A5101483432- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Hematological disorders and diagnostics
- Antibiotic Resistance in Bacteria
- Multiple Myeloma Research and Treatments
- Digital Imaging for Blood Diseases
- Antibiotic Use and Resistance
- Ginseng Biological Effects and Applications
- Genetics, Bioinformatics, and Biomedical Research
- Glycosylation and Glycoproteins Research
- Molecular Biology Techniques and Applications
- Inflammatory Biomarkers in Disease Prognosis
- Bacterial biofilms and quorum sensing
- Enterobacteriaceae and Cronobacter Research
- Agriculture, Soil, Plant Science
- Microbial infections and disease research
- Respiratory viral infections research
- Machine Learning in Bioinformatics
- Cancer Genomics and Diagnostics
- Neutropenia and Cancer Infections
- Long-Term Effects of COVID-19
- Cancer Immunotherapy and Biomarkers
- Web Applications and Data Management
- Herbal Medicine Research Studies
Hallym University Kangnam Sacred Heart Hospital
2020-2024
Seoul National University
2016-2023
Chungnam National University
2011-2023
Kookmin University
2023
Hallym University
2017-2022
Chonnam National University Hwasun Hospital
2022
Seoul St. Mary's Hospital
2022
Catholic University of Korea
2022
Hangang Sacred Heart Hospital
2017-2019
Chonnam National University Hospital
2018
The spread of COVID-19 pandemic may have affected antibiotic consumption patterns and the prevalence colonized or infected by multidrug-resistant (MDR) bacteria. We investigated differences in antibiotics easily prone to resistance MDR bacteria during (March 2020 September 2021) compared pre-pandemic period 2018 2019). Data on usage infections caused methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), carbapenem-resistant Enterobacteriaceae (CRE),...
We quantitatively analyzed SARS-CoV-2 antibody levels in patients after two doses of the ChAdOx1 nCoV-19 vaccine and third BNT162b2 booster. obtained 255 serum samples from 149 healthcare workers 1 4 months dose. Of participants, 58 (38.9%) experienced COVID-19 infection during 4-month study period, with occurring 7–62 days before second blood draw. Total titers against anti-spike (anti-S) anti-nucleocapsid (anti-N) proteins were measured using Elecsys Anti-SARS-CoV-2 S assays (Roche),...
Serosurveillance studies reveal the actual disease burden and herd immunity level in population. In Seoul, Korea, a cross-sectional investigation showed 0.07% anti-severe acute respiratory syndrome coronavirus-2 antibody seropositivity among 1,500 outpatients of university hospitals. Low seroprevalence reflects well-implemented social distancing. should be repeated as pandemic progresses.
Coinfection rates with other pathogens in coronavirus disease 2019 (COVID-19) varied during the pandemic. We assessed latest prevalence of coinfection viruses, bacteria, and fungi COVID-19 patients for more than one year its impact on mortality. A total 436 samples were collected between August 2020 October 2021. Multiplex real-time PCR, culture, antimicrobial susceptibility testing performed to detect pathogens. The rate respiratory viruses was 1.4%. Meanwhile, bacteria 52.6% 10.5%...
Korean Red Ginseng (KRG) is a functional food and has been well known for keeping good health due to its anti-fatigue immunomodulating activities. However, there no data on red ginseng preventive activity against acute respiratory illness (ARI). The study was conducted in randomized, double-blinded, placebo-controlled trial healthy volunteers (Clinical Trial Number: NCT01478009). Our primary efficacy end point the number of ARI reported secondary severity symptoms, duration ARI. A total 100...
Reliable results regarding serologic positivity for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody before and after AstraZeneca (AZ) vaccination are essential estimating the efficacy of vaccination. We assessed rates associated factors using five SARS-CoV-2 assays. A total 228 paired serum samples (456 samples) were obtained from participants. After baseline sampling, second sampling was conducted between 11 28 days first dose AZ vaccine. Sera tested assays, including...
Abstract Myelodysplastic syndromes (MDS) are a group of hematologic neoplasms accompanied by dysplasia the bone marrow hematopoietic cells with cytopenia. Detecting is important in diagnosis MDS, but it takes considerable time and effort. Also, since assessment subjective difficult to quantify, more efficient tool needed for quality control standardization aspiration smear interpretation. In this study, we developed evaluated an algorithm automatically discriminate cell lineages detect...
This study was conducted to investigate changes in composition of ginsenosides and color processed ginsengs prepared by different steaming-drying times. Processed were from white ginseng with skin 9- time repeated steaming at 96℃ for 3 hours followed hot air-drying 50℃ 24 hours. As the times processes increased, lightness (L value) decreased redness (a increased powders. Crude saponin contents compositions investigated using HPLC method, respecively. according increasing some degree. In case...
Carbapenemase-producing Pseudomonas aeruginosa (CPPA) is a threat to public health. This study aimed describe the first emergence and molecular characterization of NDM-1-producing P. in South Korea. A total 183 carbapenem-resistant (CRPA) isolates were recovered from patients at university hospital Seoul, The antimicrobial resistance genes their genetic environments determined through sequencing. Antimicrobial susceptibility testing was performed using VITEK 2 system broth microdilution...
Data on humoral and cellular responses to BNT162b2 as a booster dose, following two doses of ChAdOx1 nCov-19 vaccine, have seldom been reported. The aim this study was assess the positivity rates three representative antibody assays targeting total, IgG, neutralizing antibodies, an interferon-γ release assay (IGRA), determine longitudinal changes in quantitative titers after each vaccination. A total 1027 samples were collected from healthcare workers. number participants dose 153, they all...
Background: Carbapenem-resistant Pseudomonas aeruginosa (CrPA) is a leading cause of healthcare-associated urinary tract infections (UTIs).Carbapenemase production an important mechanism that significantly alters the efficacy frequently used anti-pseudomonal agents.Reporting current genotypic distribution carbapenemase-producing P. (CPPA) isolates in relation to antimicrobial susceptibility, UTI risk factors, and mortality necessary increase awareness control these strains.Methods: In total,...
Coronavirus disease 2019 (COVID-19) has been a pandemic for the past two years. Predicting patient prognosis is critical. Although immune checkpoints (ICs) were shown to be involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, quantitative studies of ICs clinical practice are limited. In this study, various soluble (sICs) and cytokine levels patients with SARS-CoV-2 infection at different time points compared between survivors deaths; we also examined whether...
Of the existing sepsis markers, immature granulocytes (IG) most frequently reflect presence of an infection. The importance IG as early predictor and bacteremia is evaluated differently for each study. This study aimed to evaluate effectiveness Sysmex XN series' IG% independent prognostic indicator using machine learning.A total 2465 results from 117 severe burn patients in intensive care unit one institution were retrospectively analyzed. We receiver operating characteristic, logistic...
In this study, ginseng flower water extracts were analyzed to set up the ginsenoside content and quality optimization condition. The highest total among was 67.44㎎/g which extracted at 85℃ for 3 hours. addition, decreased according increased extraction temperature time. of Rb<sub>2</sub> Re 37.42㎎/g 75oC 6 Total prosapogenin (Rg<sup>2</sup><sub>+</sub> Rg₃ + Rh<sub>1</sub>) 18.58㎎/g 95℃ 12 sweetness, absorbance But pH
Coronavirus disease 2019 (COVID-19) has been widespread for over four years and progressed to an endemic stage. Accordingly, the evaluation of host immunity in infected patients development markers prognostic prediction early stages have emphasized. Soluble immune checkpoints (sICs), which regulate T cell activity, reported as promising biomarkers viral infections.
Wonkeun Song, M.D., Min-Jeong Park, Seri Jeong, Dong Hoon Shin, Jae-Seok Kim, Hyun Soo Han-Sung Nuri Lee, Jun Sung Hong, Ph.D., and Seok M.D.. Ann Lab Med 2020;40:259-63. https://doi.org/10.3343/alm.2020.40.3.259
The demand for assays that can rapidly and accurately detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains high. We evaluated the performance of two rapid real-time reverse transcription polymerase chain reaction (RT-qPCR) (STANDARD M10 SARS-CoV-2 Xpert Xpress SARS-CoV-2) against conventional RT-qPCR M nCoV Allplex detecting SARS-CoV-2. A total 225 swab samples were collected tested using four assays. STANDARD assay showed 97.4% positive percent agreement (PPA) 100.0%...
FoxP3 is the most dependable marker for regulatory T cells which play a major role in immune tolerance. Foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infections. We studied association severe RRP patients.A total 30 Korean patients 195 healthy controls enrolled. (rs5902434 del/ATT, rs3761548 C/A, rs3761549 C/T, rs2232365 G/A) determined by PCR sequencing.Genotype frequencies (GF) rs5902434 ATT/ATT GG significantly decreased female than (0.0%...
Little is known as to why elevated red cell distribution width (RDW) associated with adverse clinical outcomes in patients atrial fibrillation (AF). We hypothesized that RDW value might predict the intensity of anticoagulation, resulting higher events AF taking warfarin. analyzed 657 non-valuvular who took The anticoagulation was assessed mean time therapeutic range (TTR) and defined TTR ≥60% an optimal intensity. primary end-point composite stroke/systemic embolism major bleeding. secondary...