A5070111980- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Xenotransplantation and immune response
- Viral Infections and Vectors
- Animal Genetics and Reproduction
- Influenza Virus Research Studies
- Advanced biosensing and bioanalysis techniques
- Cervical Cancer and HPV Research
- vaccines and immunoinformatics approaches
- HIV Research and Treatment
- Viral gastroenteritis research and epidemiology
- Nanoplatforms for cancer theranostics
- Monoclonal and Polyclonal Antibodies Research
- Reproductive System and Pregnancy
- Computational Drug Discovery Methods
- Graphene and Nanomaterials Applications
- Biochemical and Molecular Research
- HIV/AIDS drug development and treatment
- Mathematical Dynamics and Fractals
- Nanoparticle-Based Drug Delivery
Konkuk University
2015-2024
STR Biotech (South Korea)
2022-2024
Konkuk University Medical Center
2009-2023
Pukyong National University
2022
Bio-Medical Science (South Korea)
2021
Korea National Institute of Health
2020
Gyeongsangnam-do Agricultural Research and Extension Services
2020
Government of the Republic of Korea
2015
Yonsei University
2003
Korea Advanced Institute of Science and Technology
1993-1998
Influenza is an infectious respiratory disease with frequent seasonal epidemics that causes a high rate of mortality and morbidity in humans, poultry, animals. serious economic concern due to the costly countermeasures it necessitates. In this study, we compared antiviral activities several flavonols other flavonoids similar, but distinct, hydroxyl or methyl substitution patterns at 3, 3', 4' positions 15-carbon flavonoid skeleton, found strongest effect was induced by isorhamnetin. Similar...
Alzheimer's disease (AD) is one of the progressive neurodegenerative diseases characterized by β-amyloid (Aβ) production and Phosphorylated-Tau (p-Tau) protein in cerebral cortex. The precise mechanisms cause, responsible for pathology progression, are not well understood because there multiple risk factors associated with disease. Viral infection AD, we demonstrated that Zika virus (ZIKV) brain organoids could trigger AD pathological features, including Aβ p-Tau expression. AD-related...
A correlation between COVID-19 and Alzheimer's disease (AD) has been proposed recently. Although the number of case reports on neuroinflammation in patients increased, studies SARS-CoV-2 neurotrophic pathology using brain organoids have restricted recapitulation those phenotypes due to insufficiency immune cells absence vasculature. Cerebral pericytes endothelial cells, major components blood-brain barrier, express viral entry receptors for response systemic inflammation including direct...
Pandemic influenza poses a serious threat to global health and the world economy. While vaccines are currently under development, passive immunization could offer an alternative strategy prevent treat virus infection. Attempts develop monoclonal antibodies (mAbs) have been made. However, based on mAbs may require cocktail of with broader specificity in order provide full protection since generally specific for single epitopes. Chicken immunoglobulins (IgY) found egg yolk used mainly...
To confirm that Korean Food and Drug Administration (KFDA) guidelines are applicable to test the efficacy of mosquito repellents, these were used complete protection times (CPTs) three representative repellents: N,N-diethyl-3-methylbenzamide (DEET), citronella, fennel oil. The repellency citronella oil decreased over time, from 97.9% at 0 h 71.4% 1 57.7% 2 h, as did oil, 88.6% 61.2% 47.4% h. In contrast, DEET remained 90% for 6 CPT (360 min) was much longer than CPTs (10.5 (8.4 min). These...
Placenta, as a reservoir of nutrients, has been widely used in medical and cosmetic materials. Here, we focused on the antioxidant properties placental extract attempted to isolate identify main factors. Porcine extracts were prepared through homogenization or acid hydrolysis, their activity was investigated human keratinocyte HaCaT cell line. Treatment with homogenized (H-PE) increased viability H2O2-treated cells more than two-fold. H-PE treatment suppressed H2O2-induced apoptotic necrotic...
Humanized mouse models derived from immune-deficient mice have been the primary tool for studies of human infectious viruses, such as immunodeficiency virus (HIV). However, current protocol constructing humanized requires elaborate procedures and complicated techniques, limiting supply viral studies. Here, we report a convenient method simple HIV-1 model. Without prior irradiation, NOD/SCID/IL2Rγ-null (NSG) were intraperitoneally injected with 1 × 107 adult peripheral blood mononuclear cells...
The imbalanced expression of matrix metalloproteinases (MMPs) is associated with liver fibrosis, one the most common chronic diseases. Enhanced MMPs by gene therapy emerging as a promising antifibrotic strategy, but effectiveness this approach depends on reliable systems for delivering MMP genes. Here, we evaluated newly designed hyaluronic acid (HA)-shielded delivery system systemic administration plasmid DNA encoding MMP13 (pMMP13), and tested whether enhanced ameliorates fibrosis in mice....
Abstract Here we report a recombinant baculoviral vector-based DNA vaccine system against Middle East respiratory syndrome coronavirus (MERS-CoV) and the severe acute coronavirus-2 (SARS-CoV2). A non-replicating baculovirus expressing human endogenous retrovirus envelope gene (AcHERV) was constructed as vector for delivery into cells. For MERS-CoV construction, encoding S-full, S1 subunit, or receptor-binding domain (RBD) inserted genome of AcHERV. COVID19 SARS-CoV2 S-full NTD domain-fused...
Neutralizing antibody (NAb) detection is critical for evaluating herd immunity and monitoring the efficacy of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, quantitative SARS-CoV-2 levels after vaccination were measured by chemiluminescent immunoassays, enzyme surrogate virus neutralization tests (sVNTs), as well plaque reduction (PRNT). Sequential blood samples collected before 1 3 months in 30 healthy participants (two doses Oxford-AstraZeneca...