
- Health disparities and outcomes
- Diabetes Treatment and Management
- Genomics and Rare Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
Rush University Medical Center
2016-2025
Rush University
2017-2024
Neurology, Inc
2019
Pacific Northwest National Laboratory
2018
Beth Israel Deaconess Medical Center
2017
Harvard University
2017
Tata Memorial Hospital
1992
With a rapidly aging global human population, finding cure for late onset neurodegenerative diseases has become an urgent enterprise. However, these efforts are hindered by the lack of understanding what constitutes phenotype aged microglia-the cell type that been strongly implicated genetic studies in pathogenesis age-related disease. Here, we establish set genes is preferentially expressed microglia brain. This HuMi_Aged gene captures unique phenotype, which confirm at protein level....
Abstract Emerging evidence suggests that small vessel disease (SVD) is a risk factor for clinical dementia and may contribute to AD neuropathological changes. Watershed brain regions are located at the most distal areas between arterial territories, making them vulnerable SVD-related We examined association of pathologic markers SVD, specifically arteriolosclerosis in watershed regions, with Participants ( N = 982; mean age-at-death 90; 69% women) were enrolled as part one two cohort studies...
<h3>Objective</h3> To examine the impact of 3 pathologic groups, pure limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy (LATE) neuropathologic changes (NC), Alzheimer disease change (ADNC), and mixed ADNC with LATE-NC, on late-life cognitive decline. <h3>Methods</h3> Data came from 1,356 community-based older persons who completed detailed annual testing systematic examination at autopsy to identify ADNC, other pathologies. Persons were categorized...
Background and Purpose: Enlarged perivascular spaces (EPVS) have been associated with aging, increased stroke risk, decreased cognitive function, vascular dementia. However, the relationship of EPVS age-related neuropathologies is not well understood. Therefore, purpose this study was to assess neuropathologic correlates in a large community-based cohort older adults. The over beyond those other pathologies were also assessed. Methods: This included 654 deceased autopsied participants 3...
There is increasing recognition of the importance cortical microinfarcts to overall brain health, cognition, and Alzheimer dementia. Cerebral small vessel pathologies are associated with frequently coexist disease; however, extent which Aβ (amyloid beta) tau pathology modulates microvascular pathogenesis not fully understood. Study objective was examine relationship pathologies, arteriolosclerosis, cerebral amyloid angiopathy, in people differing levels or tangle burden.Participants were...
Digital pathology (DP) has transformative potential, especially for Alzheimer disease and related disorders. However, infrastructure barriers may limit adoption. To provide benchmarks insights into implementation barriers, a survey was conducted in 2019 within National Institutes of Health's Alzheimer's Disease Centers (ADCs). Questions covered infrastructure, funding sources, data management to digital pathology. Of the 35 ADCs which sent, 33 responded. Most respondents (81%) stated that...
In this case report, we discuss a patient presenting with parkinsonism followed by non‐amnestic dementia aphasic clinical features, as well frontal dysexecutive syndrome. There was family history of an autopsy diagnosis “Pick's disease” in the proband's father. Neuroimaging revealed focal and severe temporal lobe lesser frontoparietal atrophy. At autopsy, there frontotemporal lobar degeneration. Histologic evaluation absence tau or transactivation response DNA‐binding protein 43 kDa (TDP)...
Abstract Limbic‐predominant age‐related transactive response DNA‐binding protein 43 (TDP‐43) encephalopathy neuropathologic change (LATE‐NC) and microvascular pathologies, including microinfarcts, cerebral amyloid angiopathy (CAA), arteriolosclerosis are common in old age. A relationship between LATE‐NC has been reported some but not all studies. The objectives of this study were to investigate the frequency co‐occurring pathologies test hypothesis that arteriolosclerosis, specifically, is...
Cerebrovascular disease (CVD) pathologies including vessel (atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy) tissue injury (macroinfarcts microinfarcts) each contribute to Alzheimer other forms of dementia. CVD is often a complex mix neuropathologies, with little known about the frequencies differing combinations or their associations cognition.We investigated 32 possible (3 types 2 injury) using autopsy data from 1474 decedents (≈88 years at death; 65% female) Rush...
It is not clear how common pure vascular cognitive impairment (VCI) in the absence of Alzheimer disease (AD) and/or other neurodegenerative pathologies.To identify participants without AD and pathologies determine extent to which cerebrovascular were associated with impairment.This clinical pathological study included from 2 ongoing community-based cohorts that began enrollment 1994 1997. Prior death, observed for a mean (SD) 8.4 (5.3) years annual assessments. From 2096 who died, 1799...
Abstract High-throughput digital pathology offers considerable advantages over traditional semiquantitative and manual methods of counting pathology. We used brain tissue from 5 clinical-pathologic cohort studies aging; the Religious Orders Study, Rush Memory Aging Project, Minority Research African American Clinical Core, Latino Core to (1) develop a workflow management system for processes, (2) optimize algorithms quantify Alzheimer disease (AD) pathology, (3) harmonize data statistically....
Background Lower hippocampal volume is associated with late‐life cognitive decline and an important, but nonspecific marker for clinical Alzheimer's dementia. Cerebrovascular disease may also be volume. Here we study the role of intracranial large vessel (atherosclerosis) in association potential age, average blood pressure across all visits, other factors (sex, apolipoprotein ε4 [ APOE ε4], diabetes). Methods Results Data came from 765 community‐based older people (91 years old on at death;...
Not all older adults with dementia-related neuropathology in their brains experience cognitive decline or impairment. Instead, some people maintain relatively normal functioning despite neuropathologic burden, a phenomenon called resilience. Using longitudinal, epidemiological, clinical-pathologic cohort study of the United States ( N = 348), present research investigated associations between well-being and Consistent preregistered hypotheses, results showed that higher eudaimonic (measured...
Abstract Grey matter ageing-related tau astrogliopathy (ARTAG) pathology is common in aged brains and detected multiple brain regions. However, the associations of grey ARTAG with Alzheimer's disease other age-related proteinopathies, addition to clinical phenotypes, including dementia cognitive decline, remain unclear. We examined 442 decedents (mean age at death = 90 years, males 32%) from three longitudinal community-based clinical–pathological studies. Using AT8 immunohistochemistry, was...
This study investigates the relationship between microglia inflammation in hippocampus, brain pathologies, and cognitive decline.
Transformative neuropathology is redefining human brain research by integrating foundational descriptive pathology with advanced methodologies to drive discoveries that inform diagnostics, therapeutics, and disease prevention. These approaches, spanning multi-omics studies machine learning applications, enable the identification of biomarkers, therapeutic targets, complex patterns through comprehensive analyses postmortem tissue. Yet critical challenges, including sustainability banks,...
BACKGROUND: Few neuropathologic studies focus on the associations of cerebrovascular pathologies with cognition in older Black adults. METHODS: We conducted a nested substudy participants who were enrolled 1 4 harmonized longitudinal cohort studies—the Minority Aging Research Study, African American Clinical Core, Rush Memory and Project, Religious Order Study before coming to autopsy. Neuropathologic evaluation included assessment neurodegenerative pathologies. first documented single mixed...
Importance: Molecular mechanisms linking neuroticism with Alzheimer's disease traits are unknown. Objective: To identify molecular subtypes of and examine their association ADRD traits. Design: Three ongoing cohort studies were used; Religious Orders Study (ROS), Rush Memory Aging Project (MAP) Minority Research (MARS), that began enrollment in 1994, 1997, 2004, respectively. Setting: Older priests, nuns, brothers from across the U.S. older adults African-American (MARS) greater Chicago...