A5077116235- Pain Management and Treatment
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Epilepsy research and treatment
- Neuroscience and Neural Engineering
- Blind Source Separation Techniques
- Neurological disorders and treatments
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Fractal and DNA sequence analysis
- Neural Networks and Applications
- Laser Applications in Dentistry and Medicine
- Stroke Rehabilitation and Recovery
- Functional Brain Connectivity Studies
- Complex Systems and Time Series Analysis
- Chaos control and synchronization
- Muscle activation and electromyography studies
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Power System Optimization and Stability
- Advanced MRI Techniques and Applications
- Nerve Injury and Rehabilitation
- Magnetic Properties and Applications
Boston Scientific (United States)
2017-2024
International Neuromodulation Society
2017-2023
Boston Scientific (Netherlands)
2022-2023
Neuromod (Ireland)
2022
NeuroPace (United States)
2005-2021
University of Alabama at Birmingham
2017-2018
Harvard University
2016
University of Toronto
2016
Hospital for Sick Children
2016
Medical University of South Carolina
2016
The fractal dimension of a waveform represents powerful tool for transient detection. In particular, in analysis electroencephalograms and electrocardiograms, this feature has been used to identify distinguish specific states physiologic function. A variety algorithms are available the computation dimension. study, most common methods estimating biomedical signals directly time domain (considering series as geometric object) analyzed compared. is performed over both synthetic data...
A signal feature with low computational burden is presented as an efficient tool for seizure onset detection. The was evaluated over a total of. 1,215 hours of intracranial EEG from 10 patients. Results confirmed this being useful detection yielding average delay 4.1 seconds, 0.051 false positives per hour, and one negative on subclinical out 111 seizures analyzed which 23 were subclinical.
<h3>Objective:</h3> To evaluate the sensitivity of quantitative EEG (QEEG) for electrographic seizure identification in intensive care unit (ICU). <h3>Methods:</h3> Six-hour epochs chosen from 15 patients underwent transformation into QEEG displays. Each epoch was reviewed 3 formats: raw EEG, + raw, and QEEG-only. Epochs were also analyzed by a proprietary detection algorithm. Nine neurophysiologists EEGs to identify seizures serve as gold standard. other with experience evaluated formats,...
Pain is a multidimensional experience mediated by distributed neural networks in the brain. To study this phenomenon, EEGs were collected from 20 subjects with chronic lumbar radiculopathy, age and gender matched healthy subjects, 17 pain scheduled to receive an implanted spinal cord stimulator. Analysis of power spectral density, coherence, phase-amplitude coupling using conventional statistics showed that there no significant differences between radiculopathy control groups after...
Abstract Spinal cord stimulation (SCS) evokes fast epidural evoked compound action potential (ECAP) that represent activity of dorsal column axons, but not necessarily a spinal circuit response. Using multimodal approach, we identified and characterized delayed slower by SCS reflects synaptic within the cord. Anesthetized female Sprague Dawley rats were implanted with an lead, motor cortex electrodes, recording intraspinal penetrating electrode array, intramuscular electromyography (EMG)...
Brief bursts of focal, low amplitude rhythmic activity have been observed on depth electroencephalogram (EEG) in the minutes before electrographic onset seizures human mesial temporal lobe epilepsy. We found these periods to contain discrete, individualized synchronized patient-specific frequency bands ranging from 20 40 Hz. present a method for detecting and displaying events using periodogram sign-limited derivative EEG signal, denoted joint sign event characterization transform (JSPECT)....
Low-frequency (<200 Hz), subperception spinal cord stimulation (SCS) is a novel modality demonstrating therapeutic efficacy for treating chronic neuropathic pain. When parameters were carefully titrated, patients experienced rapid onset (seconds-minutes) pain relief without paresthesia, but the mechanisms of action are unknown. Using an integrated computational model and in vivo measurements urethane-anesthetized rats, we quantified how (placement, pulse width, frequency, amplitude)...
Spinal cord stimulation (SCS) utilizing time-dynamic pulses (TDPs) is an emergent field of neuromodulation that continuously and automatically modulates pulse parameters. We previously demonstrated TDPs delivered for 60 min at paresthesia-free or minimal paresthesia amplitudes significantly reversed allodynia in a rat model neuropathic pain. Because the anti-allodynic effect was observed to persist post-stimulation, we hypothesized anti-nociceptive effects may longer than those tonic...
The fractal dimension (FD) of a waveform represents powerful tool for transient detection. In particular, in analysis electroencephalograms (EEG) and electrocardiograms (EGG), this feature has been used to identify distinguish specific states physiologic function. A variety algorithms are available the computation FD. study, most common methods estimating FD biomedical signals analyzed compared. is performed over both synthetic data intracranial EEG (IEEG) recorded during pre-surgical...
We present a quantitative method for identifying the onset of epileptic seizures in intracranial electroencephalogram (IEEG), process which is usually done by expert visual inspection, often with variable results. performed fractal dimension (FD) analysis on IEEG recordings obtained from implanted depth and strip electrodes patients refractory mesial temporal lobe epilepsy (MTLE) during evaluation surgery. Results demonstrate reproducible quantifiable pattern that clearly discriminates ictal...
Mounting evidence from animal models of inflammatory and neuropathic pain suggests that inflammation regulates the resolution by producing specialized pro-resolving mediators (SPMs), such as resolvin D1 (RvD1). However, it remains unclear how SPMs are induced in central nervous system whether these mechanisms can be reconciled with outcomes neuromodulation therapies for pain, spinal cord stimulation. Here, we show a male rat model produced spared nerve injury (SNI), 1 kHz stimulation (1 SCS)...
Abstract Objective Understanding the acute effects of responsive stimulation (AERS) based on intracranial EEG (iEEG) recordings in ambulatory patients with drug-resistant partial epilepsy, and correlating these changes clinical seizure frequency, may help clinicians more efficiently optimize settings. Methods In implanted NeuroPace® RNS® System, iEEG spectral power following active sham periods were quantified compared within individual channels. Additionally, stimulation-induced channels...
This study aims to determine whether there are any statistically significant effects in the intracranial EEG signal due brain electrical stimulation that can be quantified by comparing line length value computed windows positioned before and after stimulated abnormal events versus non-stimulated events. The feature has been previously demonstrated preserve waveform dimensionality changes as ones estimated Katz's fractal dimension is a measure sensitive variations amplitude frequency,...
ABSTRACT Spinal cord stimulation (SCS) reduces chronic pain. Conventional (40-60 Hz) SCS engages spinal inhibitory mechanisms by activating low-threshold mechanoreceptive afferents with axons in the dorsal columns (DCs). But DC typically causes a buzzing sensation (paresthesia) that can be uncomfortable. Kilohertz-frequency (1-10 kHz) produces analgesia without paresthesia and is thought, therefore, not to activate axons, leaving its mechanism unclear. Here we show rats kilohertz-frequency...
A control strategy is proposed for AC thyristor controllers. The main feature of the technique that motors can start with high torque, while using an economical design. This allows use controllers a wide range applications, where they have not been used before. method employs controller as discrete frequency inverter increases until line reached (60 Hz in this case). These frequencies produced by are sub-multiples frequency. They generated omission or inclusion half cycles. Voltage sequences...