A5080102576- Cardiac Arrhythmias and Treatments
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Cardiac electrophysiology and arrhythmias
- SARS-CoV-2 and COVID-19 Research
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- HIV/AIDS Research and Interventions
- Cardiac Imaging and Diagnostics
- COVID-19 Clinical Research Studies
- Cardiovascular Function and Risk Factors
- Respiratory viral infections research
- Virology and Viral Diseases
- Coronary Interventions and Diagnostics
- SARS-CoV-2 detection and testing
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Cervical Cancer and HPV Research
- Cardiovascular Syncope and Autonomic Disorders
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Ion channel regulation and function
- Acute Myocardial Infarction Research
- Herpesvirus Infections and Treatments
Korea Disease Control and Prevention Agency
2014-2023
Korea National Institute of Health
2013-2023
Chonnam National University Hospital
2023
Catholic Kwandong University
1998-2022
Korea University
2022
Hallym University
2020-2022
Ajou University
2022
Korea University Medical Center
2022
National Institute of Infectious Diseases
2022
Korea Center for Disease Control and Prevention
2012-2021
Intracranial hemorrhage rates are higher in Asians than non-Asians, especially patients receiving warfarin. This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke bleeding from Asian non-Asian countries.There were 2782 (15%) 10 countries 15 331 34 countries. A Cox regression model, with terms for treatment, region, their interaction was used.Rates or systemic embolism 3.06% per year warfarin, 2.50%...
Abstract Vaccines and therapeutics are urgently needed for the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we screen human monoclonal antibodies (mAb) targeting receptor binding domain (RBD) of viral spike protein via antibody library constructed from peripheral blood mononuclear cells a convalescent patient. The CT-P59 mAb potently neutralizes SARS-CoV-2 isolates including D614G variant without antibody-dependent enhancement effect. Complex crystal...
Background— During follow-up of between 1 and 3 years in the Randomized Evaluation Long-term Anticoagulation Therapy (RE-LY) trial, 2 doses dabigatran etexilate were shown to be effective safe for prevention stroke or systemic embolism patients with atrial fibrillation. There is a need longer-term on further data comparing doses. Methods Results— Patients randomly assigned RE-LY eligible Multicenter Extension Dabigatran Treatment Atrial Fibrillation (RELY-ABLE) trial if they had not...
Abstract The current coronavirus (COVID-19) pandemic is exacerbated by the absence of effective therapeutic agents. Notably, patients with COVID-19 and comorbidities such as hypertension cardiac diseases have a higher mortality rate. An efficient strategy in response to this issue repurposing drugs antiviral activity for effect. Digoxin (DIG) ouabain (OUA) are FDA heart that against several coronaviruses. Thus, we aimed assess DIG OUA SARS-CoV-2 infection. half-maximal inhibitory...
In Korea, measles occurs mainly in infants <12 months of age, who are unvaccinated. addition, vaccine populations, including adolescents and young adults, can become infected though importation. Thus, the question arises whether current level herd immunity Korea is now insufficient for protecting against infection. Age-specific seroprevalence was evaluated by performing enzyme immunoassays plaque reduction-neutralization tests on 3050 subjects aged 0–50 years (birth cohort 1964–2014) 480...
In 2015, the largest outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection outside occurred in South Korea. We summarized epidemiological, clinical, and laboratory findings first Korean case MERS-CoV analyzed whole-genome sequences derived from patient. A 68-year-old man developed fever myalgia 7 days after returning to Korea, following a 10-day trip East. Before diagnosis, he visited 4 hospitals, potentially resulting secondary transmission 28 patients. On admission...
Abstract Background In contrast to consistent epidemiologic evidence of the role sexual transmission human papillomavirus (HPV) in adults, various routes may be related HPV infection infants. We have assessed extent during perinatal period, and relationship between mode delivery vertical transmission. Results A total 291 pregnant women over 36 weeks gestation were enrolled with informed consent. Exfoliative cells collected from maternal cervix neonatal buccal mucosa. genotypes determined an...
The degree of electroanatomical remodeling the left atrial (LA) affects clinical outcome after rhythm control fibrillation (AF). Our hypothesis was that plasma concentrations transforming growth factor (TGF)-β and tissue inhibitor metalloproteinase (TIMP)-1 reflect LA voltage structural in patients with non-valvular AF.In study, 242 (male 79.4%, 55.1 ± 11.0 years old) AF (155 paroxysmal AF, 87 persistent AF) underwent catheter ablation. Pre-ablation TGF-β TIMP-1 quantified by map (NavX)...
The frequencies of opportunistic diseases (ODs) vary across countries based on genetic, environmental, and social differences. Korean HIV/AIDS cohort study was initiated in 2006 to promote research human immunodeficiency virus (HIV) infection Korea, provide a logistical network support multicenter projects epidemiological, clinical, laboratory aspects HIV infection. This evaluated the prevalence ODs among HIV-infected patients era highly active antiretroviral therapy, risk factors associated...
The prevalence of eight respiratory viruses detected in patients with acute infections (ARIs) Korea was investigated through analysis data recorded by the Influenza and Respiratory Viruses Surveillance System (KINRESS) from 2013 to 2015. Nasal aspirate throat swabs specimens were collected 36 915 ARIs, viral nucleic acids real‐time (reverse‐transcription) polymerase chain reaction for viruses, including human syncytial (HRSVs), influenza (IFVs), parainfluenza (HPIVs), coronaviruses (HCoVs),...
Serosurveillance studies reveal the actual disease burden and herd immunity level in population. In Seoul, Korea, a cross-sectional investigation showed 0.07% anti-severe acute respiratory syndrome coronavirus-2 antibody seropositivity among 1,500 outpatients of university hospitals. Low seroprevalence reflects well-implemented social distancing. should be repeated as pandemic progresses.
There is insufficient data on the longevity of immunity acquired after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Circadian and Seasonal Variation in Early Repolarization Syndrome. Introduction: The circadian seasonal patterns of ventricular tachyarrhythmia (VTA) patients with early repolarization syndrome (ERS) have not been determined. We compared the timing VTAs ERS Brugada (BS). Methods Results: enrolled (n = 14) BS 53) who underwent implantable cardioverter defibrillator (ICD) implantation. VTAs, including cardiac arrest appropriate shocks, was During follow up 6.4 ± 3.6 years group 5.0 3.3 group,...
From the introduction of HIV into Republic Korea in 1985 through 2012, 9,410 HIV-infected Koreans have been identified. Since 2000, there has a sharp increase newly diagnosed Koreans. It is necessary to estimate changes infection plan budgets and modify HIV/AIDS prevention policy. We constructed autoregressive integrated moving average (ARIMA) models forecast number infections from 2013 2017. data 2012 were used fit ARIMA models. Akaike Information Criterion Schwartz Bayesian statistics...
Humanized mouse models derived from immune-deficient mice have been the primary tool for studies of human infectious viruses, such as immunodeficiency virus (HIV). However, current protocol constructing humanized requires elaborate procedures and complicated techniques, limiting supply viral studies. Here, we report a convenient method simple HIV-1 model. Without prior irradiation, NOD/SCID/IL2Rγ-null (NSG) were intraperitoneally injected with 1 × 107 adult peripheral blood mononuclear cells...
With the emergence and rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta Omicron variants, escaping vaccine-induced immunity is a concern. Three vaccination schedules, homologous or heterologous, have been initially applied due to an insufficient supply vaccines in Korea. We investigated neutralizing activities against variants each schedule. schedules using three doses BNT162b2 (BNT) ChAdOx1 (ChAd) include ChAd-ChAd-BNT, ChAd-BNT-BNT, BNT-BNT-BNT....
A review was done on 631 patients with acute myocardial infarction who underwent coronary angiography within 30 days after onset of at Yonsei University Severance Hospital from January, 1985, to August, 1993. The incidence in under 40 years age 10.3% (65/631). Acute below the fourth decades predominant disease men. Risk factor analysis revealed a history cigarette smoking and hypercholesterolemia were more frequently found young patients, but hypertension diabetes elderly patients....