A5102909044- Alzheimer's disease research and treatments
- Heart Rate Variability and Autonomic Control
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Spine and Intervertebral Disc Pathology
- Intracerebral and Subarachnoid Hemorrhage Research
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular and Laser Science Research
- Retinal and Optic Conditions
- Pain Management and Treatment
- Scoliosis diagnosis and treatment
- Neuroscience of respiration and sleep
- Tryptophan and brain disorders
- Ocular Infections and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- EEG and Brain-Computer Interfaces
- Neurological Disease Mechanisms and Treatments
- Physical Activity and Health
- Cerebrovascular and Carotid Artery Diseases
- Pain Mechanisms and Treatments
Center for Innovation
2022-2025
University of Arizona
2022-2025
Arizona Science Center
2023-2025
Beaumont Hospital, Royal Oak
1990
Higher order regulation of autonomic function is maintained by the coordinated activity specific cortical and subcortical brain regions, collectively referred to as central network (CAN). Autonomic changes are frequently observed in Alzheimer's disease (AD) dementia, but no studies date have investigated whether plasma AD biomarkers associated with CAN functional connectivity at risk older adults.
Cerebrovascular reactivity (CVR) represents the ability of cerebral blood vessels to regulate flow in response vasoactive stimuli and is related cognition cerebrovascular neurodegenerative conditions. However, few studies have examined CVR medial temporal lobe, known be affected early Alzheimer disease influence memory function. We aimed examine whether associated with function older adults without mild cognitive impairment (MCI). In this observational study, independently living free...
Amyotrophic lateral sclerosis (ALS) continues to pose a significant challenge due the disease complexity and heterogeneous manifestations. Despite recent drug approvals, there remains critical need for development of more effective therapies. This review explores underlying mechanisms involved; including neuroinflammation, glutamate mediated excitotoxicity, mitochondrial dysfunction, hypermetabolism, how researchers are trying develop novel drugs target these pathways. While progress has...
Blood pressure variability is increasingly linked with cerebrovascular disease and Alzheimer's disease, independent of mean blood levels. Elevated also associated attenuated reactivity, which may have implications for functional hyperemia underpinning brain network connectivity. It remains unclear whether related to We examined relationships between beat-to-beat connectivity in networks vulnerable aging disease. 53 community-dwelling older adults (mean [SD] age = 69.9 [7.5] years, 62.3%...
Abstract Background Increased blood pressure variability (BPV) is a risk factor for cerebral small vessel disease (CSVD) and neurodegeneration, independent of age average pressure, particularly in apolipoprotein E4 ( APOE4 ) carriers. However, it remains uncertain whether BPV elevation cause or consequence vascular brain injury, to what degree injury the central autonomic network (CAN) may contribute BPV-associated Methods Independently living older adults (n=70) with no history stroke...
We report a case of Listeria monocytogenes endophthalmitis that presented as recalcitrant keratouveitis in nonimmunocompromized patient. L. was recovered from the patient's aqueous, vitreous, and two three blood cultures. He treated with topical, sub-conjunctival, systemic antibiotics, but visual outcome poor, possibly because late diagnosis. A review previous cases demonstrates unique features this infection: (a) presentation an anterior uveitis or elevated intraocular pressure, (b)...
Study Design. Human cadaveric lumbar spines were used to assess the temperature and thermal dose distribution during intradiscal electrothermal therapy in vitro. Objectives. To determine whether produces adequate tissue temperatures denature annular collagen or ablate nerve cells. Summary of Background Data. Several hypothesized mechanisms for effect have been suggested include: 1) shrinkage nucleus and/or annulus fibrosus by contraction fibers; 2) ablation sensitive fibers outer annulus....
Abstract Apolipoprotein E ε4 allele (APOE4) is the predominant genetic risk factor for late-onset Alzheimer’s disease (AD). APOE4 mouse models have provided advances in understanding of pathogenesis, but unaccounted variables like rodent housing status may hinder translational outcomes. Non-sterile aspects food and bedding can be major sources changes microflora. Alterations intestinal microbial ecology cause mucosal barrier impairment increase pro-inflammatory signals. The present study...
Abstract Visit-to-visit blood pressure variability (BPV) predicts age-related hippocampal atrophy, neurodegeneration, and memory decline in older adults. Beat-to-beat BPV may represent a more reliable efficient tool for prospective risk assessment, but it is unknown whether beat-to-beat similarly associated with or plasma markers of neuroaxonal/neuroglial injury. Independently living adults without history dementia, stroke, other major neurological disorders were recruited from the community...
Abstract Background APOE4 carriers exhibit cerebrovascular dysfunction which may contribute to the development of cognitive decline and dementia; however, mechanisms underlying this pathophysiology remain unknown. Impaired reactivity (CVR) be associated with vascular injury, inflammation, endothelial dysfunction. To examine whether these processes involved in CVR deficits carriers, we explored plasma levels injury markers indicative inflammation are impaired hypercapnia hypocapnia older...
Abstract Background Higher order regulation of autonomic function is maintained by cortical and subcortical interconnected regions within the brain, collectively referred to as central network (CAN) (Benarroch, 1993). Despite well‐established relationship between dysfunction AD (Femminella et al., 2014) CAN functional connectivity biomarkers AD, such Ab 42/40 ratio, remains unexplored. Methods 76 independently living older adults were recruited from community undergo brain fMRI venipuncture....
Study Design. Retrospective study of consecutive patient series. Objectives. To review the radiographic and clinical results patients with preoperative fixed sagittal imbalance treated combined anterior posterior arthrodesis, to determine factors that predict outcome. Summary Background Data. Combined arthrodesis spine is useful in management deformity involving coronal planes. The specific indications for surgery regional global have not been well defined. Methods. 25 spinal arthrodesis....
Abstract Background Perivascular spaces (PVS) are fluid‐filled surrounding arterioles, capillaries and venules in the brain, which support metabolic waste clearance. Enlarged PVS associated with increased dementia risk. Changes arterial pulsatility hypothesized to be accumulation of toxic solutes widening. However, few prior studies have examined whether cerebral blood flow (CBF) is linked PVS. Method Independently living older adults (N = 60, mean age 68.1 years; SD 7.5; range 55‐88 30.0%...
Abstract Background Perivascular spaces (PVS) are fluid‐filled surrounding arterioles, capillaries and venules in the brain, which support metabolic waste clearance. Enlarged PVS associated with increased dementia risk. Changes arterial pulsatility hypothesized to be accumulation of toxic solutes widening. However, few prior studies have examined whether cerebral blood flow (CBF) is linked PVS. Method Independently living older adults (N = 60, mean age 68.1 years; SD 7.5; range 55‐88 30.0%...