A5067843398- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- CRISPR and Genetic Engineering
- Photodynamic Therapy Research Studies
- Graphene research and applications
- Mesenchymal stem cell research
- Lipid Membrane Structure and Behavior
- Dendrimers and Hyperbranched Polymers
- Cancer Research and Treatments
- DNA and Nucleic Acid Chemistry
- Phagocytosis and Immune Regulation
- Gold and Silver Nanoparticles Synthesis and Applications
- Carbon and Quantum Dots Applications
- Cannabis and Cannabinoid Research
- Silk-based biomaterials and applications
- Hepatitis B Virus Studies
- Nanocluster Synthesis and Applications
- Molecular Communication and Nanonetworks
Soongsil University
2020-2025
Government of the Republic of Korea
2015-2024
Seoul National University
2012-2020
Seoul Institute
2020
Instytut Farmaceutyczny
2015
Korea University
2007-2012
Despite the progress of conventional vaccines, improvements are clearly required due to concerns about weak immunogenicity these intrinsic instability in vivo, toxicity, and need for multiple administrations. To overcome such problems, nanotechnology platforms have recently been incorporated into vaccine development. Nanocarrier-based delivery systems offer an opportunity enhance humoral cellular immune responses. This advantage is attributable nanoscale particle size, which facilitates...
Although immune checkpoint inhibitors have emerged as a breakthrough in cancer therapy, monotherapy approach is not sufficient. Here, we report an inhibitor-modified nanoparticle for situ-assembled tumor vaccine that can activate systems the microenvironment and prevent long-term recurrence of tumors. Adjuvant-loaded nanoparticles were prepared by entrapping imiquimod (IQ) photoresponsive polydopamine (IQ/PNs). The surfaces IQ/PNs then modified with anti-PDL1 antibody (PDL1Ab-IQ/PNs) situ...
Nucleic acid-based bioactive substances have recently emerged as a new class of next-generation therapeutics, but their development has been limited by relatively weak delivery into target cells. Cationic liposomes studied means to enhance the stability nucleic acid therapeutics in bloodstream and improve cellular delivery. As siRNA plasmid DNA extensively tested for using cationic liposomes. This review discusses recent progress application therapeutics.
Abstract In liver fibrosis, activated hepatic stellate cells are known to overexpress fibroblast activation protein. Here we report a targeted antifibrotic peptide-delivery system in which protein, is overexpressed fibrotic regions of the liver, liberates peptide melittin by cleaving protein-specific site peptide. The promelittin linked pegylated and maleimide-functionalized liposomes, resulting promelittin-modified liposomes. liposomes were effective reducing viability but not that control...
Photothermal immunotherapy has emerged as one of the most potent approaches for cancer treatment, but this strategy suffered from lack biodegradability photoresponsive materials. In study, we aimed to develop biodegradable materials photothermal immunotherapy. To end, designed a DNA CpG hydrogel (DH, generated by rolling-circle amplification), loaded it with bis-(3′-5′)-cyclic dimeric guanosine monophosphate (G/DH), and coated formulation melanin (Mel/G/DH). Mel/G/DH exhibited temperature...