A5058917322- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- RNA Interference and Gene Delivery
- Ultrasound and Hyperthermia Applications
- Nanoplatforms for cancer theranostics
- Connective tissue disorders research
- Lipid Membrane Structure and Behavior
- Advanced Drug Delivery Systems
- Advanced biosensing and bioanalysis techniques
- Dendrimers and Hyperbranched Polymers
- Graphene and Nanomaterials Applications
- MicroRNA in disease regulation
- Proteoglycans and glycosaminoglycans research
- Neuropeptides and Animal Physiology
- 3D Printing in Biomedical Research
- Blood properties and coagulation
- Bone and Joint Diseases
- Characterization and Applications of Magnetic Nanoparticles
- Proteins in Food Systems
- Traumatic Brain Injury and Neurovascular Disturbances
- Receptor Mechanisms and Signaling
- Antimicrobial Peptides and Activities
- Advancements in Transdermal Drug Delivery
- Synthesis and Biological Evaluation
- Protein Interaction Studies and Fluorescence Analysis
Samsung (South Korea)
2012-2017
Seoul Institute
2017
Government of the Republic of Korea
2017
Centre National de la Recherche Scientifique
2003-2010
Université Paris-Sud
2005-2010
Korea Advanced Institute of Science and Technology
2008
Institut Galien Paris-Saclay
2007
Sorbonne Université
2003
Abstract The biodistribution of colloidal carriers after their administration in vivo depends on the adsorption some plasma proteins and apolipoproteins surface. Poly(methoxypolyethyleneglycol cyanoacrylate‐ co ‐hexadecylcyanoacrylate) (PEG‐PHDCA) nanoparticles have demonstrated capacity to cross blood–brain barrier (BBB) by a mechanism endocytosis. In order clarify this at molecular level, especially adsorbed surface PEG‐PHDCA were analyzed complementary methods such as CE Protein...
Cationic solid lipid nanoparticles (SLN), reconstituted from natural components of protein-free low-density lipoprotein, were used to deliver small interfering RNA (siRNA). The cationic SLN was prepared using a modified solvent-emulsification method. composition 45% (w/w) cholesteryl ester, 3% triglyceride, 10% cholesterol, 14% dioleoylphosphatidylethanolamine (DOPE), and 28% 3β-[N-(N′,N′-dimethylaminoethane)carbamoyl]-cholesterol (DC-chol). had mean diameter 117 ± 12 nm surface zeta...
Chemotherapeutic drugs are traditionally used for the treatment of cancer. However, chemodrugs generally induce side effects and decrease anticancer due to indiscriminate diffusion poor drug delivery. To overcome these limitations chemotherapy, in this study, ultrasound-responsive liposomes were fabricated as carriers delivering doxorubicin, which was able cancer cell death. The ultrasound-sensitive liposome demonstrated a size distribution 81.94 nm, entrapment efficiency doxorubicin 97.1 ±...
Monitoring of drug release from a heat-activated liposome carrier provides an opportunity for real-time control delivery and allows prediction the therapeutic effect. We have developed short-chain elastin-like polypeptide-incorporating thermosensitive liposomes (STLs). Here, we report development STL encapsulating gadobenate dimeglumine (Gd-BOPTA), MRI contrast agent, doxorubicin (Dox) (Gd-Dox-STL). The Dox profile Gd-Dox-STL was comparable to Gd-Dox-LTSL; however, serum stability much...
One application of nanotechnology in medicine that is presently being developed involves a drug delivery system (DDS) employing nanoparticles to deliver drugs diseased sites the body avoiding damage healthy tissue. Recently, mild hyperthermia-triggered combined with anticancer agent-loaded thermosensitive liposomes was widely investigated. In this study, (TSLs), composed 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC),...
Because chemotherapeutic drugs are often associated with serious side effects, the central topic in modern drug delivery is maximizing localization of at target while minimizing non-specific interactions unwanted regions. To address this issue, biocompatible nanoparticles have been developed to enhance half-life toxicity. Nevertheless, relying solely on enhanced and permeability retention (EPR) effects has ineffective, designing stimulus-sensitive introduce precise control release desired....
Heparin decomplexation experiments, as well all-atom (AA) and coarse-grained (CG) molecular dynamics (MD) simulations, were performed to determine the effect of size arginine(Arg)-rich peptides on structure binding strength siRNA–peptide complex. At a fixed peptide/siRNA mole ratio 5:1 or 10:1, siRNA complexes with longer than nine Arg residues are more easily decomplexed by heparin those residues. these ratios, have cationic/anionic charge ratios in excess unity, produce weakly bound...
We performed all-atom and coarse-grained (CG) molecular dynamics (MD) simulations of lipid bilayers grafted with elastin-like polypeptides (ELPs; [VPGVG]n). All-atom a single ELP in water show that ELPs become more collapsed folded as the temperature increases from 293 up to 353 K, agreement experiments. composed dipalmitoylglycerophosphocholine (DPPC), cholesterol, fatty acids insert into bilayer significantly disorder lipids, an extent depends on length over range 293–323 K. In bilayer,...
Lipid bilayers, which consist of dipalmitoylglycerophosphocholines (DPPCs), PEGylated lipids, cholesterols, and elastin-like polypeptides (ELPs; [VPGVG]3) at different molar ratios, were simulated. Simulations carried out for 2 μs using the coarse-grained (CG) model that had captured experimentally observed phase behavior lipids lateral diffusivity DPPC bilayers. Starting with initial position ELPs on bilayer surface, insert into hydrophobic region because their interaction lipid tails,...
High intensity focused ultrasound (HIFU), allowing for precise heating of the deep and local area, is emerging as source mild hyperthermia delivery doxorubicin (DOX) using thermosensitive liposomes (TSLs). Conventionally, HIFU has been used intravascular drug release at tumor tissue by inducing immediately upon systemic administration DOX-TSLs. This immediate approach (IHA), however, limits penetration DOX high anticancer efficacy. In an attempt to maximize accumulation tumor, delayed (DHA)...
Non-thermal acoustic treatment led to higher tissue penetration without permanent vascular damage and greater intratumoral drug accumulation than thermal treatment.
We perform coarse-grained molecular dynamics simulations of bilayers composed various lipids and cholesterol at their different ratios. Simulations show that cholesterol-lipid interactions restrict the lateral but also promote bilayer curvature, indicating these opposite effects simultaneously occur thus cannot significantly influence stability. In contrast, lyso-lipids effectively pack vacancy in cone-shaped reduce showing are more stabilized by than cholesterol, agreement with experiments....
Doxorubicin (DOX) is a representative anticancer drug with unique ability to induce immunogenic cell death of cancer cells. However, undesired toxicity on immune cells has remained significant challenge, hindering the usage DOX in immunotherapy. Here, we report combined therapy avoid off-target by adapting ultrasound-responsive liposomal doxorubicin and focused ultrasound exposure. Histological analysis demonstrated that induced less hemosiderosis splenocytes improved tumor infiltration...