A5026403363- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Fire effects on ecosystems
- Vector-borne infectious diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Diverse Topics in Contemporary Research
- Dermatological and COVID-19 studies
- Protein Kinase Regulation and GTPase Signaling
- Diverse Approaches in Healthcare and Education Studies
- PI3K/AKT/mTOR signaling in cancer
- Psychosocial Factors Impacting Youth
- Transgenic Plants and Applications
- Influenza Virus Research Studies
- Insect and Pesticide Research
- Hepatitis B Virus Studies
- Peroxisome Proliferator-Activated Receptors
- Viral gastroenteritis research and epidemiology
Korea National Institute of Health
2011-2025
Korea Disease Control and Prevention Agency
2011-2024
Korea Center for Disease Control and Prevention
2011-2020
GeneMatrix (South Korea)
2020
Centers for Disease Control and Prevention
2010
Abstract We investigated the infection rate for severe fever with thrombocytopenia syndrome virus (SFTSV) among ticks collected from humans during May–October 2013 in South Korea. Haemaphysalis longicornis have been considered SFTSV vector. However, we detected H. longicornis, Amblyomma testudinarium, and Ixodes nipponensis ticks, indicating additional potential vectors.
To investigate nationwide severe fever with thrombocytopenia syndrome virus (SFTSV) infection status, we isolated SFTSVs from patients suspected (SFTS) in 207 hospitals throughout South Korea between 2013 and April 2017. A total of 116 were 3137 SFTS-suspected patients, an overall 21.6% case fatality rate. Genetic characterization revealed that at least 6 genotypes co-circulating Korea, multiple reassortments among them. Of these, the genotype B-2 strains most prevalent, followed by F...
During 2013, severe fever with thrombocytopenia syndrome was diagnosed in 35 persons South Korea. Environmental temperature probably affected the monthly and regional distribution of case-patients within country. Phylogenetic analysis indicated that isolates from Korea were closely related to China Japan.
Background/Objectives: Since December 2019, the COVID-19 pandemic, driven by SARS-CoV-2, has caused ~690 million infections globally, manifesting with mild to severe symptoms, including pneumonia. After reduced activity, seasonal influenza re-emerged in winter 2022, creating a “twindemic” SARS-CoV-2. Co-infections have been associated higher risks, such as increased ventilator use and mortality, emphasizing need for dual-target vaccines. This study investigates plant-based vaccines produced...
Abstract We sequenced the envelope (E) gene of 17 strains Japanese encephalitis virus (JEV) isolated in South Korea 1983-2005 and compared sequences with those from previously reported strains. Our results show remarkable genetic stability E sequence Korean JEV Five pairs 10 were identical, despite geographical differences a maximum five-year time span. Sequence comparisons other Asian revealed that are closely related to China, Japan, Vietnam. Genotype 3 predominant before 1993, when...
Serosurveillance studies reveal the actual disease burden and herd immunity level in population. In Seoul, Korea, a cross-sectional investigation showed 0.07% anti-severe acute respiratory syndrome coronavirus-2 antibody seropositivity among 1,500 outpatients of university hospitals. Low seroprevalence reflects well-implemented social distancing. should be repeated as pandemic progresses.
There is insufficient data on the longevity of immunity acquired after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
We isolated Japanese encephalitis virus genotype 5 from human specimens in South Korea. Whole-genome analysis showed 90.4% identity with other viruses humans. This had a unique insertion the NS4A gene. However, envelope protein contained Lys 84, which was specific to strains of
Thiazolidinediones (TZDs), synthetic peroxisome proliferator-activated receptor gamma (PPARgamma) ligands, have been implicated in the inhibition of protein synthesis a variety cells, but underlying mechanisms remain obscure. We report that troglitazone, first TZD drug, acutely inhibited by decreasing p70 S6 kinase (p70S6K) activity bovine aortic endothelial cells (BAEC). This was not accompanied decreased phosphorylation status or vitro mammalian target rapamycin (mTOR). Furthermore,...
In this study, we demonstrated that TBEV-infected ticks have been distributed in the ROK, combined with our previous results. These results suggest TBEV may exist and H. longicornis, flava, I. nipponensis be potential vectors of TBEV. addition, these emphasize need for further epidemiological research We examined presence RNA by reverse transcriptase-nested polymerase chain reaction (RT-nested PCR) using ixodid captured 25 localities 10 provinces. Ticks were collected flagging dragging...
Since the first reported case of severe fever with thrombocytopenia syndrome (SFTS) in South Korea 2013, between 2013 and 2015, we collected 1,697 serum samples from suspected patients who experienced symptoms SFTS. We performed reverse transcriptase polymerase chain reaction using total RNA extracted patients' sera. When viral was detected sera, SFTS diagnosed. Among samples, 170 were positive for virus. then analyzed epidemiologic features these cases. As a result, found that annual number...
Apoptosis has been shown to be induced and downregulated by the Hantaan virus (HTNV) nucleocapsid (N) protein. To address these conflicting data, expression of p53 protein, one key molecules involved in apoptosis, was assessed presence N protein A549 HeLa cells. The amount p53, increased drug treatment, reduced when cells were infected with HTNV or transfected an vector When treated a proteasome inhibitor (MG132) MDM2 antagonist (Nutlin-3), not protein-overexpressed We concluded that...
Hemorrhagic fever with renal syndrome (HFRS) is an infectious disease caused by hantaviruses of the family Bunyaviridae. Among them, Hantaan virus (HTNV) most widely distributed in Korea. The striped field mouse, Apodemus agrarius, natural host HTNV rural We trapped 766 small mammals three species (1 Eothenomys regulus, 13 Crocidura suaveolens, and 752 agrarius) five provinces Korea from January to December 2007. tested 542 rodent sera for antibodies indirect immunofluorescent assay (IFA),...
The seroprevalence of Hantaan virus (HTNV) in wild rodents South Korea was analyzed. Wild were trapped 18 cities eight provinces during 2005-2007 and on three islands four mountains 2008-2010. Sera collected from 629 out 933 animals examined for immunoglobulin G antibodies to HTNV using indirect immunofluorescence assays. Apodemus agrarius (80.1%) the most frequently captured species at almost all trapping sites. overall prevalence 0.26 (162/629). Seropositive individuals more frequent...
Abstract Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV). Although originated in China, it an emerging infectious disease prevalence confirmed Japan, Korea, and Vietnam. The full-length genomes of 51 Korean SFTSV isolates from 2013 to 2016 were sequenced, the sequences deposited into a public database (GenBank) analyzed elucidate phylogeny evolution virus. most closely related previously reported Japanese isolates, some Chinese isolates. We identified one...
Background: There is insufficient data on the longevity of immunity acquired following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to evaluate duration SARS-CoV-2-specific humoral and cellular according clinical severity disease 2019 (COVID-19).Methods: Convalescent blood was collected prospectively from 97 patients who had recovered COVID-19. The level SARS-CoV-2 measured using anti-SARS-CoV-2 nucleocapsid immunoglobulin G (IgG) assay plaque reduction...
Dengue virus (DENV) infection is a public health concern in several countries and associated with severe diseases, such as dengue hemorrhagic fever shock syndrome. DENVs are transmitted to humans via the bites of infected Aedes mosquitoes, no antiviral therapeutics currently available. In this work, we aimed identify drugs against DENV type 2 (DENV2) infections selected pimecrolimus potential drug candidate. Pimecrolimus significantly inhibited DENV2-mediated cell death replication vitro. We...
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging, tick-borne Bandavirus that causes lethal disease in humans. As there are no licensed vaccines and therapeutics for SFTSV, urgent need to develop countermeasures against it. In this respect, a reverse genetics (RG) system powerful tool help achieve goal. Herein, we established T7 RNA polymerase-driven RG rescue infectious clones of Korean SFTSV human isolate entirely from complementary DNA (cDNA). To establish system,...