A5013118725- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Cancer, Hypoxia, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Neuroendocrine Tumor Research Advances
- Glioma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Cerebrovascular and Carotid Artery Diseases
- Esophageal Cancer Research and Treatment
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Neuroblastoma Research and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Parkinson's Disease Mechanisms and Treatments
- Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Sarcoma Diagnosis and Treatment
Samsung Medical Center
2016-2025
Sungkyunkwan University
2016-2025
Korea Institute of Machinery and Materials
2017-2020
Pusan National University Hospital
2016
University of Ulsan
2016
Asan Medical Center
2016
Ulsan College
2016
Samsung (United States)
2007-2016
Biomedical Research Institute
2016
Pohang SeMyeong Christianity Hospital
2016
Abstract Background The prognostic significance of volume‐based metabolic parameters measured by 18 F‐fluorodeoxyglucose positron emission tomography/CT ( F‐FDG PET/CT) is not established. We evaluated the value in patients with squamous cell carcinoma (SCC) tonsil. Methods enrolled a total 69 SCC tonsil who underwent pretreatment PET/CT. maximum standardized uptake (SUV max ), tumor volume (MTV), lesion glycolysis (TLG), and asymmetry indices (of SUV , MTV, TLG). these clinical variables...
Resveratrol is gaining attention for its anticancer effects and also recognized antioxidant properties influence on glucose metabolism. Augmented reactive oxygen species (ROS) high glycolytic flux are common characteristics of malignant cells. We thus evaluated the effect resveratrol cancer cell metabolism investigated role ROS in response. <b>Methods:</b> Cancer cells were measured content <sup>18</sup>F-FDG uptake. Assays performed lactate production; hexokinase activity intracellular ROS;...
Amyloid-β (Aβ), tau, and cerebral small vessel disease (CSVD), which occasionally coexist, are the most common causes of cognitive impairments in older people. However, whether tau is observed patients with subcortical vascular impairment (SVCI), as well its associations Aβ CSVD, not yet established. More importantly, role underlying SVCI unknown.To investigate extent using 18F-AV1451, a new ligand to detect neurofibrillary tangles vivo.This cross-sectional study recruited 64 from June 2015...
The utility of <sup>18</sup>F-FDG PET/CT in patients with nasal-type natural killer (NK)/T-cell lymphoma has not been established. Therefore, we evaluated the role for determining cancer staging by comparing its results to those conventional methods (CSMs) (physical examination, CT intravenous contrast, biopsies from primary sites, and bone marrow examinations) NK/T-cell lymphoma. <b>Methods:</b> In this study, 52 consecutive (34 men, 18 women; mean age, 49.4 y) newly diagnosed were studied....
We compared the prognostic value of volume-based metabolic parameters determined using fluorine 18 (F) fluorodeoxyglucose (FDG) positron emission tomography (PET) (F-FDG PET) (with other in uterine cervical cancer.The subjects were 73 female patients who had an initial diagnosis cancer and underwent F-FDG PET. Various or PET including maximum average standardized uptake values, tumor volume, total lesion glycolysis (TLG) measured primary tumors. Survival analysis for disease-free survival...
There is rising interest in recruitment of brown adipocytes into white adipose tissue (WAT) as a means to augment energy expenditure for weight reduction. We thus investigated the potential <sup>18</sup>F-FDG uptake an imaging biomarker that can monitor process WAT browning. <b>Methods:</b> C57BL/6 mice were treated daily with β3 agonist CL316,243 (5-[(2<i>R</i>)-2-[[(2<i>R</i>)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt), whereas...
We investigated the capacity of F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) to differentially diagnose immunoglobulin G4-related disease (IgG4-RD) in clinically suspected patients.Subjects were 94 patients who had tissue IgG4 staining (n = 85) or serum greater than 135 mg/dL 9) and underwent FDG PET/CT within 40 days. Clinical, serologic, pathological, findings analyzed. Binary logistic regression analysis was performed assess diagnostic...
We aimed to compare amyloid-β (Aβ) accumulation rates between different tracers and investigate whether the relationship changes in Aβ uptake cognitive decline varies depending on tracer type. Two cohorts were analyzed: (1) a head-to-head longitudinal cohort using 18F-Florbetaben (FBB) 18F-Flutemetamol (FMM) (n = 13), (2) separate for each 174 both FMM FBB), matched by propensity score. was measured regional direct comparison of Centiloid (rdcCL) values. In cohort, subtracting rdcCL from FBB...
Vivax malaria reemerged in the Republic of Korea 1993. Most cases occurred among soldiers region adjacent to Demilitarized Zone (DMZ) until 1995. To determine rate dispersion vivax malaria, we evaluated its epidemiologic characteristics. Of 13,903 reported 2000, 40.1% (5,577) were military personnel, 26.2% (3,641) veterans discharged less than two years from military, and 33.7% (4,685) civilians. Cases have rapidly increased annually counties bordering DMZ, spread approximately 40 km south...
Abstract Background The role of 18 F ‐fluorodeoxyglucose positron emission tomography/computed tomography ( ‐ FDG PET / CT ) in evaluating pulmonary artery lesions has not yet been established. purpose this study is to evaluate the usefulness imaging differentiating malignant from benign PA lesions. Methods In retrospective study, subjects with 26 low‐attenuated filling defects suspicious for malignancy on contrast‐enhanced chest were enrolled; all whom subsequently underwent . maximum...
Objective: To evaluate the prognostic value of volume-based metabolic parameters measured with 18 F-fluorodeoxyglucose ( F-FDG) positron emission tomography (PET) in patients clinically node-negative (cN0) oral tongue squamous cell carcinoma (OTSCC) as compared other factors.Materials and Methods: In this study, we included a total 57 who had been diagnosed cN0 cancer by radiologic, F-FDG PET/CT, physical examinations.The maximum standardized uptake (SUV max ), average SUV avg tumor volume...
The Centiloid (CL) is a method for standardizing amyloid beta (Aβ) quantification through different ligands and methods. To find the most appropriate reference region to reduce variance in Aβ CL unit between 18F-florbetaben (FBB) 18F-flutemetamol (FMM), we conducted head-to-head comparisons from 56 participants using direct comparison of FBB-FMM (dcCL) with four regions: cerebellar gray (CG), whole cerebellum (WC), WC brainstem (WC + B), pons. FBB FMM dcCL units were highly correlated (R2 =...
Taking a step forward from the IPI, attention is focused on role of 18F-FDG PET/CT as tool for guidance in risk stratification patients with aggressive non-Hodgkin's lymphoma (NHL). Here, we analyzed predictive value various parameters DLBCL. Particularly, were interested an IPI score 1, 2, or 3, whose prognosis are confusing. Between Jul 2008 and Feb 2010, total 100 (including 57 1-3) who treated R-CHOP DLBCL, had assessable this study. Absolute SUVmax, SUVsum(sum SUVmax) TLGsum(SUVmean x...
We investigated the relation of carotid <sup>18</sup>F-FDG uptake to high-sensitivity C-reactive protein (hsCRP) and Framingham risk score (FRS) in a large cohort asymptomatic adults. <b>Methods:</b> Carotid artery was measured on PET/CT scans 1,181 subjects, maximum target-to-background ratio (M-TBR) intima-media thickness (IMT) were compared with clinical factors hsCRP. The estimated 10-y for general cardiovascular disease calculated by FRS. <b>Results:</b> FRS increased from 11.5% ± 7.8%...
The polarization anomaly refers to the transition from longitudinal shear modes along an equi-frequency contour of same branch, which occurs only in some anisotropic elastic media, but lack natural materials exhibiting desired anisotropy makes its utilization impossible for potential novel applications. In this paper, we present a unique, non-resonant type metamaterial made off-centered, double-slit unit cells. We show that wave characteristics determine anomalous certain application are...
To fully understand the glycolytic behavior of cancer cells, it is important to recognize how linked pH dynamics. Here, we evaluated acute effects mild acidification and alkalization on cell glucose uptake flux investigated role hexokinase (HK). Cancer cells exposed buffers with graded were measured for 18F-fluorodeoxyglucose (FDG) uptake, lactate production HK activity. Subcellular localization protein was assessed by western blots confocal microscopy. The interior T47D breast mildly...
To determine whether amyloid and hypertensive cerebral small vessel disease (hCSVD) changes synergistically affect the progression of lobar microbleeds in patients with subcortical vascular mild cognitive impairment (svMCI).Among 72 svMCI who underwent brain MRI [11C] Pittsburgh compound B (PiB)-PET, 52 (72.2%) completed third year follow-up. These were evaluated by annual neuropsychological testing, MRI, follow-up PiB-PET.Over 3 years, 31 (59.6%) had incident (CMBs) deep regions. Both...
We developed an 89Zr-labeled anti-programmed death ligand 1 (anti-PD-L1) immune PET that can monitor chemotherapy-mediated modulation of tumor PD-L1 expression in living subjects. Methods: Anti-PD-L1 underwent sulfohydryl moiety-specific conjugation with maleimide-deferoxamine followed by 89Zr radiolabeling. CT26 colon cancer cells and PD-L1-overexpressing CT26/PD-L1 binding assays, flow cytometry, Western blotting. In vivo pharmacokinetics, biodistribution, imaging were evaluated mice....