A5062229729- Nanoplatforms for cancer theranostics
- Force Microscopy Techniques and Applications
- Advancements in Photolithography Techniques
- Molecular Junctions and Nanostructures
- Integrated Circuits and Semiconductor Failure Analysis
- Photoacoustic and Ultrasonic Imaging
- Nanofabrication and Lithography Techniques
- Near-Field Optical Microscopy
- Analytical Chemistry and Sensors
- Semiconductor materials and devices
- Nanoparticle-Based Drug Delivery
- Electrochemical Analysis and Applications
- Advanced Surface Polishing Techniques
- Ultrasound and Hyperthermia Applications
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Advances in Cucurbitaceae Research
- Nanoparticles: synthesis and applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Surface Roughness and Optical Measurements
- Extracellular vesicles in disease
- Mechanical and Optical Resonators
- Optical Coatings and Gratings
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
Sungkyunkwan University
2007-2024
Samsung (South Korea)
2011-2023
Sejong University
2022-2023
Government of the Republic of Korea
2018-2021
Suwon Research Institute
2018
Seoul National University
2005-2010
Samsung Medical Center
2007
Kwangwoon University
2006
Abstract Necroptosis, caspase‐independent programmed necrosis, has emerged as a therapeutic target to make dying cancer cells stimulants for antitumor immune responses. The clinical translations exploiting necroptosis, however, have been limited since most downregulate receptor‐interacting protein kinase 3 (RIPK3) key enzyme necroptosis. Herein, nanobubbles (NBs) that can trigger RIPK3‐independent facilitating cell‐membrane rupture via the acoustic cavitation effect are reported. NBs,...
Silver particles are used in various consumer products due to their positive effects, which include sterilization and antibacterial properties. However, it has been reported that silver nanoparticles (AgNPs) have strongly acute toxic effects on cells. Therefore, the cytotoxicity of AgNPs was investigated, using Escherichia coli as a model organism, from standpoint three key metrics (ionic ratio, size, agglomeration) most relevant physicochemical The findings indicated is depressed by...
Conventional cancer targeting with nanoparticles has been based on the assumed enhanced permeability and retention (EPR) effect. The data obtained in clinical trials to date, however, have rarely supported presence of such an To address this challenge, we formulated intracellular nitric oxide-generating (NO-NPs) for tumor site-specific delivery NO, a well-known vasodilator, intention boosting EPR. These are self-assembled under aqueous conditions from amphiphilic copolymers poly(ethylene...
Chemiluminescence (CL) has recently gained attention for CL resonance energy transfer (CRET)-mediated photodynamic therapy of cancer. However, the short duration signal and low quantum yield photosensitizer have limited its translational applications. Here, we report CRET-based nanoparticles (CRET-NPs) to achieve yield-enhanced cancer phototheranostics by reinterpreting hidden nature CRET. Owing reactive oxygen species (ROS)-responsive CO2 generation, CRET-NPs were capable generating a...
Mesoporous silica nanoparticles (MSNs) with stimuli-responsive gatekeepers have been extensively investigated for controlled drug delivery at the target sites.
Abstract Photoacoustic imaging (PAI), a state‐of‐the‐art noninvasive in vivo technique, has been widely used clinical disease diagnosis. However, the design of high‐performance PAI agents with three key characteristics, i.e., near‐infrared (NIR) absorption (λ abs >800 nm), intense PA signals, and excellent photostability, remains challenging goal. Herein, we present facile but effective approach for engineering by amplifying intramolecular low‐frequency vibrations enhancing push‐pull...
Sonodynamic therapy has received increasing attention for cancer treatments as an alternative to photodynamic therapy. However, its clinical applications have been limited by the lack of a sonosensitizer that is capable producing sufficient amounts reactive oxygen species (ROS) in response ultrasound (US) exposure. Herein, PEGylated mesoporous silica-titania nanoparticles (P-MSTNs) are prepared and used US-responsive nanocarriers sonotheranostics. Perfluorohexane (PFH), which chosen gas...
Background: Despite remarkable advances in sonodynamic therapy (SDT) of cancer, the low reactive oxygen species (ROS) quantum yield sonosensitizer remains a critical concern glutathione (GSH)-overexpressing cancer cells.Methods: For enhanced SDT, we report hydrophilized self-immolative polymer (SIP)-decorated TiO2 nanoparticles (HSIPT-NPs) to achieve on-demand GSH depletion and ROS generation.Results: Upon intracellular delivery HSIPT-NPs into hydrogen peroxide-rich cells, SIP is degraded...
Of the existing immunotherapy drugs in oncology, monoclonal antibodies targeting immune checkpoint axis are preferred because of durable responses observed selected patients. However, associated immune-related adverse events (irAEs), causing uncommon fatal events, often require specialized management and medication discontinuation. The study aim was to investigate our hypothesis that masking with tumor microenvironment (TME)-responsive polymer chains can mitigate irAEs selectively target...
Pumpkin (Cucurbita moschata Duchesne ex Poir.) is a multipurpose cash crop rich in antioxidants, minerals, and vitamins; the seeds are also good source of quality oils. However, pumpkin susceptible to fungus Podosphaera xanthii, an obligate biotrophic pathogen, which usually causes powdery mildew (PM) on both sides leaves reduces photosynthesis. The fruits infected plants often smaller than usual unpalatable. This study identified novel gene that involves PM resistance pumpkins through...
Self-assembled monolayers (SAMs), a molecular-level assembly that forms spontaneously, provide vehicle for investigating specific interactions at interfaces. This is particularly true mixed SAMs are composed of organosilanes with different chain lengths and/or chemical functionalities because they offer an adjustable surface constructing 3D structures containing variety moieties. We recently observed coadsorbed on Si wafer were separated into several tens or hundreds nanometer domains rich...
A highly specific interaction between a metal-deficient metalloenzyme and metal ion has been utilized in the selective detection of by surface plasmon resonance spectroscopy (SPRS). The use SPRS Cu-demetallated superoxide dismutase (E,Zn-SOD1) as sensing actuator allows one to selectively situ detect Cu2+ without any interference that other spectroscopic methods may have.
Arrhythmias after an esophagectomy (most commonly atrial fibrillation) are a significant contributing factor to patient morbidity. However, the significance of intraoperative arrhythmia is not completely understood. The aim this retrospective study was determine occurrence and risk factors for developing arrhythmias in patients undergoing esophagectomy.We reviewed records 427 who underwent transthoracic between 2001 2005. Variables such as age, sex, hypertension, diabetes, cardiac disease,...
Abstract Photoacoustic imaging (PAI), a state‐of‐the‐art noninvasive in vivo technique, has been widely used clinical disease diagnosis. However, the design of high‐performance PAI agents with three key characteristics, i.e., near‐infrared (NIR) absorption (λ abs >800 nm), intense PA signals, and excellent photostability, remains challenging goal. Herein, we present facile but effective approach for engineering by amplifying intramolecular low‐frequency vibrations enhancing push‐pull...
We succeeded in extending local oxidation to situ negative patterning. HF/EtOH was used as both gap-bridging electrolyte and oxyanion source. EtOH HF were found be able accelerate the growth of silicon oxide simultaneously etch grown oxide, respectively. These findings are expected open new possibilities utilizing nanolithography order directly fabricate deeper well structures while at same time maintaining lateral sizes within nanometer range.