A5100730826- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Neurological Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Brain Tumor Detection and Classification
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Respiratory viral infections research
- Influenza Virus Research Studies
- Functional Brain Connectivity Studies
- Animal Virus Infections Studies
- Monoclonal and Polyclonal Antibodies Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Phagocytosis and Immune Regulation
- Pancreatic and Hepatic Oncology Research
- Imbalanced Data Classification Techniques
- Advancements in Transdermal Drug Delivery
- Adversarial Robustness in Machine Learning
- Spine and Intervertebral Disc Pathology
- Immune Response and Inflammation
- Advanced Text Analysis Techniques
- AI in Service Interactions
- Migration and Labor Dynamics
Handong Global University
2025
Korea University
2008-2024
Inje University Sanggye Paik Hospital
2021
Korea Testing Laboratory
2021
Inje University Busan Paik Hospital
2021
Kyung Hee University
2017-2021
Agency for Defense Development
2021
Woosuk University
2020
Jeonbuk National University
2013-2019
Chonbuk National University Hospital
2016
In a clinical setting, an individual subject classification model rather than group analysis would be more informative. Specifically, the subtlety of cortical atrophy in some frontotemporal dementia (FTD) patients and overlapping patterns among three FTD syndromes including behavioral variant (bvFTD), non-fluent/agrammatic primary progressive aphasia (nfvPPA), semantic PPA (svPPA) give rise to need for models at level. this study, we aimed classify each into one diagnostic categories...
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infected >200 million people resulting in >4 deaths. However, temporal landscape of the SARS-CoV-2 translatome and its impact on human genome remain unexplored. Here, we report a high-resolution atlas transcriptome for various time points after infecting cells. Intriguingly, substantial amount translation initiates at novel initiation site (TIS) located leader sequence, termed TIS-L. Since TIS-L...
Data on the clinical and virological characteristics of Delta variant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are limited. This prospective cohort study compared to other variants.Adult patients with mild disease 2019 (COVID-19) who agreed daily saliva sampling at a community isolation facility in South Korea between July August 2021 were enrolled. Scores 28 COVID-19-related symptoms recorded daily. The genomic RNA subgenomic from samples measured by real-time...
As an enveloped virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delivers its viral genome into host cells via fusion of the and cell membranes. Here, we show that ANO6/TMEM16F-mediated surface exposure phosphatidylserine is critical for SARS-CoV-2 entry ANO6-selective inhibitors are effective against infections. Application Spike pseudotyped virus (SARS2-PsV) evokes a cytosolic Ca2+ elevation ANO6-dependent externalization in ACE2/TMPRSS2-positive mammalian cells. A...
Accurate liver segmentation from computed tomography (CT) scans is essential for cancer diagnosis and surgery planning. Convolutional neural network (CNN)-based models have limited performance due to their localized receptive fields. Hybrid incorporating CNNs transformers that can capture long-range dependencies shown promising in with the cost of high model complexity. Therefore, a new architecture named G-UNETR++ proposed improve accuracy moderate Two gradient-based encoders take...
There are limited data comparing the transmission rates and kinetics of viable virus shedding Omicron variant to those Delta variant. We compared these in hospitalized patients infected with variants. prospectively enrolled adult COVID-19 admitted a tertiary care hospital South Korea between September 2021 May 2022. Secondary attack were calculated by epidemiologic investigation, daily saliva samples collected evaluate viral kinetics. Genomic subgenomic SARS-CoV-2 RNA was measured PCR,...
To investigate whether dipeptidyl peptidase-4 inhibitors (DPP-4i) have beneficial effects on amyloid aggregation and longitudinal cognitive outcome in diabetic Alzheimer disease-related impairment (ADCI).We retrospectively reviewed 282 patients with ADCI positive 18F-florbetaben PET images. Patients were classified into 3 groups according to prior diagnosis of diabetes DPP-4i use: being treated (ADCI-DPP-4i+, n = 70) or without (ADCI-DPP-4i-, 71) nondiabetic (n 141). Multiple linear...
Abstract Due to the continuously mutating nature of H3N2 virus, two aspects were considered when preparing microneedle vaccines: (1) rapid preparation and (2) cross-protection against multiple antigenic variants. Previous methods measuring hemagglutinin (HA) content required standard antibody, thus vaccines targeting mutant was delayed as a result lacking antibody. In this study, prepared by high performance liquid chromatography (HPLC) without use an several variants observed. The HA...
Abstract Purpose We developed a machine learning–based classifier for in vivo amyloid positron emission tomography (PET) staging, quantified cortical uptake of the PET tracer by using learning method, and investigated impact these parameters on clinical structural outcomes. Methods A total 337 18 F-florbetaben scans obtained at Samsung Medical Center were assessed. defined feature vector representing change from grey to white matter. Using support (SVM) regression SVM classification, we as...
The continuous emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants has provided insights for updating current coronavirus disease 2019 (COVID-19) vaccines. We examined the neutralizing activity Abs induced by a BA.4/5-containing bivalent mRNA vaccine against Omicron subvariants BN.1 and XBB.1.5. recruited 40 individuals who had received monovalent COVID-19 booster dose after primary series vaccinations will be vaccinated with vaccine. Sera were collected before...
Subcortical vascular dementia (SVaD), one of common causes dementia, has concomitant Alzheimer's disease (AD) pathology in over 30%, termed “mixed dementia”. Identifying mixed from SVaD is important because potential amyloid-targeted therapies may be effective for treatment dementia. The purpose this study was to discriminate pure using magnetic resonance imaging (MRI). We measured brain amyloid deposition the 11C-Pittsburgh compound B positron emission tomography (PiB-PET) 68 patients with...
Joon-Yong Bae, Gee Eun Lee, Heedo Park, Juyoung Cho, Jeonghun Kim, Jungmin Kisoon Jin Il Kim,* and Man-Seong Park,*. Biomolecules & Therapeutics 2021;29:268-72. https://doi.org/10.4062/biomolther.2021.032
Abstract Knowledge of the factors affecting difference in kinetics and longevity neutralizing antibody (nAb) response to SARS-CoV-2 is necessary properly prioritize vaccination. In present study, from March December 2020, 143 patients who recovered COVID-19, 87 underwent study visits scheduled every 3 months. Patient demographics blood samples were collected followed by a plaque reduction neutralization test analyze nAb titers. A linear mixed model was used compare effects sex, age, disease...
Mobile healthcare applications are becoming a growing trend. Also, the prevalence of dementia in modern society is showing steady Among degenerative brain diseases that cause dementia, Alzheimer disease (AD) most common. The purpose this study was to identify AD patients using magnetic resonance imaging mobile environment.We propose an incremental classification for systems. Our method based on learning diagnosis and prediction cortical thickness data hippocampus shape. We constructed...
Zoonotic avian influenza viruses pose severe health threats to humans. Of several viral subtypes reported, the low pathogenic H7N9 virus has since February 2013 caused more than 1,500 cases of human infection with an almost 40% case-fatality rate. Vaccination poultry appears reduce infections. However, emergence highly strains increased concerns about pandemics. To develop efficacious vaccine, we designed vaccine by changing patterns N -linked glycosylation (NLG) on hemagglutinin (HA)...
The COVID-19 pandemic is threatening our quality of life and economic sustainability. rapid spread around the world requires each country or region to establish appropriate anti-proliferation policies in a timely manner. It important, making COVID-19-related health policy decisions, predict number confirmed patients as accurately quickly possible. Predictions are already being made using several traditional models such susceptible, infected, recovered (SIR) exposed, resistant (SEIR)...
Isolation of COVID-19 patients is a crucial infection control measure to prevent further SARS-CoV-2 transmission, but determining an appropriate timing end the isolation challenging. We evaluated performance self-test rapid antigen test (RAT) as potential proxy terminate patients. Symptomatic were enrolled who admitted regional community treatment center (CTC) in Seoul (South Korea). Self-test RAT and collection saliva samples performed by patients, on daily basis, until patient discharge....
Abstract Major challenges for CAR-T cell therapy in solid tumors include various limitations due to the issue of appropriate antigen selection, tumor heterogeneity, and immune-suppressive microenvironment (TME). To overcome these hurdles, we’ve developed a novel therapy, CLM-202 which is combination oncolytic Newcastle disease virus (NDV) NDV F protein-targeted (NDV CAR-T). After infects cells, envelope protein expressed on surface. recognizes kills cells. This approach can be applied...