A5004688756- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Virology and Viral Diseases
- Influenza Virus Research Studies
- Reproductive Health and Contraception
- Statistical Methods in Clinical Trials
- Pregnancy and Medication Impact
- Dementia and Cognitive Impairment Research
- Medication Adherence and Compliance
- SARS-CoV-2 detection and testing
- Alzheimer's disease research and treatments
- Pharmacovigilance and Adverse Drug Reactions
- Virus-based gene therapy research
- Data-Driven Disease Surveillance
- Bioinformatics and Genomic Networks
- Extracellular vesicles in disease
- Optimal Experimental Design Methods
- Ectopic Pregnancy Diagnosis and Management
Seoul National University
2025
Korea National Institute of Health
2002-2024
Korea Disease Control and Prevention Agency
2022-2023
Kaiser Permanente
2020
Center for Drug Evaluation and Research
2017-2019
United States Food and Drug Administration
2019
Centers for Disease Control and Prevention
2013
Korea University
2004
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry is mediated by the interaction of viral spike (S) protein with angiotensin-converting enzyme (ACE2) on host cell surface. Although a clinical trial testing soluble ACE2 (sACE2) for COVID-19 currently ongoing, our understanding delivery sACE2 via small extracellular vesicles (sEVs) still rudimentary. With excellent biocompatibility allowing effective molecular cargos, sEVs are broadly studied as nanoscale carriers. In order to...
Abstract INTRODUCTION The molecular mechanisms underlying early‐onset Alzheimer's disease (EOAD) and late‐onset (LOAD) remain incompletely understood, particularly in Asian populations. METHODS RNA‐sequencing was carried out on blood samples from 248 participants the Seoul National University Bundang Hospital cohort to perform differential gene expression (DGE) weighted co‐expression network analysis. Findings were replicated an independent Korean ( N = 275). RESULTS DGE analysis identified...
The prevalence of eight respiratory viruses detected in patients with acute infections (ARIs) Korea was investigated through analysis data recorded by the Influenza and Respiratory Viruses Surveillance System (KINRESS) from 2013 to 2015. Nasal aspirate throat swabs specimens were collected 36 915 ARIs, viral nucleic acids real‐time (reverse‐transcription) polymerase chain reaction for viruses, including human syncytial (HRSVs), influenza (IFVs), parainfluenza (HPIVs), coronaviruses (HCoVs),...
Abstract There are limited data supporting current Centers for Disease Control and Prevention guidelines the isolation period in moderate to severely immunocompromised patients with coronavirus disease 2019 (COVID‐19). Adult COVID‐19 who underwent solid organ transplantation (SOT) or received active chemotherapy against hematologic malignancy were enrolled weekly respiratory samples collected. Samples positive genomic real‐time polymerase chain reaction results virus culture rapid antigen...
Abstract Serological and virological studies were carried out of a mumps outbreak which occurred in one region, Yoeju County, Southeast Seoul Korea from September to December, 1999. Sera 736 children at 8–13 years age patients with healthy tested for mumps‐specific antibodies by enzyme immunoassay. The overall IgM positive rate was 7.6% (56/736), compared 69.8% (514/736) IgG. Of the 49 both IgG IgM, 32 also confirmed clinical serological diagnosis. detected even samples collected up 3 months...
Abstract A multiplex polymerase chain reaction (PCR) assay that is capable of detecting and typing six serotypes respiratory adenovirus (Ad) was developed, using multiple sets type‐specific primers. The detection each different serotype depended on distinguishing numbers sizes amplification products agarose gels following PCR. PCR tested with 26 clinical Ad isolates other viruses including influenza viruses, parainfluenza syncytial as well bacterial pathogens such Chlamydia pneumoniae ,...
Case‐crossover study designs are observational studies used to assess postmarket safety of medical products (eg, vaccines or drugs). As a case‐crossover is self‐controlled, its advantages include better control for confounding because the design controls any time‐invariant measured and unmeasured potentially greater feasibility as only data from those experiencing an event (or cases) required. However, self‐matching also introduces correlation between case periods within subject matched...
Abstract Despite the marked reduction in incidence of measles Korea by introduction vaccine, a large epidemic occurred during 2000–2001. During epidemic, more than 55,000 cases were reported and at least 7 children dead. In this study, we analyzed genetic antigenic properties 15 viruses that isolated epidemic. Sequence analyses entire hemagglutinin (H) nucleoprotein (N) genes indicated all Korean isolates had high degree homology (>99.8%) when compared with each other. They differed from...
Abstract During the influenza pandemic of 2009–2010, rapid diagnostic tests (RIDTs) were used to detect viral infections because they are quick and simple use. However, retrospective studies showed that RIDTs performed poorly when diagnose infections. Determining how amino acid sequence changes in or epidemic antigens impact clinical value has not been possible, epitopes recognized by have mapped. In this study, effect escape‐variations mutations upon sensitivity specificity an RIDT was...
The objective of this study was to examine the impact Food and Drug Administration's boxed warning on utilization depot medroxyprogesterone (DMPA).From IMS Lifelink data (2001-2009), we identified DMPA oral combined hormonal contraceptive (CHC) users without a prescription claim 6 months before after first last claim. Episodes were defined as all contiguous claims with no more than 90-day or 30-day CHC between claims. Days' supply duration (DMPA) used determine episodes. We interrupted time...
Abstract The lower respiratory system serves as the target and barrier for beta‐coronavirus (beta‐CoV) infections. In this study, we explored beta‐CoV infection dynamics in human bronchial epithelial (HBE) organoids, focusing on HCoV‐OC43, SARS‐CoV, MERS‐CoV, SARS‐CoV‐2. Utilizing advanced organoid culture techniques, observed robust replication all beta‐CoVs, particularly noting that SARS‐CoV‐2 reached peak viral RNA levels at 72 h postinfection. Through comprehensive transcriptomic...
Abstract Purpose Develop a flexible analytic tool for the Food and Drug Administration's (FDA's) Sentinel System to assess adherence safe use recommendations with two capabilities: characterize patient monitoring drug, concomitant medication before, during, and/or after drug therapy. Methods We applied in Distributed Database labeled recommendation that patients treated dronedarone undergo electrocardiogram (ECG) testing no less often than every 3 months. Measures of length treatment, time...
The authors have none to declare. FDA approved the study protocol including statistical analysis plan, and reviewed this manuscript. Coauthors from participated in results interpretation preparation decision submit manuscript for publication. had no role data collection, management, or analysis.