A5100328564- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Poxvirus research and outbreaks
- Diverse Approaches in Healthcare and Education Studies
- Herpesvirus Infections and Treatments
- Bacillus and Francisella bacterial research
- SARS-CoV-2 detection and testing
- Nutrition, Health and Food Behavior
- Drug-Induced Adverse Reactions
- Influenza Virus Research Studies
- Health and Wellbeing Research
- Criminal Law and Evidence
- Skin Protection and Aging
- melanin and skin pigmentation
- Vaccine Coverage and Hesitancy
- Liver Disease Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Education and Learning Interventions
- Student Assessment and Feedback
- Healthcare and Venom Research
- Viral gastroenteritis research and epidemiology
- Energy and Environmental Systems
- Air Quality and Health Impacts
National Medical Center
2021-2024
Yonsei University
2010-2023
Chemnitz University of Technology
2022
Dongguk University
2021
Korea Disease Control and Prevention Agency
2017-2020
Korea Center for Disease Control and Prevention
2016-2020
Ewha Womans University Medical Center
2013
Seoul National University Bundang Hospital
2013
Chungnam National University
2007
Inje University
2004
Since severe acute respiratory syndrome-coronavirus-2 variant B.1.1.529 (omicron) was first reported to the World Health Organization on November 24, 2021, cases of omicron have been detected in more than 90 countries over last month. We investigated clinical and epidemiological characteristics 40 patients with who had isolated at National Medical Center South Korea during December 4-17, 2021. The median age 39.5 years. Twenty-two (55%) were women. Seventeen (42.5%) fully vaccinated, none...
Toxoplasma gondii infection induces alteration of the host cell cycle and proliferation. These changes are not only seen in directly invaded cells but also neighboring cells. We tried to identify whether this can be mediated by exosomes secreted T. gondii-infected L6 cells, a rat myoblast line, RH strain were selected for study. infected with or without isolate exosomes. The cellular growth patterns identified counting trypan blue under confocal microscopy, investigated flow cytometry....
In response to the Mpox domestic epidemic, South Korea initiated a nationwide vaccination program in May 2023, administering 0.1 mL intradermal dose of JYNNEOS (Modified Vaccinia Ankara vaccine, Bavarian Nordic) high-risk group. To investigate adverse reactions after vaccination, an anonymous online survey was conducted at National Medical Center from 22 July 31, 2023. Overall, 142 individuals responded. Over 80% respondents reported local predominantly mild severity. The predominant were...
Infection with Clostridium difficile is a growing concern because of the increasing prevalence and spread nosocomial infections. Emergence hypervirulent 027/NAP1/BI strain also notable. Existing diagnostic methods have low sensitivity or are time-consuming. Therefore, establishing rapid accurate microbiological assay needed. We evaluated Xpert C. (Xpert CD assay; Cepheid, USA) to detect toxigenic difficile. This real-time multiplex PCR that can be used strains differentiate presumptive...
The study is investigated socioeconomic variations in self-rated health status and contribution of behavioral factors Korea.A nationally representative sample (2,800 men 3,230 women aged 20-64 years) from the 2005 Korea National Health Nutrition Surveys was analyzed using logistic regression.Self-rated lower among groups compared with higher groups, gender being irrelevant. This association attenuated when socio-demographic were adjusted. When each factor considered separately, mediators...
Older adults are given high priority for coronavirus disease 2019 (COVID-19) vaccination; however, little is known about the safety of vaccines. This study was conducted to examine COVID-19 vaccine people who were ≥ 75 years age, specifically those first took two doses at central vaccination center in South Korea.Safety monitoring after BNT162b2 three ways older received dose our between April 5 and 23, 2021. For immediate adverse reactions, every person vaccinated observed 15-30 minutes...
The frequency and clinical manifestation of lung fibrosis accompanied by coronavirus disease (COVID-19) are not well-established. We aimed to identify the factors attributed post-COVID-19 fibrosis. This single-center prospective study included patients diagnosed with COVID-19 pneumonia from 12 April 22 October 2021 in Republic Korea. primary outcome was presence pulmonary on a CT scan 3 months after discharge; risk estimated multiple logistic regression. mean patient age 55.03 ± 12.32 (range...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant (B.1.1.529) is dominating disease 2019 (COVID-19) worldwide. waning protective effect of available vaccines against the a critical public health issue. This study aimed to assess impact third COVID-19 vaccination on immunity SARS-CoV-2 BA.1 strain in older individuals.
Background This study evaluated the clinical characteristics of patients with COVID-19 in Korea, and examined relationship between severe cases underlying health conditions during Delta (September 20, 2021 to December 4, 2021) Omicron (February 2022 March 31, 2022) predominant period. Methods assessed association critical illness various risk factors, including a variety conditions, using multiple logistic regression models based on K-COV-N cohort, nationwide data confirmed linked...
Concerns about the effectiveness of current vaccines against rapidly spreading severe acute respiratory syndrome-coronavirus-2 omicron (B.1.1.529) variant are increasing. This study aimed to assess neutralizing antibody activity wild-type (BetaCoV/Korea/KCDC03/2020), delta, and variants after full primary booster vaccinations with BNT162b2. A plaque reduction neutralization test was employed determine 50% dilution (ND
Information on the effectiveness of nirmatrelvir/ritonavir against omicron is limited. The clinical response and viral kinetics to therapy in real world need be evaluated.Mild moderate coronavirus disease 2019 (COVID-19) patients with risk factors for severe illness were prospectively enrolled as a treatment group versus control supportive care. Serial load culture from upper respiratory tract evaluated seven days, responses adverse reactions 28 days.A total 51 analyzed including 40 11...
A 35-year-old man who returned from Germany developed fever, generalized pain, severe anal and skin rash, confirmed to be monkeypox (mpox). While he was previously human immunodeficiency virus infected, antiretroviral therapy ensured his immunocompetence. The mpox-related prodromal symptoms disappeared before isolation, subsequent several vesicular lesions healed after admission. moderate pain persisted for a few days, it improved during hospitalization. mpox no longer detected in samples...
Purpose:In recent years, research on reported adverse events following immunization (AEFI) and claims filed for compensation has been lacking.We reviewed AEFIs in Korea from 2011 to 2016. Materials Methods:We listed all of the AEFI registered Integrated Management System Disease Public Health list serious 2016.Results: An average 278 cases was annually 2016.Of these, 31 deaths were reported.However, there no association found between these vaccinations when evaluating vaccine lot, reviewing...
Abstract Backgrounds Remdesivir (RDV) is an antiviral agent approved for the treatment of coronavirus disease 2019 (COVID-19); however, not recommended patients with renal impairment. Due to limitations associated prospective clinical trials, real-world data on safety and efficacy RDV in impairment are necessary. Methods Propensity score-matched (PSM) retrospective analysis was conducted between March 2020 September 2022 COVID-19 eGFR < 30 mL/min four Korean hospitals. The group matched...
Coronavirus disease 2019 (COVID-19) is a newly emerged infectious that needs further clinical investigation. Characterizing the temporal pattern of combined infections in patients with COVID-19 may help clinicians understand nature this and provide valuable diagnostic therapeutic guidelines. We retrospectively analyzed isolated four study hospitals Korea for one year period from May 2021 to April 2022 when delta omicron variants were dominant. The characteristics based on specific tests...
The use of egg microneedles (EMN) is a promising transdermal vaccine delivery technique, effectively preserving the vaccine's activity during its dissolution and directly into skin upon administration.
Nirmatrelvir-ritonavir is highly effective in preventing severe coronavirus disease 2019 (COVID-19) high-risk patients with mild-to-moderate severity. However, real-world performance data are limited, and the drug not so acceptable to COVID-19 at high risk who need it Korea.To evaluate effectiveness of nirmatrelvir-ritonavir, we conducted a propensity score-matched retrospective cohort study on for were hospitalized four hospitals South Korea from February 2022 April 2022. A total 236...
Objectives : The purpose of the this study was to obtain necessary source data for development oral health improvement and promotion programs elderly by investigating actual situations education related experience needs that senior citizens had in Korea. Methods In study, convenience sampling conducted 430 aged 65 years who lived Seoul Gyeonggi-do Korea, about six months from December 2011 May 2012. For collection, structured questionnaire used. Community-based citizens' welfare facilities...
A national immunization program (NIP) to prevent disease and reduce mortality from vaccine preventable diseases (VPD) is very important.We analyzed only the anaphylaxis cases that occurred between 2001 2016 Korea Centers for Disease Control Prevention (KCDC) determined had a definite causal relationship with vaccine. The clinical symptoms were assessed according Brighton Collaboration case definition (BCCD) level.During period, there 13 of vaccine-related anaphylaxis. median age was 9 years...
Wearing a mask is still advised since COVID-19 continues to spread. However, masks may also irritate the skin and cause acne, often known as “maskne”, which type of acne mechanica caused by friction between clothing. Therefore, there need develop an effective maskne cosmetic. In this study, we made cosmetics containing Humulus lupulus extract Copper tripeptide-1 investigated its stability, safety anti-inflammatory efficacy. The results indicated that samples were stable after centrifugation,...
We aimed to characterize the genomes of monkeypox virus isolates from Far East, providing insights into viral transmission and evolution. Genomic analysis was conducted on 8 obtained patients with disease in Republic Korea between May 2022 early 2023. These were classified Clade IIb. Distinct lineages, including B.1.1, A.2.1, B.1.3, observed 2023 isolates, only B.1.3 lineage detected six genetic features specific East (the Korea, Japan, Taiwan), distinguishing them diverse lineages found...