A5021823162- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Influenza Virus Research Studies
- Bacteriophages and microbial interactions
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Plant Virus Research Studies
- RNA Interference and Gene Delivery
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Immune Response and Inflammation
- Probiotics and Fermented Foods
- Peripheral Neuropathies and Disorders
- RNA regulation and disease
- Hepatitis B Virus Studies
- Myasthenia Gravis and Thymoma
- Immune Cell Function and Interaction
- Antimicrobial Peptides and Activities
- Botulinum Toxin and Related Neurological Disorders
- Cancer Mechanisms and Therapy
- Animal Virus Infections Studies
- Nanopore and Nanochannel Transport Studies
- Travel-related health issues
Korea Disease Control and Prevention Agency
2009-2025
Korea Center for Disease Control and Prevention
2009-2018
Korea National Institute of Health
2010-2018
Centers for Disease Control and Prevention
2010-2013
National Cancer Center
2012
Gwangju Institute of Science and Technology
2008
Abstract Following the worldwide surge in mpox (monkeypox) 2022, cases have persisted Asia, including South Korea, and sexual contact is presumed as predominant mode of transmission, with a discernible prevalence among immunocompromised patients. Drugs such tecovirimat can result drug‐resistant mutations, presenting obstacles to treatment. This study aimed ascertain presence tecovirimat‐related resistant mutations through genomic analysis monkeypox virus isolated from reported case involving...
Botulinum neurotoxins (BoNTs), produced by Clostridium botulinum, are potent protein toxins that can cause botulism, which leads to death or neuroparalysis in humans targeting the nervous system. BoNTs comprise three functional domains: a light-chain enzymatic domain (LC), heavy-chain translocation (HCN), and receptor-binding (HCC). The HCC is critical for binding neuronal cell membrane receptors facilitating BoNT internalization via endocytosis. Accordingly, it may serve as vaccine...
Monkeypox outbreaks in nonendemic countries have been reported since early May 2022. The first case of monkeypox the Republic Korea was confirmed a patient who traveled to Europe June 2022, and an attempt made isolate identify virus (MPXV) from patient's specimens.Clinical specimens were inoculated Vero E6 cells. isolated identified as MPXV by observation cytopathic effects on cells, transmission electron microscopy, conventional polymerase chain reaction (PCR), sequencing PCR...
Alternative splicing of mRNA enables functionally diverse protein isoforms to be expressed from a single gene, allowing transcriptome diversification. Interleukin (IL)-24/MDA-7 is member the IL-10 gene family, and FISP (IL-4-induced secreted protein), its murine homologue, selectively by T helper 2 lymphocytes. A novel splice variant mouse IL-24/FISP, designated FISP-sp, lacks 29 nucleotides 5'-end exon 4 FISP. The level FISP-sp expression 10% total primary transcription. Unlike FISP, does...
Abstract To identify oseltamivir resistance, we analyzed neuraminidase H275Y mutations in samples from 10 patients infected with pandemic (H1N1) 2009 virus South Korea who had influenza that was refractory to antiviral treatment this drug. A I117M mutation might influence susceptibility detected sequential specimens 1 patient.
Background: Despite its global eradication in 1977, smallpox remains a concern owing to potential as biological agent, thereby prompting the ongoing development and utilization of vaccine. Vaccination with Vaccinia virus induces immunity against variola virus, causative agent smallpox; however, this does not extend viruses different genera within Poxviridae family. In study, we aimed assess efficacy an enzyme-linked immunosorbent assay (ELISA) method utilizing recombinant A27L antigen for...
: Despite its global eradication in 1977, smallpox remains a concern owing to potential as biological agent, thereby prompting the ongoing development and utilization of vaccine. Vaccination with
Abstract During the influenza pandemic of 2009–2010, rapid diagnostic tests (RIDTs) were used to detect viral infections because they are quick and simple use. However, retrospective studies showed that RIDTs performed poorly when diagnose infections. Determining how amino acid sequence changes in or epidemic antigens impact clinical value has not been possible, epitopes recognized by have mapped. In this study, effect escape‐variations mutations upon sensitivity specificity an RIDT was...
We report the complete genome sequence of monkeypox virus strain MPXV-ROK-P1-2022, isolated from first patient diagnosed with in Republic Korea June 2022. The was fully sequenced on Illumina MiSeq instrument, and phylogenetic tree showed that belongs to lineage B.1.1.
We describe a patient with multiple myeloma who developed pandemic influenza A (H1N1) 2009 virus infection during chemotherapy. The clinical condition of the worsened and viral shedding persisted despite 10 days peramivir treatment; however ceased recovered completely inhaled zanamivir.
We aimed to characterize the genomes of monkeypox virus isolates from Far East, providing insights into viral transmission and evolution. Genomic analysis was conducted on 8 obtained patients with disease in Republic Korea between May 2022 early 2023. These were classified Clade IIb. Distinct lineages, including B.1.1, A.2.1, B.1.3, observed 2023 isolates, only B.1.3 lineage detected six genetic features specific East (the Korea, Japan, Taiwan), distinguishing them diverse lineages found...
Following the worldwide surge in mpox(monkeypox) 2022, cases have persisted Asia, including South Korea, and sexual contact is presumed as predominant mode of transmission, with a discernible prevalence among immunocompromised patients. Drugs such tecovirimat can result drug-resistant mutations, presenting obstacles to treatment. This study aimed ascertain presence tecovirimat-related resistant mutations through genomic analysis monkeypox virus isolated from reported case involving prolonged...
Intracellular transduction of hydrophilic macromolecules has been problematic owing to the biochemical restriction imposed by lipid bilayer cytoplasmic membrane. Several technologies have developed improve intracellular delivery large molecules for therapeutic purpose, including cell penetrating peptide. Cell peptides or permeable (CPPs) were initially discovered based on potency certain full-length proteins translocate across plasma Currently, CPPs are broadly applied biologically...