A5033481071- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Bacillus and Francisella bacterial research
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Respiratory viral infections research
- COVID-19 epidemiological studies
- Antifungal resistance and susceptibility
- Health and Wellbeing Research
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Long-Term Effects of COVID-19
- Heparin-Induced Thrombocytopenia and Thrombosis
- Bacteriophages and microbial interactions
- Ocular Diseases and Behçet’s Syndrome
- Hepatitis B Virus Studies
- Ocular Infections and Treatments
- Fungal Infections and Studies
- Ultrasound in Clinical Applications
- COVID-19 diagnosis using AI
- Immune responses and vaccinations
Asan Medical Center
2017-2025
Ulsan College
2015-2025
University of Ulsan
2015-2025
National Medical Center
2023-2024
Incheon St. Mary's Hospital
2020-2022
Catholic University of Korea
2022
BACKGROUND: We performed a prospective survey on the adverse reactions following first dose of two types vaccines against coronavirus disease 2019 (COVID-19) in healthcare workers (HCWs) South Korea. METHODS: HCWs at tertiary referral hospital Seoul, Korea, received chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19) or an mRNA-based (BNT162b2) between March 5 and 26, 2021. The were asked to report through mobile self-report questionnaire for three days after vaccination. RESULTS: A...
<h3>Importance</h3> Data are limited on whether patients with breakthrough COVID-19 infection have the potential to significantly contribute spread of SARS-CoV-2. <h3>Objective</h3> To compare secondary attack rate and infectious viral shedding kinetics SARS-CoV-2 between fully vaccinated individuals (breakthrough group) partially or unvaccinated (nonbreakthrough group). <h3>Design, Setting, Participants</h3> This cohort study assessed transmission by analyzing epidemiologic data health care...
We conducted a prospective, mobile-based survey on the self-reported adverse reactions in healthcare workers (HCWs) who received both doses of BNT162b2 mRNA vaccine. Of 342 HCWs completed two-dose vaccination, 265 (77.5%) responded to at least once. Overall, rates were higher after second dose compared with first (89.1% vs. 80.1%, P = 0.006). The most common systemic muscle ache (69.1%), fatigue (65.7%), headache (48.7%), chills (44.2%), and fever (32.1%), notably more vaccine as well. also...
Data on the clinical and virological characteristics of Delta variant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are limited. This prospective cohort study compared to other variants.Adult patients with mild disease 2019 (COVID-19) who agreed daily saliva sampling at a community isolation facility in South Korea between July August 2021 were enrolled. Scores 28 COVID-19-related symptoms recorded daily. The genomic RNA subgenomic from samples measured by real-time...
There are limited data on the rates of waning antibody levels after two-dose and booster vaccination according to different platforms COVID-19 vaccines.We enrolled healthcare workers (HCWs) in a tertiary care hospital who received homologous vaccination, followed by or heterologous mRNA vaccine. SARS-CoV-2 S1-specific IgG was measured using ELISA. A linear mixed regression model used compare slope from peak titre lowest titres 3 months vaccination.A total 113 HCWs (BNT162b2 (n = 48 [42%]),...
In response to the Mpox domestic epidemic, South Korea initiated a nationwide vaccination program in May 2023, administering 0.1 mL intradermal dose of JYNNEOS (Modified Vaccinia Ankara vaccine, Bavarian Nordic) high-risk group. To investigate adverse reactions after vaccination, an anonymous online survey was conducted at National Medical Center from 22 July 31, 2023. Overall, 142 individuals responded. Over 80% respondents reported local predominantly mild severity. The predominant were...
We conducted a prospective cohort study at community facility designated for the isolation of individuals with asymptomatic or mild COVID-19 between 10 January and 22 February 2021 to investigate relationship viral shedding symptom changes COVID-19. In total, 89 adult patients (12 asymptomatic, 16 presymptomatic, 61 symptomatic) were enrolled. Symptom scores, genomic RNA subgenomic SARS-CoV-2 from saliva samples cell culture measured. Asymptomatic had similar load symptomatic during early...
There are limited data directly comparing immune responses to vaccines and natural infections with coronavirus disease 2019 (COVID-19). This study assessed the immunogenicity of BNT162b2 ChAdOx1 nCoV-19 over a 3-month period compared those infections.We enrolled healthcare workers who received or patients confirmed COVID-19 then measured S1 immunoglobulin (Ig) G neutralizing antibodies T-cell responses.A total 121 vaccinees 26 were analyzed. After second dose, vaccine yielded IgG antibody...
There are limited data comparing the transmission rates and kinetics of viable virus shedding Omicron variant to those Delta variant. We compared these in hospitalized patients infected with variants. prospectively enrolled adult COVID-19 admitted a tertiary care hospital South Korea between September 2021 May 2022. Secondary attack were calculated by epidemiologic investigation, daily saliva samples collected evaluate viral kinetics. Genomic subgenomic SARS-CoV-2 RNA was measured PCR,...
Quality-adjusted life expectancy (QALE) means (LE) reflecting health-related quality of and is one the indicators healthy LE. We determined trends in QALE Korea by age, gender, educational level, subregion from 2005 to 2013. applied Sullivan method estimate QALE. calculated 2013 gender for 2010 level at national level. Furthermore, we estimated 2005, 2008, 2011 according metropolitan provincial levels. Population health measured LE age 0 increased steadily Annual percent changes men were...
Abstract There are limited data supporting current Centers for Disease Control and Prevention guidelines the isolation period in moderate to severely immunocompromised patients with coronavirus disease 2019 (COVID‐19). Adult COVID‐19 who underwent solid organ transplantation (SOT) or received active chemotherapy against hematologic malignancy were enrolled weekly respiratory samples collected. Samples positive genomic real‐time polymerase chain reaction results virus culture rapid antigen...
There are limited data directly comparing humoral and T cell responses to the ChAdOx1 nCoV-19 BNT162b2 vaccines. We compared Ab after first doses of vs. enrolled healthcare workers who received or vaccine in Seoul, Korea. Anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S1 protein-specific IgG Abs (S1-IgG), neutralizing (NT Abs), SARS-CoV-2-specific response were evaluated before vaccination at 1-wk intervals for 3 wks vaccination. A total 76 persons, comprising 40 injected...
Abstract Following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, subsequent ChAdOx1 nCoV-19 vaccination induced similar neutralizing antibody levels against the original strain but significantly higher Omicron variant compared to those who were not vaccinated. Prior SARS-CoV-2 infection exhibited neutralization titers than alone for both strains and variant.
The global burden of liver diseases, such as hepatocellular carcinoma and cirrhosis, is substantial. In this study, we estimated utility weights disease-related health states in the general population using a visual analogue scale (VAS) standard gamble (SG) method. Depictions standardized related to major diseases were developed based on patient education materials previous publications. To fully reflect disease progression from diagnosis prognosis, each state comprised four parts:...
Correlation between vaccine reactogenicity and immunogenicity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. Thus, we investigated to determine whether the after disease 2019 vaccination associated with antibody (Ab) titers T cell responses. This study was prospective cohort done 131 healthcare workers at tertiary center in Seoul, South Korea. The degrees of local reactions 1st 2nd doses ChAdOx1 nCov-19 (ChAdOx1) were significantly S1-specific IgG Ab...