A5032162810- Neurobiology of Language and Bilingualism
- Action Observation and Synchronization
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Language, Metaphor, and Cognition
- Face Recognition and Perception
- Neural dynamics and brain function
- Aesthetic Perception and Analysis
- Multisensory perception and integration
- Child and Animal Learning Development
- Creativity in Education and Neuroscience
- Advanced MRI Techniques and Applications
- Memory and Neural Mechanisms
- Mental Health Research Topics
- Amyotrophic Lateral Sclerosis Research
- EEG and Brain-Computer Interfaces
- Neuroscience and Music Perception
- Health, Environment, Cognitive Aging
- Educational and Psychological Assessments
- Alzheimer's disease research and treatments
- Olfactory and Sensory Function Studies
- Parkinson's Disease Mechanisms and Treatments
- Cerebral Palsy and Movement Disorders
Bangor University
2018-2025
Neuroscience Institute
2023
University of Manchester
2010-2018
University of California, San Francisco
2013-2018
Temple University
2014-2018
University Memory and Aging Center
2015-2017
Stanford University
2016
Massachusetts General Hospital
2016
Harvard University
2016
Occupational Cancer Research Centre
2016
Although there is an emerging consensus that the anterior temporal lobes (ATLs) are involved in semantic memory, it currently unclear which specific parts of this region implicated representation. Answers to question difficult glean from existing literature for 3 reasons: 1) lesions relevant patient groups tend encompass whole ATL region; 2) while local effects repetitive transcranial magnetic stimulation (rTMS) spatially more specific, only lateral aspects available stimulation; and 3)...
Abstract In recent years, multiple independent neuroscience investigations have implicated critical roles for the rostral temporal lobe in auditory and visual perception, language, semantic memory. Although arising context of different cognitive functions, most these suggest that there is a gradual convergence sensory information culminates modality- perceptually invariant representations at aspect. Currently, however, too little known regarding connectivity within human to be sure exactly...
Semantic cognition is underpinned by regions involved in representing conceptual knowledge and executive control areas that provide regulation of this information according to current task requirements. Using distortion-corrected fMRI, we investigated the contributions these two systems abstract concrete word comprehension. We contrasted semantic decisions made either with coherent contextual support, which encouraged retrieval a rich representation, or irrelevant information, instead...
Significance Functional neuroimaging has established that most cognitive functions are supported by distributed neural networks. Hundreds of studies have investigated the semantic network (SN) and default mode (DMN) (neural deactivation when undertaking a variety tasks). These stable networks increasingly used as biomarkers in neurological psychiatric investigations. Despite implicating overlapping regions shared mechanisms, relationship between two received minimal attention. Analyses large...
Abstract Impaired social cognition is a core deficit in frontotemporal dementia (FTD). It most commonly associated with the behavioural-variant of FTD, atrophy orbitofrontal and ventromedial prefrontal cortex. Social cognitive changes are also common semantic dementia, centred on anterior temporal lobes. The impairment behaviour FTD has typically been attributed to damage cortex and/or poles uncinate fasciculus that connects them. However, relative contributions each region unresolved. In...
In primary progressive aphasia (PPA), speech and language difficulties are caused by neurodegeneration of specific brain networks. the nonfluent/agrammatic variant (nfvPPA), motor grammatical deficits associated with atrophy in a left fronto-insular-striatal network previously implicated production. vivo dissection crossing white matter (WM) tracts within this "speech production network" is complex has rarely been performed health or PPA. We hypothesized that damage to these would be nfvPPA...
We provide novel evidence of specific clinical and neuroimaging features that may help for the in vivo prediction underlying pathology patients with nonfluent/agrammatic primary progressive aphasia (nfvPPA) supranuclear palsy (PSP) or corticobasal degeneration (CBD) proved by autopsy.To characterize neurological, cognitive, nfvPPA-in whom either PSP CBD was eventually confirmed at autopsy-at initial presentation 1-year follow-up.A prospective longitudinal clinical-pathological study...
A growing body of recent convergent evidence indicates that the anterior temporal lobe (ATL) has connectivity-derived graded differences in semantic function: ventrolateral region appears to be transmodal, omni-category center-point hub whilst secondary contributions come from peripheries a manner reflects their differential connectivity different input/output modalities. One key challenges for this neurocognitive theory is how types concept, especially those with less reliance upon external...
Human higher cognition arises from the main tertiary association cortices including frontal, temporal and parietal lobes. Many studies have suggested that cortical functions must be shaped or emerge pattern of underlying physical (white matter) connectivity. Despite importance this hypothesis, there has not been a large-scale analysis white-matter connectivity within between these associative cortices. Thus, we explored intra- inter-lobe white matter multiple areas defined in each lobe. We...
Neurodegeneration has been hypothesized to follow predetermined large-scale networks through the trans-synaptic spread of toxic proteins from a syndrome-specific epicentre. To date, no longitudinal neuroimaging study tested this hypothesis in vivo frontotemporal dementia spectrum disorders. The aim was demonstrate that progression atrophy non-fluent/agrammatic variant primary progressive aphasia spreads over time epicentre additional regions, based on their connectivity healthy control...
The anterior temporal lobes (ATLs) play a key role in conceptual knowledge representation. hub-and-spoke theory suggests that the contribution of ATLs to semantic representation is (a) transmodal, i.e. integrating information from multiple sensorimotor and verbal modalities, (b) pan-categorical, representing concepts all categories. Another literature, however, this region's responses are modality- category-selective; prominent examples include category selectivity for socially relevant face...
<h3>Objective:</h3> To examine the utility and reliability of volumetric MRI in measuring disease progression 4 repeat tauopathies, progressive supranuclear palsy (PSP) corticobasal syndrome (CBS), to support clinical development new tau-directed therapeutic agents. <h3>Methods:</h3> Six- 12-month changes regional volumes PSP Rating Scale scores were examined 55 patients with 33 CBS (78% amyloid PET negative) compared 30 normal controls from a multicenter natural history study. Longitudinal...
It has been proposed that social experience plays an important role in the grounding of concepts, and socialness proffered as a fundamental organisational principle underpinning semantic representation human brain. However, empirical support for these hypotheses is limited by inconsistencies way defined measured. To further advance theory, field must establish clearer working definition, research efforts could be facilitated availability extensive set ratings individual concepts. Therefore,...
Multiple representation theories posit that concepts are represented via a combination of properties derived from sensorimotor, affective, and linguistic experiences. Recently, it has been proposed information social experience, or socialness, represents another key aspect conceptual representation. How these various dimensions interact to form coherent space yet be fully explored. To address this, we capitalized on openly available word property norms for 6339 words conducted large-scale...
Preregistration is the act of formally documenting a research plan before collecting (or at least analysing) data. It allows those reading final report to know which aspects study were decided sight data, and added later. This enables informed evaluation severity with scientific claims have been tested. We, as British Neuropsychological Society Open Science Group, conducted survey explore awareness adoption open science practices within our field. Neuropsychology involves relatively rare or...
By developing and applying a method which combines fMRI rTMS to explore semantic cognition, we identified both intrinsic (related automatic changes in task/stimulus-related processing) induced (i.e., associated with the effect of TMS) activation core, functionally-coupled network elements. Low-frequency applied human anterior temporal lobe (ATL) induced: (a) local suppression at site stimulation; (b) remote three other ipsilateral regions; (c) compensatory up-regulation contralateral ATL....
Wernicke’s aphasia occurs after a stroke to classical language comprehension regions in the left temporoparietal cortex. Consequently, auditory–verbal is significantly impaired but capacity comprehend visually presented materials (written words and pictures) partially spared. This study used functional magnetic resonance imaging investigate neural basis of written word picture semantic processing aphasia, with wider aim examining how system altered damage regions. Twelve participants chronic...
Contemporary theories of semantic representation posit that social experience is an important source information for deriving meaning. However, there a lack behavioral evidence in support this proposal. The aim the present work was to test whether words' degree relevance, or
A key challenge for neurobiological models of social cognition is to elucidate whether brain regions are specialised that domain. In recent years, discussion surrounding the role anterior temporal epitomises such debates; some argue lobe (ATL) part a domain-specific network processing, while others claim it comprises domain-general hub semantic representation. present study, we used ATL-optimised fMRI map contribution different ATL structures variety paradigms frequently probe crucial...