A5073634418- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Osteoarthritis Treatment and Mechanisms
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Neurological Disorders and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Graphene and Nanomaterials Applications
- Tendon Structure and Treatment
- Cellular Mechanics and Interactions
- Biochemical effects in animals
- Cancer Cells and Metastasis
- Pluripotent Stem Cells Research
- Bone and Dental Protein Studies
- Congenital heart defects research
- Knee injuries and reconstruction techniques
- SARS-CoV-2 and COVID-19 Research
- Bone Tissue Engineering Materials
- Foot and Ankle Surgery
- Autoimmune and Inflammatory Disorders Research
- Neonatal Respiratory Health Research
- COVID-19 Clinical Research Studies
- Rheumatoid Arthritis Research and Therapies
- Carbon and Quantum Dots Applications
National Center for Biotechnology
2018-2024
Nazarbayev University
2021-2022
Three-dimensional (3D) bioprinting is a promising technology to establish 3D in vitro hepatic model that holds great potential toxicological evaluation. However, current models, the central area suffers from hypoxic conditions, resulting slow and weak metabolism of drugs toxins. It remains challenging predict accurate drug effects bioprinted models. Here, we constructed hexagonal construct incorporated spinning condition with continuous media stimuli. Under HepG2 cells exhibited enhanced...
The repair of critical-sized calvarial defects is a challenging problem for orthopedic surgery. One the promising strategies bone bioengineering to enhance efficacy large defect regeneration combined delivery stem cells with osteoinductive factors within polymer carriers. purpose research was study regenerative effects heparin-conjugated fibrin (HCF) hydrogel containing morphogenetic protein 2 (BMP-2) and adipose-derived pericytes (ADPs) in rat model. In vitro analysis revealed that HCF able...
Biomechanical properties of mammalian bones, such as strength, toughness, and plasticity, are essential for understanding how microscopic-scale mechanical features can link to macroscale bones' strength fracture resistance. We employ Brillouin light scattering (BLS) microspectroscopy local assessment elastic bones under compression the efficacy tissue engineering approach based on heparin-conjugated fibrin (HCF) hydrogels, bone morphogenic proteins, osteogenic stem cells in regeneration...
The regeneration of cartilage and osteochondral defects remains one the most challenging clinical problems in orthopedic surgery. Currently, tissue-engineering techniques based on delivery appropriate growth factors mesenchymal stem cells (MSCs) hydrogel scaffolds are considered as promising therapeutic strategy for regeneration. In this study, we fabricated a heparin-conjugated fibrin (HCF) with synovium-derived (SDMSCs), transforming factor-β1 (TGF-β1) bone morphogenetic protein-4 (BMP-4)...
Introduction The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has had an unprecedented impact on people around the world, particularly those who were suffering from autoimmune rheumatic diseases (AIRDs). world community acknowledges significance of COVID-19 vaccination in patients with disorders and emphasizes priority this category to receive over general population. Although many studies have been published since first phases all multiple related factors still need be...
Pericytes, as perivascular cells, are present in all vascularized organs and tissues, they actively interact with endothelial cells capillaries microvessels. Their involvement includes functions like blood pressure regulation, tissue regeneration, scarring.
 Studies have confirmed that pericytes play a crucial role bone regeneration through direct osteodifferentiation processes, paracrine actions, vascularization. Recent pre-clinical clinical experiments shown combining osteogenic...
Using autologous mesenchymal stem cells, 12 patients with pathology of the knee joint cartilage were successfully treated. At first stage, all underwent traditional arthroscopic debridement, during which a sample synovium was taken, after transferred to National Center for Biotechnology cultivation cells. After culturing therapeutically effective number material punctured into cavity affected joint. Evaluation results demonstrated positive effect method on course disease.
Abstract Graphene quantum dots (GQDs) have been found to promote the efficient differentiation of stem cells into a variety cell types. However, their bioactivity and signaling mechanisms in hepatic lineage not fully investigated. Here, we report that hepatoblast (HB) rate can be promoted by using Ca 2+ -rich coffee bean (CB)-derived GQDs, where incorporated calcium ions activate insulin-like growth factor 1 receptor (IGF1R)-protein kinase B (AKT). We also human pluripotent (hPSC)-derived...
Regeneration of damaged articular cartilage remains one the most complex and unresolved problems in traumatology orthopedics. In this study, we investigated whether intra-articular injection synovium-derived mesenchymal stem cells (SD-MSCs) with low molecular weight hyaluronic acid (LMWHA) could promote regeneration rabbits. To answer question, rabbits' SD-MSCs were harvested, expanded culture, characterized by CFU assay a multilineage differentiation test. For vivo created defect within...
Currently, one of the major focuses in regenerative medicine is development and implementation into practice composite biomaterials with chondro- osteoinductive properties, which include human stem cells growth factors. Heparin-conjugated fibrinogen was obtained using carbodiimide method, further used to create heparin-conjugated fibrin hydrogels (HCFH). As a result this work, two types HCFH were obtained: hydrogel encapsulated mesenchymal (MSC) TGF-β1 BMP-4 It has been found that synovial...