A5086590761- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Hepatitis B Virus Studies
- Hereditary Neurological Disorders
- Bacillus and Francisella bacterial research
- Yersinia bacterium, plague, ectoparasites research
- Streptococcal Infections and Treatments
Korea Disease Control and Prevention Agency
2021-2025
Botulinum neurotoxins (BoNTs), produced by Clostridium botulinum, are potent protein toxins that can cause botulism, which leads to death or neuroparalysis in humans targeting the nervous system. BoNTs comprise three functional domains: a light-chain enzymatic domain (LC), heavy-chain translocation (HCN), and receptor-binding (HCC). The HCC is critical for binding neuronal cell membrane receptors facilitating BoNT internalization via endocytosis. Accordingly, it may serve as vaccine...
Jun Ho Jeon, Ph.D., Chi-Hwan Choi, Jeong Hyun Kim, M.D., Junghee Hyun, M.S., Eun-Sun Sang-Yoon Yong-Woo Shin, Seong Wook Pyo, Dae-Won Byung Hak Kang, Young Joon Park, and Gi-eun Rhie, Ph.D.. Ann Lab Med 2021;41:489-92. https://doi.org/10.3343/alm.2021.41.5.489