Hilary W. Heuer
A5007616908- Amyotrophic Lateral Sclerosis Research
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Visual perception and processing mechanisms
- Genetic Neurodegenerative Diseases
- Prion Diseases and Protein Misfolding
- Cerebral Palsy and Movement Disorders
- Neurological diseases and metabolism
- Folate and B Vitamins Research
- Neurological disorders and treatments
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Cholinesterase and Neurodegenerative Diseases
- Neurological Disease Mechanisms and Treatments
- Genomics and Rare Diseases
- Neurobiology of Language and Bilingualism
- Delphi Technique in Research
- Medical Research and Treatments
- Epilepsy research and treatment
- Older Adults Driving Studies
University of California, San Francisco
2016-2025
University Memory and Aging Center
2016-2025
VIB-UAntwerp Center for Molecular Neurology
2024
University of Antwerp
2024
University of California, Los Angeles
2022-2024
Universidad Católica de Santa Fe
2020-2024
Liechtenstein Institute
2023
Hudson Institute
2023
John Wiley & Sons (United States)
2023
Harvard University
2013-2022
Receptive fields (RFs) of cells in the middle temporal area (MT or V5) monkeys will often encompass multiple objects under normal image viewing. We therefore have studied how moving stimuli interact when presented within and near RF single MT cells. used Gabor function stimuli, <1 degrees spatial extent approximately 100 msec duration, on a grid possible locations over cell. Responses to these were typically robust, their small allowed detailed mapping RFs interactions between stimuli. The...
<h3>Background</h3> Elevated CSF τ is considered a biomarker of neuronal injury in newly developed Alzheimer9s disease (AD) and mild cognitive impairment (MCI) criteria. However, previous studies have failed to detect alterations species other primary tauopathies. We assessed protein abnormalities AD, tauopathy with prominent Aβ pathology, progressive supranuclear palsy (PSP), characterised by deposition four microtubule-binding repeat (4R) minimal pathology. <h3>Methods</h3> 26 normal...
Abstract Introduction We created global rating scoring rules for the CDR ® plus NACC FTLD to detect and track early frontotemporal lobar degeneration (FTLD) conduct clinical trials in FTLD. Methods The was applied 970 sporadic familial participants from baseline visit of Advancing Research Treatment Frontotemporal Lobar Degeneration (ARTFL)/Longitudinal Evaluation Familial Dementia Subjects (LEFFTDS). Each eight domains equally weighed determining score. An interrater reliability study...
<h3>Objective:</h3> To examine the utility and reliability of volumetric MRI in measuring disease progression 4 repeat tauopathies, progressive supranuclear palsy (PSP) corticobasal syndrome (CBS), to support clinical development new tau-directed therapeutic agents. <h3>Methods:</h3> Six- 12-month changes regional volumes PSP Rating Scale scores were examined 55 patients with 33 CBS (78% amyloid PET negative) compared 30 normal controls from a multicenter natural history study. Longitudinal...
We tested the hypothesis that plasma neurofilament light chain (NfL) identifies asymptomatic carriers of familial frontotemporal lobar degeneration (FTLD)-causing mutations at risk disease progression.Baseline NfL concentrations were measured with single-molecule array in original (n = 277) and validation 297) cohorts. C9orf72, GRN, MAPT mutation noncarriers from same families classified by severity (asymptomatic, prodromal, full phenotype) using CDR Dementia Staging Instrument plus behavior...
At present, no research criteria exist for the diagnosis of prodromal behavioural variant frontotemporal dementia (bvFTD), though early detection is high importance. Thus, we sought to develop and validate a proposed set bvFTD, termed 'mild and/or cognitive impairment in bvFTD' (MBCI-FTD). Participants included 72 participants deemed have bvFTD; this comprised 55 carriers pathogenic mutation known cause lobar degeneration, 17 individuals with autopsy-confirmed degeneration. All had mild...
Abstract Despite recent advances in fluid biomarker research Alzheimer’s disease (AD), there are no biomarkers or imaging tracers with utility for diagnosis and/or theragnosis available other tauopathies. Using immunoprecipitation and mass spectrometry, we show that 4 repeat (4R) isoform-specific tau species from microtubule-binding region (MTBR-tau 275 MTBR-tau 282 ) increase the brains of corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), frontotemporal lobar (FTLD)-...
Frontotemporal dementia (FTD) therapy development is hamstrung by a lack of susceptibility, diagnostic, and prognostic biomarkers. Blood neurofilament light (NfL) shows promise as biomarker, but studies have largely focused only on core FTD syndromes, often grouping patients with different diagnoses. To expedite the clinical translation NfL, we avail ARTFL LEFFTDS Longitudinal Lobar Degeneration (ALLFTD) study resources conduct comprehensive investigation plasma NfL across syndromes in...
Importance Frontotemporal lobar degeneration (FTLD) is relatively rare, behavioral and motor symptoms increase travel burden, standard neuropsychological tests are not sensitive to early-stage disease. Remote smartphone-based cognitive assessments could mitigate these barriers trial recruitment success, but no such tools validated for FTLD. Objective To evaluate the reliability validity of measures remote FTLD evaluations. Design, Setting, Participants In this cohort study conducted from...
Importance Blood-based biomarkers for Alzheimer disease (AD) are clinically available, but their value is not well understood in syndromes typically associated with frontotemporal lobar degeneration (FTLD). Objective To investigate the clinical importance and detectability of AD FTLD-related neurodegenerative using 3 plasma biomarkers, phosphorylated tau 217 (p-tau217), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP). Design, Setting, Participants This...
Contrast normalization is a process whereby responses of neurons are scaled according to the total amount contrast in region image nearby receptive field neuron. This allows code for informative scene or object attributes manner unaffected by changes illumination. Evidence seen striate and extrastriate cortex from experiments where multiple stimuli presented with single (RF). Neuronal such smaller than that predicted linear summation, revealing presence normalization. While often clear, its...
Deficits in the generation and control of saccades have been described clinically defined frontotemporal dementia (FTD) Alzheimer disease (AD).To determine saccade abnormalities associated with autopsy-defined cases lobar degeneration (FTLD) AD, because clinical FTD syndromes can correspond to a number different underlying neuropathologic non-FTD diagnoses.An infrared eye tracker was used record visually guided 10° targets antisaccades subjects autopsy-confirmed mean (SE) 35.6 (10.0) months...
Progressive supranuclear palsy (PSP) has been conceptualized as a large-scale network disruption, but the specific targeted not fully characterized. We sought to delineate affected in patients with clinical PSP.
<h3>Objective:</h3> The aims of this study were to examine executive dysfunction using an antisaccade (AS) task in normal elderly (NE) and patients with mild cognitive impairment (MCI) Alzheimer disease (AD) as well evaluate the relationship between AS performance cortical thinning within AD-associated regions. <h3>Methods:</h3> We recorded eye movements 182 subjects (NE: 118; MCI: 36; AD: 28) during task. also performed neuropsychological measures function for comparison. Brain MRI scans...
Behavior/Comportment/Personality (BEHAV) and Language (LANG) domains were added to the Clinical Dementia Rating (CDR®) for improving evaluation of patients with frontotemporal lobar degeneration (FTLD) (CDR® plus NACC FTLD).
The Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) Longitudinal Evaluation of Familial Dementia Subjects (LEFFTDS) consortia are two closely connected studies, involving multiple North American centers that evaluate both sporadic familial frontotemporal dementia (FTD) participants study longitudinal changes.
Sleep disturbance is common among patients with neurodegenerative diseases. Examining the subcortical neuronal correlates of sleep disturbances important to understanding early-stage phenomena.
<h3>Importance</h3> The accurate diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) is hampered by imperfect clinical-pathological correlations. <h3>Objective</h3> To assess compare the diagnostic value magnetic resonance parkinsonism index (MRPI) other imaging–based measures cerebral atrophy to differentiate between PSP, CBD, neurodegenerative diseases. <h3>Design, Setting, Participants</h3> This prospective study included participants with 4-repeat...