A5047101174- Immune Cell Function and Interaction
- Immune cells in cancer
- Neuroscience and Neuropharmacology Research
- Autophagy in Disease and Therapy
- Soybean genetics and cultivation
- Immunotherapy and Immune Responses
- Plant Pathogens and Fungal Diseases
- interferon and immune responses
- Dendrimers and Hyperbranched Polymers
- Plant-Microbe Interactions and Immunity
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Genetics and Neurodevelopmental Disorders
- Whipple's Disease and Interleukins
- Nanoplatforms for cancer theranostics
- Chemokine receptors and signaling
- IL-33, ST2, and ILC Pathways
- Leaf Properties and Growth Measurement
- Antioxidant Activity and Oxidative Stress
- Lung Cancer Treatments and Mutations
- Antifungal resistance and susceptibility
- Plant pathogens and resistance mechanisms
- Fibroblast Growth Factor Research
- Ginseng Biological Effects and Applications
- Cancer Research and Treatments
National Institute of Neurological Disorders and Stroke
2023-2025
National Institutes of Health
2023-2025
Kangwon National University
2013-2024
North Dakota State University
2023
University of Seoul
2020-2021
Government of the Republic of Korea
2019
Agency for Science, Technology and Research
2019
Korea Center for Disease Control and Prevention
2010
Korea Disease Control and Prevention Agency
2010
MRC Cancer Unit
2007
Ginsenosides are the major components responsible for biochemical and pharmacological actions of ginseng, have been shown to various biological activities. In this study, we investigated antiviral activities seven ginsenosides [protopanaxatriol (PT) type: Re, Rf, Rg2; protopanaxadiol (PD) Rb1, Rb2, Rc, Rd)] against coxsackievirus B3 (CVB3), enterovirus 71 (EV71), human rhinovirus 3 (HRV3). Assays activity cytotoxicity were evaluated by sulforhodamine B method using cytopathic effect (CPE)...
Enterovirus 71 (EV71) is the predominant cause of hand, foot and mouth disease (HFMD). The antiviral activity hederasaponin B from Hedera helix against EV71 subgenotypes C3 C4a was evaluated in vero cells. In current study, determined by cytopathic effect (CPE) reduction method western blot assay. Our results demonstrated that 30% ethanol extract containing showed significant reducing formation a visible CPE. Hederasaponin also inhibited viral VP2 protein expression, suggesting inhibition...
4-Phenylbutyric acid (PBA)-installed hyaluronic (HA)-based nanoparticles (NPs) were developed for amplifying the anticancer potential of curcumin (CUR) lung cancer therapy.
Neuroligins (NLGNs) are a family of postsynaptic adhesion molecules that bind to their presynaptic partners, neurexins (NRXNs), facilitating the formation and maintenance synapses. In humans, there five genes encoding NLGNs ( NLGN1-3, NLGN4X , NLGN4Y ), with NLGN1-3 having highly conserved counterparts in rodents, allowing these be studied high confidence translational validity mouse models. Human 4Y were often assumed serve similar functions because they share 97% sequence homology, whereas...
Myd88 is an important adaptor molecule for the activation of NADPH oxidase and arginase-1, which are responsible suppressive function myeloid-derived suppressor cells (MDSCs). When wild-type Myd88(-/-) mice were subcutaneously injected with CT26 colon cancer expressing human Her-2/neu, tumor growth was retarded in than mice. Although generation CD11b(+) Gr-1(+) MDSCs less mice, having masses still had significant quantities MDSCs, suggesting that MDSC might be independent signaling. However,...
Abstract Coxsackievirus B3 (CVB3) is an important human pathogen associated with the development of acute pancreatitis, myocarditis, and type 1 diabetes. Currently, no vaccines or antiviral therapeutics are approved for prevention treatment CVB3 infection. We found that Saururus chinensis Baill extract showed critical activity against infection in vitro . Further, manassantin B inhibited replication suppressed VP1 protein expression Additionally, oral administration mice attenuated...
Endoplasmic reticulum stress is closely associated with the onset and progression of inflammatory bowel disease. ERdj5 an endoplasmic reticulum-resident protein disulfide reductase that mediates cleavage degradation misfolded proteins. Although expression significantly higher in colonic tissues patients disease than healthy controls, its role has not yet been reported. In current study, we used ERdj5-knockout mice to investigate potential roles deficiency causes severe inflammation mouse...
Influenza virus is the major cause of seasonal and pandemic flu. Currently, oseltamivir, a potent selective inhibitor neuraminidase influenza A B viruses, drug choice for treating patients with infection. However, recent emergence oseltamivir-resistant viruses has limited its efficacy. Morin hydrate (3,5,7,2',4'-pentahydroxyflavone) flavonoid isolated from Morus alba L. It antioxidant, anti-inflammatory, neuroprotective, anticancer effects partly by inhibition NF-кB signaling pathway. on...
Trans-Scirpusin A (TSA) is a resveratrol oligomer found in Borassus flabellifer L. We that TSA inhibited the growth of colorectal cancer Her2/CT26 cells vivo mice. Although some cytotoxic T lymphocytes (CTLs) were induced against tumor-associated antigen Her2, treatment did not significantly increase level Her2-specific CTL response compared to with vehicle treatment. However, there was significant TNF-α mRNA tumor tissue and Ab (antibody) production. More importantly, we overcomes...
α-Mangostin is a xanthon derivative contained in the fruit hull of mangosteen (Garcinia mangostana L.), and administration inhibited growth transplanted colon cancer, Her/CT26 cells which expressed Her-2/neu as tumor antigen. Although was reported to have inhibitory activity against sarco/endoplasmic reticulum Ca(2+) ATPase like thapsigargin, it showed different for autophagy regulation. In current study, we found that induced activation mouse intestinal epithelial cells, GFP-LC3 transgenic...
Neuroligins (NLGNs) are postsynaptic cell adhesion molecules that involved in synapse assembly and function. The NLGN gene family consists of 5 genes ( NLGN1-3 , 4X 4Y ). NLGN3 forms heterodimers with other NLGNs is expressed at both excitatory inhibitory synapses, although the distinct role different synapses not fully understood. Cyclin-dependent kinase (Cdk5) a proline-directed serine/threonine targets various neuronal substrates to impact migration, neurite outgrowth, synaptic...
This study investigated the therapeutic potential of Lactobacillus plantarum NCHBL-004 (NCHBL-004) in treatment obesity and associated metabolic disorders.
Codonopsis lanceolata (C. lanceolata) is a traditional medicinal plant used for the treatment of certain inflammatory diseases such as asthma, tonsillitis, and pharyngitis. We evaluated whether steamed fermented C. (SFC) extract improves amyloid-β- (Aβ-) induced learning memory impairment in mice. The Morris water maze passive avoidance tests were to evaluate effect SFC extract. Moreover, we investigated acetylcholinesterase (AChE) activity brain-derived neurotrophic factor (BDNF), cyclic...
IL-22, a pleiotropic cytokine, is known to have profound effect on the regeneration of damaged intestinal barriers. The tissue-protective properties IL-22 are expected be potentially exploited in attenuation and treatment colitis. However, because disease-promoting role chronic inflammation, comprehensive evaluation required translate into clinical domain. Here, we present effective production soluble human bacteria prove whether recombinant has ability ameliorate colitis inflammation. was...
Xanthomonas translucens contains a group of bacterial pathogens that are closely related and have been divided into several pathovars based on their host range. X. pv. undulosa (Xtu) (Xtt) two important cause leaf streak disease wheat barley, respectively. In this study, DNA markers were developed to differentiate Xtu Xtt then used characterize collection strains with diverse origins, followed by confirmation characterization pathogenicity tests multilocus sequence analysis/typing...
N -methyl- D -aspartate receptors (NMDARs) are crucial for neuronal development and synaptic plasticity. Dysfunction of NMDARs is associated with multiple neurodevelopmental disorders, including epilepsy, autism spectrum disorder, intellectual disability. Understanding the impact genetic variants NMDAR subunits can shed light on mechanisms disease. Here, we characterized functional implications a de novo mutation GluN2A subunit (P1199Rfs*32) resulting in truncation C-terminal domain. The...
We describe a patient with multiple myeloma who developed pandemic influenza A (H1N1) 2009 virus infection during chemotherapy. The clinical condition of the worsened and viral shedding persisted despite 10 days peramivir treatment; however ceased recovered completely inhaled zanamivir.
Abstract Background Roses are flowers which contain various phytochemicals and have been used for food medicinal purposes in many countries. Materials, including flowers, available limited periods when plants can be cultivated. Objective To evaluate the quality of rose petals on basis cultivars drying methods, chromaticity, phytochemical contents, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. Method Petals three were dried by hot air (HD) freeze (FD). Subsequently,...