A5040623189- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Functional Brain Connectivity Studies
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- S100 Proteins and Annexins
- MRI in cancer diagnosis
- Brain Tumor Detection and Classification
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury Research
- Cerebrovascular and genetic disorders
- Ethics in medical practice
- Viral Infections and Immunology Research
- Vagus Nerve Stimulation Research
- Tactile and Sensory Interactions
- Health Systems, Economic Evaluations, Quality of Life
- Inflammatory Myopathies and Dermatomyositis
- Nicotinic Acetylcholine Receptors Study
- EEG and Brain-Computer Interfaces
Surgical Specialties (United States)
2022
University of California, San Francisco
2017-2020
University of California, Berkeley
2017-2020
Sheba Medical Center
2020
University Memory and Aging Center
2019
Hope Center for Neurological Disorders
2017
Lawrence Berkeley National Laboratory
2017
University of Colorado Anschutz Medical Campus
2015
Southern California University for Professional Studies
2015
University of Southern California
2015
Tau imaging with [ 18 F]flortaucipir predicts the severity and topography of subsequent MRI cortical atrophy in patients Alzheimer’s disease.
The tau positron emission tomography (PET) ligand 18F-flortaucipir binds to paired helical filaments of in aging and Alzheimer's disease (AD), but its utility detecting aggregates frontotemporal dementia (FTD) is uncertain. We performed imaging patients with the FTD syndromes (n = 45): nonfluent variant primary progressive aphasia (nfvPPA) 11), corticobasal syndrome (CBS) 10), behavioral (bvFTD) semantic (svPPA) 2) associated pathogenic genetic mutations microtubule-associated protein (MAPT)...
<h3>Objective</h3> To assess the relationships between fluid and imaging biomarkers of tau pathology compare their diagnostic utility in a clinically heterogeneous sample. <h3>Methods</h3> Fifty-three patients (28 with clinical Alzheimer disease [AD] 25 non-AD neurodegenerative diagnoses) underwent β-amyloid (Aβ) ([<sup>18</sup>F]AV1451) PET lumbar puncture. CSF (Aβ<sub>42</sub>, total [t-tau], phosphorylated [p-tau]) were measured by multianalyte immunoassay (AlzBio3). Receiver operator...
<h3>Objective</h3> To assess whether Alzheimer disease (AD) clinical presentation and <i>APOE4</i> relate to the burden topography of β-amyloid (Aβ) tau pathologies using in vivo PET imaging. <h3>Methods</h3> We studied 119 Aβ-positive symptomatic patients aged 48–95 years, including 29 with logopenic variant primary progressive aphasia (lvPPA) 21 posterior cortical atrophy (PCA). Pittsburgh compound B (PiB)–Aβ flortaucipir (tau)–PET standardized uptake value ratio (SUVR) images were...
To characterize individual and group-level neuroimaging findings in patients at risk for Chronic Traumatic Encephalopathy (CTE). Eleven male meeting criteria Syndrome (TES, median age: 64) underwent neurologic evaluation, 3-Tesla MRI, PET with [18F]-Flortaucipir (FTP, tau-PET) [11C]-Pittsburgh compound B (PIB, amyloid-PET). Six [18F]-Fluorodeoxyglucose-PET (FDG, glucose metabolism). We assessed imaging the patient level, comparisons modality-specific groups of cognitively normal older adults...
We aimed to assess whether β-amyloid (PIB) and tau (AV1451) PET predict longitudinal atrophy in patients with AD. A group of 10 fulfilling NIA-AA criteria for AD dementia likely due were included (age = 63 ± 9, MMSE 24 4 at baseline). All underwent i) a baseline visit structural MRI imaging both AV1451 PIB, ii) follow-up (time between MRIs 1.06 0.15 years). Structural images preprocessed using SPM12's registration pipeline obtain voxelwise maps showing areas local contractions expansions...
We aimed to assess whether β-amyloid (PIB) and tau (AV1451) PET predict longitudinal atrophy in patients with AD. A group of 10 fulfilling NIA-AA criteria for AD dementia likely due were included (age = 63 ± 9, MMSE 24 4 at baseline). All underwent i) a baseline visit structural MRI imaging both AV1451 PIB, ii) follow-up (time between MRIs 1.06 0.15 years). Structural images preprocessed using SPM12's registration pipeline obtain voxelwise maps showing areas local contractions expansions...
Hypothetical models of the evolution Alzheimer's disease (AD) biomarkers predict a non-linear, sigmoid model. However, it is still unclear whether better fit model than linear for progression amyloid, tau, and neurodegeneration across AD spectrum. [11C]PiB-, [18F]AV1451-PET, 3T T1-weighted MRI were obtained 110 subjects, including 49 cognitively normal controls (33 PiB-, 16 PiB+), 61 PiB+ patients (12 MCI, AD) (Table 1). PiB 35-90min DVR AV1451 80-100min SUVR images created using cerebellar...
Abstract Background The high cognitive and anatomical heterogeneity in phenotypical variants of Alzheimer’s Disease imposes a formidable challenge for biomarker‐based discriminatory models. Motivated by recent findings (La Joie, 2020) suggesting causal relationship between regional tau accumulation future atrophy development, we used Machine Learning techniques to test whether colocalization these two biomarkers could improve clinical differentiation AD variants. Method We investigated 85...
Thanks to recent radiotracer developments, both PET imaging and fluid biomarkers can now be used assess AD pathophysiological mechanisms in vivo, notably tau pathology. The present study aims determine the relationships between tau-PET using 18F-AV1451 cerebrospinal (CSF) a heterogeneous sample of patients encompassing non-AD etiologies. We studied seen at UCSF Memory Aging Center with available AV1451-PET, PIB-PET CSF (median lumbar puncture: 114 days). This included 19 PIB-positive 13...
The apolipoprotein E (APOE) ε4 allele is associated with an increase in Aβ pathology; yet, suspected to have additional Aβ-independent effects on AD pathophysiology. Here, we aimed assess potential of tau pathology using PET imaging [18F]AV1451 and [11C]PIB. Two cohorts were studied: i) a group 71 cognitively normal elders, ii) 44 clinically impaired PIB-positive patients (patients MCI or at the dementia stage), see Table 1 for demographics. data processed Freesurfer 5.3 SPM12 compute...
The apolipoprotein E (APOE) ε4 allele is associated with an increase in Aβ pathology; yet, suspected to have additional Aβ-independent effects on AD pathophysiology. Here, we aimed assess potential of tau pathology using PET imaging [18F]AV1451 and [11C]PIB. Two cohorts were studied: i) a group 71 cognitively normal elders, ii) 44 clinically impaired PIB-positive patients (patients MCI or at the dementia stage), see Table 1 for demographics. data processed Freesurfer 5.3 SPM12 compute...
The apolipoprotein E (APOE) ε4 allele is associated with an increase in Aβ pathology; yet, suspected to have additional Aβ-independent effects on AD pathophysiology. Here, we aimed assess potential of tau pathology using PET imaging [18F]AV1451 and [11C]PIB. Two cohorts were studied: i) a group 71 cognitively normal elders, ii) 44 clinically impaired PIB-positive patients (patients MCI or at the dementia stage), see Table 1 for demographics. data processed Freesurfer 5.3 SPM12 compute...
Thanks to recent radiotracer developments, both PET imaging and fluid biomarkers can now be used assess AD pathophysiological mechanisms in vivo, notably tau pathology. The present study aims determine the relationships between tau-PET using 18F-AV1451 cerebrospinal (CSF) a heterogeneous sample of patients encompassing non-AD etiologies. We studied seen at UCSF Memory Aging Center with available AV1451-PET, PIB-PET CSF (median lumbar puncture: 114 days). This included 19 PIB-positive 13...
The factors underlying AD 'atypical variants' (e.g. early symptom onset or non-amnestic phenotypes) are poorly understood. We aimed to relate a patient's clinical presentation of AD, age, and APOE genotype the amount topography β-amyloid tau pathologies using positron emission tomography (PET) with PIB Flortaucipir. studied 86 patients diagnosis dementia MCI due positive PIB-PET (Table 1), including 17 who also met criteria for logopenic variant primary progressive aphasia (lvPPA, i.e....
The risk factors that underlie sporadic early-onset Alzheimer's disease (sEOAD) are not well understood. We compared clinical presentation, demographic features, ApoE genotype, and dementia between patients with non-autosomal AD in without a family history of the disease. A group 103 sEOAD ≤64 age onset confirmed evidence amyloidosis using available PIB-PET or CSF values were included. Patients known APP/PSEN1/PSEN2 mutations excluded. Pedigrees reviewed participants classified as: (1) no...
Neurodegeneration in Alzheimer's disease appears more closely related to regional deposition of tau than amyloid. What is unclear how local and global combine drive subsequent atrophy. Here we tested whether a network-based model could improve our prediction longitudinal gray matter atrophy based on baseline Flortaucipir PET scan. 21 patients who met NIA-AA criteria for AD dementia likely due were studied (age = 63 ± 9, MMSE 24 4 at baseline). At baseline, received structural MRI scans PIB....
Hypothetical models of the evolution Alzheimer's disease (AD) biomarkers predict a non-linear, sigmoid model. However, it is still unclear whether better fit model than linear for progression amyloid, tau, and neurodegeneration across AD spectrum. [11C]PiB-, [18F]AV1451-PET, 3T T1-weighted MRI were obtained 110 subjects, including 49 cognitively normal controls (33 PiB-, 16 PiB+), 61 PiB+ patients (12 MCI, AD) (Table1). PiB 35-90min DVR AV1451 80-100min SUVR images created using cerebellar...
The factors underlying AD 'atypical variants' (e.g. early symptom onset or non-amnestic phenotypes) are poorly understood. We aimed to relate a patient's clinical presentation of AD, age, and APOE genotype the amount topography β-amyloid tau pathologies using positron emission tomography (PET) with PIB Flortaucipir. studied 86 patients diagnosis dementia MCI due positive PIB-PET (Table 1), including 17 who also met criteria for logopenic variant primary progressive aphasia (lvPPA, i.e....
Neurodegeneration in Alzheimer's Disease appears more closely related to regional deposition of tau than amyloid. What is unclear how local and global combine drive subsequent atrophy. Here we tested whether a network-based model could improve our prediction longitudinal gray matter atrophy based on baseline Flortaucipir PET scan. 21 patients who met NIA-AA criteria for AD dementia likely due were studied (age = 63 ± 9, MMSE 24 4 at baseline). At baseline, received structural MRI scans PIB....