A5080803960- Lipid metabolism and biosynthesis
- Photosynthetic Processes and Mechanisms
- Lipid Membrane Structure and Behavior
- Exercise and Physiological Responses
- Endoplasmic Reticulum Stress and Disease
- Graphite, nuclear technology, radiation studies
- Palliative Care and End-of-Life Issues
- Retinoids in leukemia and cellular processes
- Healthcare Education and Workforce Issues
- GaN-based semiconductor devices and materials
- Diverse Approaches in Healthcare and Education Studies
- Nuclear and radioactivity studies
- Meat and Animal Product Quality
- Pain Management and Opioid Use
- Aldose Reductase and Taurine
- ZnO doping and properties
- Semiconductor Quantum Structures and Devices
- Health and Wellbeing Research
- Advanced Semiconductor Detectors and Materials
- Gastrointestinal Tumor Research and Treatment
- Signaling Pathways in Disease
- Radioactive contamination and transfer
- Food Quality and Safety Studies
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
University of Chicago
2018-2025
Seoul National University
1998-2023
D. E. Shaw Research
2023
Kyung Hee University Medical Center
2007-2022
Dongguk University
2019-2022
Konkuk University
2010-2019
Korea Electric Power Corporation (South Korea)
2010-2019
Korea Hydro and Nuclear Power (Korea)
2010-2019
Kangwon National University Hospital
2019
Kyung Hee University
1998-2017
ADVERTISEMENT RETURN TO ISSUECommunicationNEXTDirect Synthesis of Six-Monolayer (1.9 nm) Thick Zinc-Blende CdSe Nanoplatelets Emitting at 585 nmWooje ChoWooje ChoDepartment Chemistry, University Chicago, Illinois 60637, United StatesMore by Wooje Cho, Siyoung KimSiyoung KimInstitute for Molecular Engineering, Kim, Igor CoropceanuIgor CoropceanuDepartment Coropceanu, Vishwas SrivastavaVishwas SrivastavaDepartment Srivastava, Benjamin T. DirollBenjamin DirollCenter Nanoscale Materials, Argonne...
Lipid droplets (LDs) are organelles formed in the endoplasmic reticulum (ER) to store triacylglycerol (TG) and sterol esters. The ER protein seipin is key for LD biogenesis. Seipin forms a cage-like structure, with each monomer containing conserved hydrophobic helix two transmembrane (TM) segments. How different parts of function TG nucleation budding poorly understood. Here, we utilized molecular dynamics simulations human seipin, along cell-based experiments, study seipin’s functions...
In this paper, a new type of AC/AC power converter is proposed. The proposed capable direct conversion and, except for few small snubber elements, it does not require the use any input inductors or DC-link capacitor. contrast to matrix converter, which requires bidirectional switches, consists only unidirectional switches such as insulated gate bipolar transistors. has unity displacement factor, and its line current waveform similar that diode rectifier with inductor. been validated...
Korean nuclear power plants (NPPs) periodically evaluate the radioactive gaseous and liquid effluents released from reactors to protect public radiation exposure. This paper provides a comprehensive overview of release NPPs effects on annual doses public. The amounts environment resulting members living around were analyzed for years 2011–2015 using Korea Hydro & Nuclear Power Co., Ltd's summary reports assessment radiological impact environment. results show that tritium was primary...
Abstract Hypoimmunogenic universal induced pluripotent stemn (iPS) cells were generated through the targeted disruption of key genes, including human leukocyte antigen ( HLA )- A , HLA-B and HLA-DR alpha DRA ), using CRISPR–Cas9 system. This approach aimed to minimize immune recognition enhance potential iPS for allogeneic therapy. Heterozygous used guide RNA design validation facilitate knockout (KO) HLA-A HLA-DRA genes. The electroporation selected RNAs enabled generation triple-KO cells,...
Coarse-grained (CG)molecular dynamics is a powerful tool for simulating the collective behavior of biomolecules. However, structural information lost during coarse-graining prevents CG configurations from being more widely useful (e.g., ligand binding). Regenerating allatom coordinates, or backmapping, an unmet challenge proteins at resolutions lower than one coarse-grain site bead per amino acid residue. This low resolution computationally necessary to simulate many protein complexes...
Lipid droplets (LDs) are neutral lipid storage organelles surrounded by a phospholipid (PL) monolayer. LD biogenesis from the endoplasmic reticulum is driven phase separation of lipids, overcoming surface tension and membrane deformation. However, core biophysics initial steps formation remains relatively poorly understood. Here, we use tunable, phenomenological coarse-grained model to study triacylglycerol (TG) nucleation in bilayer membrane. We show that PL rigidity has strong influence on...
Cells remodel glycerophospholipid acyl chains via the Lands cycle to adjust membrane properties. Membrane-bound O-acyltransferase (MBOAT) 7 acylates lyso-phosphatidylinositol (lyso-PI) with arachidonyl-CoA. MBOAT7 mutations cause brain developmental disorders, and reduced expression is linked fatty liver disease. In contrast, increased hepatocellular renal cancers. The mechanistic basis of catalysis substrate selectivity are unknown. Here, we report structure a model for catalytic mechanism...
The objective of this study was to examine the effect ginger extract (GE) combined with citric acid on tenderness duck breast muscles. Total six marinades were prepared combination (0 and 0.3 M acid) GE (0, 15, 30%). Each marinade sprayed surface breasts (15 mL/100 g), samples marinated for 72 h at 4℃. pH proteolytic activity determined. After marination, Warner Bratzler shear force (WBSF), myofibrillar fragmentation index (MFI), pH, cooking loss, moisture content, sodium dodecyl...
Lipid droplets (LDs) are intracellular storage organelles composed of neutral lipids, such as triacylglycerol (TG), surrounded by a phospholipid (PL) monolayer decorated with specific proteins. Herein, we investigate the mechanism protein association during LD and bilayer membrane expansion. We find that lipids play dynamic role in expansion further intercalating PL to create more surface-oriented TG molecules (SURF-TG). This interplay both reduces high surface tension incurred budding or...
The objective of this study was to investigate the effects replacing sucrose with sugar alcohols (sorbitol, glycerol and xylitol) on quality properties semi-dried jerky. Total 7 treatments jerkies were prepared as follows: control sucrose, 2.5 5.0% replaced by each alcohol, respectively. Drying yield, pH, water activity, moisture content, shear force, myofibrillar fragmentation index (MFI), 2-thiobarbituric acid reactive substance (TBARS) value, sensory evaluation evaluated. Xylitol slightly...
Abstract Integrated early palliative care ( EPC ) improves quality of life and reduces psychological distress in adult patients with cancer caregivers, but attitudes toward have been poorly studied. We aimed to investigate a nationwide survey caregivers. From July October 2016, we administered questionnaires examining n = 1001) their families 1006) from 12 Korean hospitals. When an individual considered unnecessary, the reasons were collected analyzed. Factors associated perception examined....
Abstract It has been reported that hypomagnetic fields (HMFs) have a negative influence on mammalian physiological functions. We previously HMFs were detrimental to cell fate changes during reprogramming into pluripotency. These studies led us investigate whether affect determination direct differentiation. Here, we found an HMF environment attenuates differentiation capacity and is the in vitro of embryonic stem cells (ESCs). Moreover, conditions cause abnormal DNA methylation through...
Abstract Background The ε4 allele of apolipoprotein E ( APOE ε4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD), associated with amyloid pathogenesis. However, it not clear how accelerates amyloid-beta (Aβ) deposition during seeding stage development in AD patient neurons. Methods induced neurons (iNs) an inducible system were prepared from skin fibroblasts patients. Transcriptome analysis was performed using RNA isolated iNs expressing at amyloid-seeding...