A5102540634- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Diet and metabolism studies
- Health and Wellbeing Research
- Alcoholism and Thiamine Deficiency
- Diverse Approaches in Healthcare and Education Studies
- Frailty in Older Adults
- Artificial Intelligence in Healthcare
- Neurological and metabolic disorders
- Glaucoma and retinal disorders
- Neurological Disorders and Treatments
- Microbial infections and disease research
- Ophthalmology and Eye Disorders
- Nutritional Studies and Diet
- Genomics and Phylogenetic Studies
- Health, Environment, Cognitive Aging
- Healthcare Education and Workforce Issues
- Functional Brain Connectivity Studies
- Cerebral Venous Sinus Thrombosis
- Bacteriophages and microbial interactions
Samsung Medical Center
2024-2025
Sungkyunkwan University
2024-2025
Kyungpook National University
2024
Seoul National University
2023
Dementia, particularly Alzheimer's disease, is a significant global health concern, with early diagnosis and treatment development being critical goals. While numerous cohorts have advanced dementia research, there lack of comprehensive data on ethnic differences, for the Korean population. The Korea-Registries to Overcome Dementia Accelerate Research (K-ROAD) aims establish large-scale, hospital-based cohort address this gap, focus understanding disease progression, developing diagnostics,...
Abstract INTRODUCTION This study aimed to investigate the differential roles of various plasma biomarkers in a stepwise diagnostic strategy for Alzheimer's disease (AD). METHODS A total 2984 participants, including 666 cognitively unimpaired (CU), 2032 with clinical syndrome (ACS), and 286 non‐ACS individuals, were recruited. Plasma amyloid beta (Aβ) 42/40, four phosphorylated tau (p‐tau) epitopes, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL) levels measured using...
Importance Understanding the characteristics of discordance between plasma biomarkers and positron emission tomography (PET) results in Alzheimer disease (AD) is crucial for accurate interpretation findings. Objective To compare (1) medical comorbidities affecting biomarker concentrations, (2) imaging clinical features, (3) cognitive changes PET discordant concordant cases. Design, Setting, Participants This multicenter cohort study, conducted 2016 2023, included individuals with unimpaired...
We aimed to compare amyloid-β (Aβ) accumulation rates between different tracers and investigate whether the relationship changes in Aβ uptake cognitive decline varies depending on tracer type. Two cohorts were analyzed: (1) a head-to-head longitudinal cohort using 18F-Florbetaben (FBB) 18F-Flutemetamol (FMM) (n = 13), (2) separate for each 174 both FMM FBB), matched by propensity score. was measured regional direct comparison of Centiloid (rdcCL) values. In cohort, subtracting rdcCL from FBB...
Physical activity (PA) is a nonpharmacological intervention for dementia prevention. The association between PA and Alzheimer disease (AD) plasma biomarkers remains underexplored. To investigate the associations among PA; biomarkers, including β-amyloid 42/40 (Aβ42/40), phosphorylated-tau217 (ptau217), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL); cognition. This cross-sectional study included participants with without cognitive impairment recruited from multiple...
Background: Amyloid-β (Aβ) commonly coexists and impacts prognosis in subcortical vascular cognitive impairment (SVCI). Objective: This study aimed to examine the differences clinical neuroimaging variables between Aβ-positive Aβ-negative SVCI propose a prediction model for Aβ positivity clinically diagnosed patients. Methods: A total of 130 patients with were included development, separate cohort 70 was used external validation. The selected by comparing characteristics groups. final...
We aimed to investigate which factors affect plasma biomarker levels via amyloid beta (Aβ)-independent or Aβ-dependent effects and improve the predictive performance of these biomarkers for Aβ positivity on positron emission tomography (PET). A total 2935 participants underwent blood sampling measurements Aβ42/40 ratio, phosphorylated tau 217 (p-tau217; ALZpath), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL) using single-molecule array PET. Laboratory findings were...
Incongruous visual field defects, such as sectoranopia, can result from lateral geniculate nucleus infarction. We present a rare case of right infarction that manifests left inferior homonymous paracentral scotoma. According to the retinotopic organization tract, central vision macula is delivered occipital pole via posterior portion nucleus. Consequently, not only lead loss, but partial also produce similar manifestations loss.
Background The clinical effects of β-amyloid positivity (Aβ+) on copathologies in various dementias remain relatively underexamined. Thus, the present study was conducted to investigate prevalence and Aβ+ subcortical vascular cognitive impairment (SVCI) frontotemporal dementia (FTD). Patients Methods We enrolled SVCI (n = 583), FTD 152), cognitively unimpaired (CU) participants 1,249) who underwent Aβ PET scans. odds having were subsequently compared among diagnostic groups (CU, SVCI, FTD)...
Abstract Background Plasma biomarkers for Alzheimer’s disease (AD) have demonstrated their accuracy as diagnostic tools, suggesting impending integration into clinical practice. Medical comorbidities might not only affect AD pathological burdens but also cause variability of plasma by affecting transfer via blood brain barriers. In the present study, we aimed to determine which with (real effects) or without (biological variability) measured β‐amyloid (Aβ) uptakes on PET. Method We recruited...
Abstract Background Ethnic differences in amyloid‐β (Aβ) characteristics and cognitive trajectories should be considered, when designing Aβ‐targeted therapies. The clinical effects of co‐pathologies Aβ have not been evaluated extensively across various dementias. We investigated the prevalence Aβ+ Koreans non‐Hispanic whites (NHWs) with Alzheimer’s syndrome (ACS) other Method included 5,856 who underwent positron emission tomography (PET) South Korea. participants were categorized into...
Abstract INTRODUCTION We investigated the prevalence of amyloid beta (Aβ) positivity (+) and cognitive trajectories in Koreans non‐Hispanic Whites (NHWs). METHODS included 5121 from multiple centers across South Korea 929 NHWs Alzheimer's Disease Neuroimaging Initiative (ADNI). Participants underwent Aβ positron emission tomography were categorized into cognitively unimpaired (CU), mild impairment (MCI), dementia stages. Age, sex, education, apolipoprotein E . genotype adjusted using...
<title>Abstract</title> We aimed to compare amyloid-β (Aβ) accumulation rates between different tracers and investigate whether the relationship changes in Aβ uptake cognitive decline varies depending on tracer type. Two cohorts were analyzed: (1) a head-to-head longitudinal cohort using [18F]florbetaben (FBB) [18F]flutemetamol (FMM) (n = 13), (2) separate for each 174 both FMM FBB), matched by propensity score. was measured regional direct comparison of Centiloid (rdcCL) values. In cohort,...
This study aimed to investigate the characteristics of individuals with amyloid levels below threshold. To achieve this, we differentiated between two groups: those global negativity but focal deposition [G(-)F(+)] and without [G(-)F(-)].
Purpose: The purpose of this study was to investigate the comparison self-resilience, self-efficacy, and vocation Korea Armed Forces Nursing academy (KAFNA) cadets civilian nursing college students. Methods: This a descriptive comparative study. 121 KAFNA 117 students participated in Data were collected from July 1 22 using structured questionnaires. data analyzed statistics, t-test, ANOVA, Pearson correlation coefficients. questionnaire consisted 32 questions 23 self-efficacy 24 vocation....