A5090742144- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Nuclear reactor physics and engineering
- Nuclear Physics and Applications
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Mental Health Research Topics
- Neural dynamics and brain function
- Neurobiology of Language and Bilingualism
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Cerebrospinal fluid and hydrocephalus
- Psychosomatic Disorders and Their Treatments
- Graphite, nuclear technology, radiation studies
- Heart Rate Variability and Autonomic Control
- Genetic Neurodegenerative Diseases
- Health, Environment, Cognitive Aging
- Neonatal and fetal brain pathology
- Neurological Disease Mechanisms and Treatments
- Nuclear Materials and Properties
- Epilepsy research and treatment
University Memory and Aging Center
2015-2024
University of California, San Francisco
2015-2024
Oak Ridge National Laboratory
2021-2023
Liechtenstein Institute
2023
Hudson Institute
2023
John Wiley & Sons (United States)
2023
Institut des Sciences Cognitives Marc Jeannerod
2021
University of Puerto Rico System
2020
Northwestern University
2020
University of Brescia
2020
Tau imaging with [ 18 F]flortaucipir predicts the severity and topography of subsequent MRI cortical atrophy in patients Alzheimer’s disease.
Structural and functional underconnectivity have been reported for multiple brain regions, systems, white matter tracts in individuals with autism spectrum disorders (ASD). Although recent developments complex network analysis established that the is a modular exhibiting small-world properties, level organization has not carefully examined ASD. Here we used resting-state MRI (n = 42 ASD, n 37 typically developing; TD) to show children adolescents ASD display reduced short long-range...
Accurately predicting the underlying neuropathological diagnosis in patients with behavioural variant frontotemporal dementia (bvFTD) poses a daunting challenge for clinicians but will be critical success of disease-modifying therapies. We sought to improve pathological prediction by exploring clinicopathological correlations large bvFTD cohort. Among 438 whom was either top or an alternative possible clinical diagnosis, 117 had available autopsy data, including 98 primary lobar degeneration...
The default mode network (DMN) supports memory functioning and may be sensitive to preclinical Alzheimer's pathology. Little is known, however, about the longitudinal trajectory of this network's intrinsic functional connectivity (FC). In study, we evaluated FC in 111 cognitively normal older human adults (ages 49-87, 46 women/65 men), 92 whom had at least three task-free fMRI scans (n = 353 total scans). Whole-brain DMN subnetworks were assessed: (1) within-DMN, (2) between anterior...
Old age and possession of the APOE -4 allele are two main risk factors for developing later onset Alzheimer's Disease (AD). Carriers have known differences in intrinsic functional brain network activity across life span. These individuals also demonstrate specific regional gray white matter gross structure. However, relationship these variations to whole structural connectivity remains unclear. We performed diffusion tensor imaging (DTI), T1 imaging, cognitive testing on aging noncarriers (...
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Attention deficit hyperactivity disorder (ADHD) currently is diagnosed in children by clinicians via subjective ADHD-specific behavioral instruments and reports from the parents teachers. Considering its high prevalence large economic societal costs, a quantitative tool that aids diagnosis characterizing underlying neurobiology would be extremely valuable. This provided motivation for ADHD-200 machine learning (ML) competition, multisite collaborative effort to investigate imaging...
Brain connectomics research has rapidly expanded using functional MRI (fMRI) and diffusion-weighted (dwMRI). A common product of these varied analyses is a connectivity matrix (CM). CM stores the connection strength between any two regions ("nodes") in brain network. This format useful for several reasons: (1) it highly distilled, with minimal data size complexity, (2) graph theory can be applied to characterize network's topology, (3) retains sufficient information capture individual...
The human brain undergoes dramatic maturational changes during late stages of fetal and early postnatal life. importance this period to the establishment healthy neural connectivity is apparent in high incidence injury preterm infants, whom untimely exposure ex-uterine factors interrupts connectivity. Though relevance neuroscience apparent, little known about functional networks Here, we apply graph theoretical analysis examine Utilizing resting state magnetic resonance imaging (fMRI) data...
Neurodegeneration has been hypothesized to follow predetermined large-scale networks through the trans-synaptic spread of toxic proteins from a syndrome-specific epicentre. To date, no longitudinal neuroimaging study tested this hypothesis in vivo frontotemporal dementia spectrum disorders. The aim was demonstrate that progression atrophy non-fluent/agrammatic variant primary progressive aphasia spreads over time epicentre additional regions, based on their connectivity healthy control...
<h3>Importance</h3> Basket-design clinical trials that allow investigation of treatment effects on different syndromes share the same molecular pathophysiology have not previously been attempted in neurodegenerative disease. <h3>Objective</h3> To assess safety, tolerability, and pharmacodynamics microtubule stabilizer TPI-287 (abeotaxane) Alzheimer disease (AD) or 4-repeat tauopathies (4RT) progressive supranuclear palsy (PSP) corticobasal syndrome (CBS). <h3>Design, Setting,...
In a clinical setting, an individual subject classification model rather than group analysis would be more informative. Specifically, the subtlety of cortical atrophy in some frontotemporal dementia (FTD) patients and overlapping patterns among three FTD syndromes including behavioral variant (bvFTD), non-fluent/agrammatic primary progressive aphasia (nfvPPA), semantic PPA (svPPA) give rise to need for models at level. this study, we aimed classify each into one diagnostic categories...
According to the network model of neurodegeneration, spread pathogenic proteins occurs selectively along connected brain regions. We tested in vivo whether distribution filamentous tau (measured with [18F]flortaucipir-PET), fibrillar amyloid-β ([11C]PIB-PET) and glucose hypometabolism ([18F]FDG-PET) follows intrinsic functional organization healthy brain. included 63 patients Alzheimer's disease (AD; 30 male, ± 8 years) who underwent [18F]flortaucipir, [11C]PIB [18F]FDG PET, 1000 young...
Recently, carriers of a common variant in the autism risk gene, CNTNAP2, were found to have altered functional brain connectivity using MRI. Here, we scanned 328 young adults with high-field (4-Tesla) diffusion imaging, test hypothesis that this gene would structural connectivity. All participants (209 women, 119 men, age: 23.4±2.17 SD years) 105-gradient high-angular-resolution imaging (HARDI) at 4 Tesla. After performing whole-brain fiber tractography full angular resolution scans, 70...
Despite increasing emphasis on the potential of dietary antioxidants in preventing memory loss and diet as a precursor neurological health, rigorous studies investigating cognitive effects foods their components are rare. Recent animal have reported other benefits polyphenols, found abundantly pomegranate juice. We performed preliminary, placebo-controlled randomized trial juice older subjects with age-associated complaints using testing functional brain activation (fMRI) outcome measures....
The salience network is a distributed neural system that maintains homeostasis by regulating autonomic nervous activity and social-emotional function. Here we examined how within-network connectivity relates to individual differences in human (including males females) baseline parasympathetic sympathetic activity. We measured resting physiology 24 healthy controls 23 patients with behavioral variant frontotemporal dementia (bvFTD), neurodegenerative disease characterized deficits....
Abstract One of the challenges brain network analysis is to directly compare organization between subjects, irrespective number or strength connections. In this study, we used minimum spanning tree (MST; a unique, acyclic subnetwork with fixed connections) characterize human create an empirical reference network. Such could be as null model connections that form backbone structure brain. We analyzed MST in three diffusion‐weighted imaging datasets healthy adults. The group mean connectivity...