A5082140726- Functional Brain Connectivity Studies
- Motor Control and Adaptation
- Neural dynamics and brain function
- Action Observation and Synchronization
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Muscle activation and electromyography studies
- Parkinson's Disease Mechanisms and Treatments
- Visual perception and processing mechanisms
- Transcranial Magnetic Stimulation Studies
- Face Recognition and Perception
- Medical Imaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Heart Rate Variability and Autonomic Control
- Mental Health Research Topics
- Vestibular and auditory disorders
- Memory and Neural Mechanisms
- Sport Psychology and Performance
- Non-Invasive Vital Sign Monitoring
- Genetic Neurodegenerative Diseases
- Neuroscience and Music Perception
- Child and Animal Learning Development
University of California, Santa Barbara
2015-2024
Research Network (United States)
2024
Hologic (Germany)
2024
Brain (Germany)
2024
Biopac (United Kingdom)
2023
Institute for Collaborative Biotechnologies
2009-2022
University of California, San Francisco
2022
University of California, Santa Cruz
2020
Imaging Center
2009-2018
University of Cambridge
2015
Despite evidence pointing to a ubiquitous tendency of human minds wander, little is known about the neural operations that support this core component cognition. Using both thought sampling and brain imaging, current investigation demonstrated mind-wandering associated with activity in default network cortical regions are active when "at rest." In addition, individuals' reports their wander were correlated network.
Human learning is a complex phenomenon requiring flexibility to adapt existing brain function and precision in selecting new neurophysiological activities drive desired behavior. These two attributes—flexibility selection—must operate over multiple temporal scales as performance of skill changes from being slow challenging fast automatic. Such selective adaptability naturally provided by modular structure, which plays critical role evolution, development, optimal network function. Using...
Purpose Our goal was to validate linear and nonlinear intersubject image registration using an automated method (AIR 3.0) based on voxel intensity. Method PET MRI data from 22 normal subjects were registered corresponding averaged or brain atlases several specific spatial transformation models with algorithm. Validation anatomically defined landmarks. Results Automated produced results that superior a manual nine parameter variant of the Talairach method. Increasing degrees freedom in model...
Abstract Cognitive function is driven by dynamic interactions between large-scale neural circuits or networks, enabling behaviour. However, fundamental principles constraining these network processes have remained elusive. Here we use tools from control and theories to offer a mechanistic explanation for how the brain moves cognitive states drawn organization of white matter microstructure. Our results suggest that densely connected areas, particularly in default mode system, facilitate...
Patients with Parkinson's disease tend to have a reduced response levodopa after 5 20 years of therapy, "on—off" fluctuations consisting dyskinesia alternating immobility. In an effort modify the motor disability advanced disease, we implanted embryonic mesencephalic tissue containing dopamine cells into caudate and putamen seven patients. Two patients received unilateral grafts in on side opposite worse symptoms. Five bilateral only. six patients, fetal was obtained from single embryo...
The brain localization of motor sequence learning was studied in normal subjects with positron emission tomography. Subjects performed a serial reaction time (SRT) task by responding to series stimuli that occurred at four different spatial positions. stimulus locations were either determined randomly or according 6-element cycled continuously. SRT under two conditions. With attentional interference from secondary counting there no development awareness the sequence. Learning-related...
Magnetic resonance imaging enables the noninvasive mapping of both anatomical white matter connectivity and dynamic patterns neural activity in human brain. We examine relationship between structural properties streamlines (structural connectivity) functional correlations (functional within 84 healthy subjects at rest during performance attention- memory-demanding tasks. show that properties, including length, number, spatial location streamlines, are indicative can be inferred from strength...
Determining the relationship between mechanisms involved in action planning and/or execution is critical to understanding neural bases of skilled behaviors, including tool use. Here we report findings from two fMRI studies healthy, right-handed adults which an event-related design was used distinguish regions (i.e. identifying, retrieving and preparing actions associated with a familiar tools' uses) versus executing use gestures dominant right (experiment 1) non-dominant left 2) hands. For...
We describe techniques for the robust detection of community structure in some classes time-dependent networks. Specifically, we consider use statistical null models facilitating principled identification structural modules semi-decomposable systems. Null play an important role both optimization quality functions such as modularity and subsequent assessment validity identified structure. examine sensitivity methods to model parameters show how comparisons can help identify system scales. By...
Human motor skills can be acquired by observation without the benefit of immediate physical practice. The current study tested if rehearsal and observational learning share common neural substrates within an action network (AON) including premotor inferior parietal regions, that is, areas activated both for execution similar actions. Participants trained 5 days on dance sequences set to music videos. Each day they physically rehearsed one (“danced”), passively watched a different...
When a child reaches toward cookie, the watching parent knows immediately what wants. The neural basis of this ability to interpret other people’s actions in terms their goals has been subject much speculation. Research with infants shown that 6 month olds respond when they see an adult reach novel goal but habituate same repeatedly. We used similar approach event-related functional magnetic resonance imaging experiment. Adult participants observed series movies depicting goal-directed...
As a person learns new skill, distinct synapses, brain regions, and circuits are engaged change over time. In this paper, we develop methods to examine patterns of correlated activity across large set regions. Our goal is identify properties that enable robust learning motor skill. We measure during sequencing characterize network based on coherent between Using recently developed algorithms detect time-evolving communities, find the complex reconfiguration brain's putative functional...