A5043691202- Alzheimer's disease research and treatments
- Dermatology and Skin Diseases
- Neurogenesis and neuroplasticity mechanisms
- Mast cells and histamine
- Innovative Microfluidic and Catalytic Techniques Innovation
- Reproductive System and Pregnancy
- Ultrasound and Hyperthermia Applications
- 3D Printing in Biomedical Research
- Endoplasmic Reticulum Stress and Disease
- Mosquito-borne diseases and control
- Cholinesterase and Neurodegenerative Diseases
- Lysosomal Storage Disorders Research
- Tryptophan and brain disorders
- Immune cells in cancer
- Infant Nutrition and Health
- Exercise and Physiological Responses
- Mitochondrial Function and Pathology
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Long-Term Effects of COVID-19
- Cell Adhesion Molecules Research
- Pluripotent Stem Cells Research
- Phagocytosis and Immune Regulation
- Photoacoustic and Ultrasonic Imaging
Seoul National University
2020-2025
Mitochondrial dysfunction is associated with familial Alzheimer's disease (fAD), and the accumulation of damaged mitochondria has been reported as an initial symptom that further contributes to progression. In amyloidogenic pathway, amyloid precursor protein (APP) cleaved by β-secretase generate a C-terminal fragment, which then γ-secretase produce amyloid-beta (Aβ). The Aβ its detrimental effect on mitochondrial function are well known, yet protein-derived fragments (APP-CTFs) contributing...
Alzheimer's disease (AD) is one of the progressive neurodegenerative diseases characterized by β-amyloid (Aβ) production and Phosphorylated-Tau (p-Tau) protein in cerebral cortex. The precise mechanisms cause, responsible for pathology progression, are not well understood because there multiple risk factors associated with disease. Viral infection AD, we demonstrated that Zika virus (ZIKV) brain organoids could trigger AD pathological features, including Aβ p-Tau expression. AD-related...
A correlation between COVID-19 and Alzheimer's disease (AD) has been proposed recently. Although the number of case reports on neuroinflammation in patients increased, studies SARS-CoV-2 neurotrophic pathology using brain organoids have restricted recapitulation those phenotypes due to insufficiency immune cells absence vasculature. Cerebral pericytes endothelial cells, major components blood-brain barrier, express viral entry receptors for response systemic inflammation including direct...
Abstract Atopic dermatitis (AD) is a chronic and inflammatory disease. According to recent study, administration of canine MSCs potential therapy for immunological diseases. However, most related studies involve short-term experiments acute atopic animal models. Thus, repeated subcutaneous injection ameliorating long-term skin disorders have not yet been established. In this we evaluated the effects amniotic mesenchymal stem cells (cAM-MSCs) calcineurin inhibitors (CNIs) treatments in mouse...
Three-dimensional (3D) bioprinting is a promising technology to establish 3D in vitro hepatic model that holds great potential toxicological evaluation. However, current models, the central area suffers from hypoxic conditions, resulting slow and weak metabolism of drugs toxins. It remains challenging predict accurate drug effects bioprinted models. Here, we constructed hexagonal construct incorporated spinning condition with continuous media stimuli. Under HepG2 cells exhibited enhanced...
Alzheimer's disease (AD) is one of the most well-known neurodegenerative diseases, with a substantial amount advancements in field neuroscience and AD. Despite such progress, there has been no significant improvement AD treatments. To improve developing research platform for treatment, patient-derived induced pluripotent stem cell (iPSC) was employed to generate cortical brain organoids, expressing phenotypes, accumulation amyloid-beta (Aβ) hyperphosphorylated tau (pTau). We have...
Recent studies on developing three-dimensional (3D) brain organoids from stem cells have allowed the generation of in vitro models neural disease and enabled screening drugs because these mimic complexity tissue. Niemann-Pick disease, type C (NPC) is a neurodegenerative lysosomal storage disorder caused by mutations NPC1 or NPC2. The pathological features underlying NPC are characterized abnormal accumulation cholesterol acidic compartments, including late endosomes lysosomes. Due to...
Abstract As modeling of atherosclerosis requires recapitulating complex interactions with vasculature and immune cells, previous in vitro models have limitations due to their insufficient 3D vascular structures. However, induced pluripotent stem cell‐derived blood vessel organoids (BVOs) are applicable for diseases, containing multiple cell types, including endothelial smooth muscle cells self‐assembled into a structure. Atherosclerotic BVOs microenvironment associated atherogenesis, such as...
Human mesenchymal stem cells (hMSCs) therapy has recently been considered a promising treatment for atopic dermatitis (AD) due to their immunomodulation and tissue regeneration ability. In our previous studies, we demonstrated that hMSCs alleviate allergic inflammation in murine AD model by inhibiting the activation of mast B cells. Also phase I/IIa clinical trial showed efficacy safety moderate-to-severe adult patients. However, against have had poor results field. Therefore, investigated...