A5084736757- Cardiovascular Health and Disease Prevention
- Dementia and Cognitive Impairment Research
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Neurological Disorders and Treatments
- Optical Imaging and Spectroscopy Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Acute Ischemic Stroke Management
- Angiogenesis and VEGF in Cancer
- Spatial Neglect and Hemispheric Dysfunction
- Neurobiology of Language and Bilingualism
- Glycosylation and Glycoproteins Research
- Cardiovascular Health and Risk Factors
- Psychosomatic Disorders and Their Treatments
- Advanced Neuroimaging Techniques and Applications
- Health, Environment, Cognitive Aging
- Cerebrovascular and genetic disorders
- Neurogenesis and neuroplasticity mechanisms
University of Southern California
2019-2025
University of California, San Francisco
2018-2025
University Memory and Aging Center
2018-2025
Southern California University for Professional Studies
2020-2024
University of California, Irvine
2022
ORCID
2020
Samsung Medical Center
2018
Sungkyunkwan University
2018
Institute on Aging
2018
University of Pennsylvania
2018
Aging into later life is often accompanied by social disconnection, anxiety, and sadness. Negative emotions are self-focused states with detrimental effects on aging longevity. Awe-a positive emotion elicited when in the presence of vast things not immediately understood-reduces self-focus, promotes connection, fosters prosocial actions encouraging a "small self." We investigated emotional benefits novel "awe walk" intervention healthy older adults. Sixty participants took weekly 15-min...
<h3>Background and Objectives</h3> Blood pressure variability is an emerging risk factor for cognitive decline dementia, but mechanisms remain unclear. The current study examined whether visit-to-visit blood related to CSF Alzheimer disease biomarker levels over time associations differed by <i>APOE</i> ε4 carrier status. <h3>Methods</h3> In this retrospective analysis of a prospective cohort study, cognitively unimpaired or mildly impaired older adults from the Alzheimer9s Disease...
To examine clinicopathologic correlations in early vs late age at onset frontotemporal dementia (FTD) and lobar degeneration (FTLD).All patients were clinically evaluated prospectively diagnosed the UCSF Memory Aging Center. Two consecutive series included: (1) with a FTD syndrome who underwent autopsy (cohort 1) (2) primary pathologic diagnosis of FTLD, regardless clinical 2). These divided by symptom (cutoff 65 years).In cohort 1, 48 (25.3%) years or older onset. Pathologic causes...
Background: Recent observational studies suggest higher blood pressure (BP) variability (BPV) is associated with Alzheimer’s disease (AD) biomarkers amyloid-beta (Aβ) and tau. Less known about relationships in interventional cohorts strictly controlled mean BP levels. Objective: Investigate the longitudinal relationship between BPV change plasma AD under standard versus intensive treatment. Methods: In this post hoc analysis of SPRINT trial, 457 participants (n = 206 group, n 251 group)...
Background: Blood pressure variability is linked to Alzheimer’s disease (AD) risk and MRI-based markers of cerebrovascular disease. Less known about the role blood in postmortem evaluation AD. Objective: To determine whether antemortem predicts AD pathology follow-up cognitive change autopsy-confirmed Methods: National Coordinating Center participants (n = 513) underwent 3-4 approximately annual measurements were confirmed have at evaluation. A subset 493) neuropsychological follow-up....
Abstract BACKGROUND Elevated blood pressure (BP) variability is predictive of increased risk for stroke, cerebrovascular disease, and other vascular brain injuries, independent traditionally studied average BP levels. However, no studies to date have evaluated whether related diminished reactivity, which may represent an early marker dysfunction presaging injury. METHODS The present study investigated reactivity in a sample 41 community-dwelling older adults (mean age 69.6 [SD 8.7] years)...
Background Blood pressure variability (BPV) is predictive of cerebrovascular disease and dementia, possibly though cerebral hypoperfusion. Higher BPV associated with blood flow (CBF) decline in observational cohorts, but relationships samples strictly controlled remain understudied. We investigated whether relates to change CBF the context intensive versus standard antihypertensive treatment. Methods Results In this post hoc analysis SPRINT MIND (Systolic Pressure Intervention Trial-Memory...
Cerebrovascular reactivity (CVR) represents the ability of cerebral blood vessels to regulate flow in response vasoactive stimuli and is related cognition cerebrovascular neurodegenerative conditions. However, few studies have examined CVR medial temporal lobe, known be affected early Alzheimer disease influence memory function. We aimed examine whether associated with function older adults without mild cognitive impairment (MCI). In this observational study, independently living free...
Abstract Vascular Endothelial Growth Factor A (VEGF-A) is an angiogenic signaling protein involved in the maintenance of cerebral vasculature. No prior study has explored whether plasma VEGF-A levels may be associated with brain functional connectivity changes, such as disruption default mode network (DMN), which often precedes development cognitive changes aging. Seventy-six independently living older adults (mean age = 70.3 years; SD 7.5; 31.6% male) free dementia or clinical stroke...
APOE4 carriers at genetic risk for Alzheimer's disease exhibit early cerebrovascular dysfunction, which may be triggered by endothelial dysfunction. Endothelial progenitor cells (EPCs) represent cell populations involved in promoting angiogenesis and facilitating vascular repair response to injury. We examined whether elevated EPCs are associated with lower cerebral small vessel burden prior cognitive decline. Independently living older adults (N = 109, mean age 70.5 years; SD 7.9; 34.9 %...
Background : Dementia risk is significantly shaped by cardiovascular health, with elevated blood pressure emerging as a key factor for adverse brain aging. Blood biomarkers such pTau181, Aβ42/40, NfL, and GFAP have improved our understanding of dementia pathophysiology, however, few studies explored how specific metrics relate to biomarker levels, which could inform personalized prevention strategies these move into clinic. We examined different associated molecular markers astrocytic...
Abstract Background Dementia risk is significantly shaped by cardiovascular health, with elevated blood pressure emerging as a key factor for adverse brain aging. Blood biomarkers such pTau181, Aβ42/40, NfL, and GFAP have improved our understanding of dementia pathophysiology, however, few studies explored how specific metrics relate to biomarker levels, which could inform personalized prevention strategies these move into clinic. We examined different associated molecular markers astrocytic...
Background: Elevated blood pressure variability (BPV) is predictive of dementia, independent average levels, but neuropathological mechanisms remain unclear. We examined whether BPV in older adults related to tau accumulation brain regions vulnerable Alzheimer disease and relationships are modified by apoϵ4 carrier status. Methods: Two hundred eighty-six Alzheimer’s Disease Neuroimaging Initiative participants without history dementia underwent 3 4 measurements over 12 months ≥1 positron...
Background: Cerebral small vessel disease (SVD) is associated with increased risk of stroke and dementia. Progressive damage to the cerebral microvasculature may also trigger angiogenic processes promote repair. Elevated levels circulating endothelial progenitor cells (EPCs) pro-angiogenic signaling proteins are observed in response vascular injury. We aimed examine EPCs proangiogenic older adults evidence SVD. Methods: Older (ages 55-90) free dementia or underwent venipuncture brain...
Blood pressure variability is an emerging risk factor for stroke, cognitive impairment, and dementia, possibly through links with cerebral hypoperfusion. Recent evidence suggests visit-to-visit (e.g., over months, years) blood related to perfusion decline in brain regions vulnerable Alzheimer's disease. However, less known about relationships between short-term <24 h) regional perfusion, whether these may differ by age. We investigated concurrent microvascular a sample of community-dwelling...
Abstract Blood pressure variability is an emerging risk factor for Alzheimer’s disease in older adults, independent of average blood levels. Growing evidence suggests increased linked to pathophysiology indexed by cerebrospinal fluid and positron emission tomography markers, but relationships with plasma markers have not been investigated. In this cross-sectional study 54 community-dwelling adults (aged 55–88, mean age 69.9 [8.2 SD]), elevated over 5 min was associated lower levels Aβ 1–42...
Blood pressure variability (BPV) is emerging as an important risk factor across numerous disease states, including cerebrovascular and neurodegenerative in older adults. However, there no current consensus regarding specific use cases for the available BPV metrics. There also little published data supporting ability to reliably measure metrics were derived from continuous beat-to-beat blood monitoring data. Two sequential 7-minute waveforms analyzed. Absolute relative reliability testing was...
Behavioral variant frontotemporal dementia (bvFTD) is a neurodegenerative disease characterized by profound changes in emotions and empathy. Although most patients with bvFTD become less sensitive to negative emotional cues, some more positive stimuli. We investigated whether dysregulated undermine empathy making it difficult for share (emotional empathy), recognize (cognitive respond (real-world empathy) others. Fifty-one participants (26 25 healthy controls) viewed photographs of neutral,...
Elevated blood pressure is linked to cognitive impairment and Alzheimer's disease (AD) biomarker abnormality. However, levels vary over time. Less known about the role of long-term variability in AD pathophysiology.