A5027327338- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Neurobiology of Language and Bilingualism
- Psychosomatic Disorders and Their Treatments
- Mental Health and Psychiatry
- Face Recognition and Perception
- Alzheimer's disease research and treatments
- EEG and Brain-Computer Interfaces
- Action Observation and Synchronization
- Mental Health Treatment and Access
- Memory and Neural Mechanisms
- Autism Spectrum Disorder Research
- Family Caregiving in Mental Illness
- Child and Adolescent Psychosocial and Emotional Development
- Schizophrenia research and treatment
- Olfactory and Sensory Function Studies
- Heart Rate Variability and Autonomic Control
- Pediatric Pain Management Techniques
- Musculoskeletal pain and rehabilitation
- Treatment of Major Depression
- Cerebral Palsy and Movement Disorders
- Advanced Neuroimaging Techniques and Applications
- Medicinal Plants and Bioactive Compounds
- Amyotrophic Lateral Sclerosis Research
- Mental Health Research Topics
University of California, Berkeley
2017-2024
University of California, San Francisco
2015-2023
University Memory and Aging Center
2016-2023
Berkeley College
2021
Samsung Medical Center
2018
Sungkyunkwan University
2018
Institute on Aging
2018
University of Pennsylvania
2018
Center for Neurosciences
2017
Yale University
2016
Abstract Focal anterior temporal lobe degeneration often preferentially affects the left or right hemisphere. While patients with left-predominant atrophy show severe anomia and verbal semantic deficits meet criteria for variant primary progressive aphasia dementia, early are more difficult to diagnose as their symptoms less well understood. is associated prominent emotional behavioural changes, meet, go on frontotemporal dementia. Uncertainty around absence of an overarching...
Significance Brain–body interactions are fundamental to physical and mental health. Here, we used a unique brain lesion model elucidate the neural localization lateralization of cerebro-cardiac control. Our data revealed that salience network, an intrinsic connectivity network anchored by anterior insula cingulate, is crucial for maintaining basal parasympathetic outflow. Specifically, dominant hemisphere-predominant damage undermined control heart. The findings suggest balanced functional...
The salience network is a distributed neural system that maintains homeostasis by regulating autonomic nervous activity and social-emotional function. Here we examined how within-network connectivity relates to individual differences in human (including males females) baseline parasympathetic sympathetic activity. We measured resting physiology 24 healthy controls 23 patients with behavioral variant frontotemporal dementia (bvFTD), neurodegenerative disease characterized deficits....
Affective changes precede cognitive decline in mild Alzheimer's disease and may relate to increased connectivity a "salience network" attuned emotionally significant stimuli. The trajectory of affective preclinical disease, its relationship this network, is unknown.One hundred one cognitively normal older adults received longitudinal assessments symptoms, then amyloid-PET. We hypothesized amyloid-positive individuals would show enhanced emotional reactivity associated with salience network...
To examine clinicopathologic correlations in early vs late age at onset frontotemporal dementia (FTD) and lobar degeneration (FTLD).All patients were clinically evaluated prospectively diagnosed the UCSF Memory Aging Center. Two consecutive series included: (1) with a FTD syndrome who underwent autopsy (cohort 1) (2) primary pathologic diagnosis of FTLD, regardless clinical 2). These divided by symptom (cutoff 65 years).In cohort 1, 48 (25.3%) years or older onset. Pathologic causes...
Progressive supranuclear palsy syndrome (PSP-S) results from neurodegeneration within a network of brainstem, subcortical, frontal and parietal cortical brain regions. It is unclear how dysfunction progresses relates to longitudinal atrophy clinical decline. In this study, we evaluated patients with PSP-S (n = 12) healthy control subjects 20) at baseline 6 months later. Subjects underwent structural MRI task-free functional (tf-fMRI) scans evaluations both time points. At baseline, voxel...
Caregiving for a person with dementia or neurodegenerative disease is associated increased rates of depression and anxiety. As the population ages prevalence increases worldwide, mental health problems related to caregiving will become an even more pressing public concern. In present study, we assessed emotional empathy (physiological, behavioral, self-reported responses film depicting others suffering) two measures cognitive (identifying primary emotion experienced by another providing...
Abstract Introduction Empathy and shared feelings of reward motivate individuals to share resources with others when material gain is not at stake. Behavioral variant frontotemporal dementia (bv FTD ) a neurodegenerative disease that affects emotion‐ reward‐relevant neural systems. Although there diminished empathy altered processing in bv , how the impacts prosocial behavior less well understood. Methods A total 74 participants (20 15 Alzheimer's [ AD ], 39 healthy controls) participated...
Behavioral variant frontotemporal dementia (bvFTD) is a neurodegenerative disease characterized by profound changes in emotions and empathy. Although most patients with bvFTD become less sensitive to negative emotional cues, some more positive stimuli. We investigated whether dysregulated undermine empathy making it difficult for share (emotional empathy), recognize (cognitive respond (real-world empathy) others. Fifty-one participants (26 25 healthy controls) viewed photographs of neutral,...
Abstract Deficits in emotion perception (the ability to infer others’ emotions accurately) can occur as a result of neurodegeneration. It remains unclear how different neurodegenerative diseases affect forms perception. The present study compares performance on dynamic tracking task (where participants track the changing valence film character’s emotions) with an category labeling label specific portrayed by characters) across seven diagnostic groups (N = 178) including Alzheimer’s disease...
Empathic accuracy, the ability to accurately understand other people’s emotions, is typically viewed as beneficial for mental health. However, empathic accuracy may be problematic when a close relational partner depressed because it promotes shared depression. Across two studies, we measured using laboratory tasks that capture rate emotional valence over time: first in sample of 156 neurotypical married couples (Study 1; total N = 312), and then 102 informal caregivers individuals with...
In semantic dementia (SD), asymmetric degeneration of the anterior temporal lobes is associated with loss knowledge and alterations in socioemotional behavior. There are two clinical variants SD: variant primary progressive aphasia (svPPA), which characterized by predominant atrophy lobe insula left hemisphere, behavioral frontotemporal (sbvFTD), those structures right hemisphere. Previous studies dementia, an syndrome that targets frontal insula, have found impairments baseline autonomic...
Caregivers of patients with neurodegenerative diseases are at heightened risk for serious health problems, but differences between individual caregivers abound.
Abstract Frontotemporal dementia (FTD), a neurodegenerative disease broadly characterized by socioemotional impairments, includes three clinical subtypes: behavioral variant FTD (bvFTD), semantic primary progressive aphasia (svPPA) and non-fluent (nfvPPA). Emerging evidence has shown emotional reactivity impairments in bvFTD svPPA, whereas nfvPPA is far less studied. In 105 patients with (49 bvFTD, 31 svPPA 25 nfvPPA) 27 healthy controls, we examined aspects of (physiology, facial behavior...
Motivated by the high rates of health problems found among caregivers persons with neurodegenerative disease, we examined associations between deficits in two aspects care recipients' socioemotional functioning and their caregivers' health. In 2 studies independent samples (N = 171 73 dyads), reported on emotion recognition emotional reactivity. Caregiver was assessed using both self-report measures (Studies 1 2) autonomic nervous system indices (Study 2). Lower recipients linearly...
Caregivers of persons with neurodegenerative disease have high rates mental health problems compared to noncaregiving adults. Emotion regulation may play an important role in preserving caregivers' health. We examined the associations between emotion measured several ways (ability, habitual use, and self-ratings) their symptoms.Ninety-one caregivers participated a laboratory-based assessment regulation. In two series tasks, were given different instructions (no instruction, suppress)...
Researchers typically study physiological responses either after stimulus onset or when the emotional valence of an upcoming is revealed. Yet, participants may also respond they are told that about to be presented even without knowing its valence. Increased responding during this time reflect a 'preparation for action'. The generation such supported by frontotemporal regions brain vulnerable damage in lobar degeneration. We examined preparatory and their structural functional neural...
Subjective emotional experience that is congruent with a given situation (i.e., target emotions) critical for human survival (e.g., feeling disgusted in response to contaminated food motivates withdrawal behaviors). Neurodegenerative diseases including frontotemporal dementia and Alzheimer's disease affect brain regions cognitive functioning, resulting increased of emotions incongruent the non-target emotions, such as happy when seeing someone grieving). We examined neuroanatomical...
Assessing the numbers and distribution of at-risk megafauna such as black rhino (Diceros bicornis) is key to effective conservation, yet data are difficult obtain. Many current monitoring technologies invasive target animals expensive. Satellite emerging a potential tool for very large (e.g., elephant) but detecting smaller species requires higher resolution imaging. Drones can deliver required speed monitoring, challenges remain in delivering automated systems where internet connectivity...
Abstract Neurodegenerative diseases lead to deficits in cognitive functioning that could disrupt the ability perceive others’ emotions. We examined whether semantic knowledge and executive function relate two aspects of emotion perception. Individuals with frontotemporal dementia healthy controls (N = 110; 33 behavioral variant, 23 non-fluent 30 24 controls) completed tests word (Peabody Picture Vocabulary Test Boston Naming Test) (Digit Span Backwards, Stroop, Design Fluency, Trail-Making)....
OBJECTIVE: To determine whether there is baseline autonomic nervous system dysfunction in behavioral variant frontotemporal dementia (bvFTD) and to examine deficits relate cognitive empathy impairment. BACKGROUND: bvFTD a neurodegenerative disease that impacts the neural systems support emotion social behavior. Although patients with have diminished reactivity certain emotional contexts, extent which less well understood. Deficits sympathetic parasympathetic functioning may interfere...