A5054771538- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- Visual perception and processing mechanisms
- Vestibular and auditory disorders
- Pain Management and Treatment
- Neural and Behavioral Psychology Studies
- Neurobiology of Language and Bilingualism
- Muscle activation and electromyography studies
- Vagus Nerve Stimulation Research
- Metabolism and Genetic Disorders
- Spatial Neglect and Hemispheric Dysfunction
- Motor Control and Adaptation
- Hemispheric Asymmetry in Neuroscience
- Diet and metabolism studies
- Advanced Neuroimaging Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Ophthalmology and Eye Disorders
- Glycogen Storage Diseases and Myoclonus
Emory University
2009-2022
University of Split
2016
Stanford University
2016
Albert Einstein College of Medicine
2016
Montefiore Medical Center
2016
Hospital for Special Surgery
2016
King Faisal Specialist Hospital & Research Centre
2016
Palomar Medical Center
2016
Emory University Hospital
1983-2012
Atlanta VA Medical Center
1992-2006
We report a multicenter, double-blind, randomized trial of bilateral stimulation the anterior nuclei thalamus for localization-related epilepsy.Participants were adults with medically refractory partial seizures, including secondarily generalized seizures. Half received and half no during 3-month blinded phase; then all unblinded stimulation.One hundred ten participants randomized. Baseline monthly median seizure frequency was 19.5. In last month phase stimulated group had 29% greater...
To report long-term efficacy and safety results of the SANTE trial investigating deep brain stimulation anterior nucleus thalamus (ANT) for treatment localization-related epilepsy.This follow-up is a continuation previously reported 5- vs 0-V ANT stimulation. Long-term began 13 months after device implantation with parameters adjusted at investigators' discretion. Seizure frequency was determined using daily seizure diaries.The median percent reduction from baseline 1 year 41%, 69% 5 years....
Summary: Purpose: Left cervical vagus nerve stimulation (VNS) decreases complex partial seizures (CPS) by unknown mechanisms of action. We hypothesized that therapeutic VNS alters synaptic activities at vagal afferent terminations and in sites receive polysynaptic projections from these medullary nuclei. Methods: Ten patients with epilepsy underwent positron emission tomographic (PET) measurements cerebral blood flow (BF) three times before during VNS. Parameters for were high levels 5 low...
Rapid-rate transcranial magnetic stimulation (rTMS) allows for the noninvasive examination of cerebral cortex. Recent studies have begun to investigate whether rTMS may be therapeutic treatment depression. In present study, authors report on safety and efficacy in treating 50 patients with refractory Overall, there were 21 responders (42%). Interestingly, 56% young responded, but only 23% elderly responded rTMS. was well tolerated all patients. Specifically, no patient developed a new onset...
To determine possible sites of therapeutic action vagus nerve stimulation (VNS), by correlating acute VNS-induced regional cerebral blood flow (rCBF) alterations and chronic responses.We previously found that VNS acutely induces rCBF at receive vagal afferents higher-order projections, including dorsal medulla, somatosensory cortex (contralateral to stimulation), thalamus cerebellum bilaterally, several limbic structures (including hippocampus amygdala bilaterally).VNS-induced changes were...
Magnetic stimulation of the human brain is performed in clinical and research settings, but site activation has not been clearly localized humans or other species. We used a set magnetic stimulus coils with different field profiles to isolate movement single digits at motor threshold calculate corresponding electric strengths various distances beneath scalp. Two could produce same intensity only 1 point. Thus, we estimate depth by finding intersection plots, which were then superimposed on...
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique to induce electric currents in the brain. Although rTMS being evaluated as possible alternative electroconvulsive therapy for treatment of refractory depression, little known about pattern activation induced brain by rTMS. We have compared immediate early gene expression rat after and stimulation, well-established animal model therapy. Our result shows that applied conditions effective models depression induces...
Abstract A family is described with familial myoclonic epilepsy associated mitochondrial myopathy. The disorder follows a maternal inheritance pattern consistent DNA (mtDNA) mutation. large kindred permitted exclusion of autosomal dominant, recessive, and X‐linked patterns transmission. Several characteristics the inheriatnce variability expression within pedigree are recently acquired knowledge about genetics human mtDNA. clilnical spectrum disease compatible proportionality model mutant...
Rapid-rate transcranial magnetic brain stimulation produces lateralized suppression of speech output over the frontal lobe, consistent with cerebral dominance for language. But sensitivity localization has been limited, and reports are imprecise concerning amount discomfort involved. Using a focal coil, we evaluated effectiveness pain at different intensities, orientations, repetition rates (2 to 32 Hz) in six normal volunteers. We obtained complete clearly arrest all subjects. The best...
Background: Repetitive transcranial magnetic stimulation (rTMS) has shown safety and efficacy for treatment-resistant depression, but requires daily treatment 4–6 weeks. Accelerated TMS, with all treatments delivered over a few days, would have significant advantages in terms of access patient acceptance. Methods: Open-label accelerated TMS (aTMS), consisting 15 rTMS sessions administered 2 was tested 14 depressed patients not responding to at least one antidepressant medication. Effects on...
Motor evoked potentials (MEPs) are electrical signals recorded from neural tissue or muscle after activation of central motor pathways. They complement other clinical neurophysiology techniques, such as somatosensory (SEPs), in the assessment nervous system, especially during intraoperative neurophysiologic monitoring (IONM). Somatosensory directly assess only a part spinal cord, dorsal columns (Emerson, 1988), and also medial lemniscus, thalamocortical radiations, cortex. Because they...
To examine outcomes at age 4.5 years and compare to earlier ages in children with fetal antiepileptic drug (AED) exposure.The NEAD Study is an ongoing prospective observational multicenter study, which enrolled pregnant women epilepsy on AED monotherapy (1999-2004) determine if differential long-term neurodevelopmental effects exist across 4 commonly used AEDs (carbamazepine, lamotrigine, phenytoin, or valproate). The primary outcome IQ 6 of age. Planned analyses were conducted using Bayley...
TRANSCRANIAL magnetic stimulation (TMS) is a noninvasive technique for investigating brain function that uses pulsed fields created by special coils to induce localized neuronal depolarization. Despite the technique's expanding application, exact field produced TMS have never been directly measured in human subjects. Using standard 1.5T MR scanner and constructed from non materials, we obtained 3D maps of volunteers. Further, mapped combined two demonstrated combinations might be used focus...
Summary: Purpose: To measure vagus nerve stimulation (VNS)‐induced cerebral blood flow (CBF) effects after prolonged VNS and to compare these with immediate on CBF. Methods: Ten consenting partial epilepsy patients had positron emission tomography (PET) intravenous [ 15 O]H 2 O. Each three control scans without during 30 s of VNS, within 20 h began (immediate‐effect study), repeated 3 months (prolonged study). After intrasubject subtraction from scans, images were anatomically transformed...
A number of studies have linked the blood oxygenation level dependent (BOLD) signal to electroencephalographic (EEG) signals in traditional frequency bands (δ, θ, α, β, and γ), but relationship between BOLD its direct correlates infraslow band (<1 Hz) has been little studied. Previously, work rodents showed that local field potentials play a role functional connectivity, particularly dynamic organization large-scale networks. To examine activity network dynamics humans, current (DC) EEG...
Summary Transcranial magnetic stimulation requires a great deal of power, which mandates bulky power supplies and produces rapid coil heating. The authors describe the construction, modeling, testing an iron-core TMS that reduces requirements heat generation substantially, while improving penetration field. Experimental measurements numeric boundary element analysis show induces much stronger electrical fields, allows greater charge recovery, generates less than air-core counterparts when...
A prospective study compared psychiatric, neurocognitive, and quality-of-life changes of heart liver transplant patients. The 51 61 candidates recipients completed the Beck depression inventory (BDI), state-trait anxiety (STAI), sickness impact profile (SIP), mini-mental state (MMS), California verbal learning test (CVLT), Wisconsin card sorting (WCST), trailmaking (TMT), message (IMI). Data were gathered before at 3-month intervals for up to 1 year after transplant. Psychometric tests...