A5101595820- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Neurological Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Bioinformatics and Genomic Networks
- Prion Diseases and Protein Misfolding
- Neuroscience and Neuropharmacology Research
- Urinary Bladder and Prostate Research
- Genetic Associations and Epidemiology
- Cerebrospinal fluid and hydrocephalus
- Biological Research and Disease Studies
- Health and Wellbeing Research
- Sexual function and dysfunction studies
- Skin Protection and Aging
- Urological Disorders and Treatments
- Epilepsy research and treatment
- Intensive Care Unit Cognitive Disorders
- Prostate Cancer Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Pelvic floor disorders treatments
- Folate and B Vitamins Research
- Brain Tumor Detection and Classification
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neurobiology of Language and Bilingualism
Seoul National University Bundang Hospital
2016-2025
Seoul National University
2014-2024
Indiana University – Purdue University Indianapolis
2019-2023
National University College
2020-2023
Indiana University School of Medicine
2019-2023
Hallym University
2023
Chuncheon Sacred Heart Hospital
2023
Indiana University
2023
New Generation University College
2022-2023
King's College London
2020
Abstract INTRODUCTION The molecular mechanisms underlying early‐onset Alzheimer's disease (EOAD) and late‐onset (LOAD) remain incompletely understood, particularly in Asian populations. METHODS RNA‐sequencing was carried out on blood samples from 248 participants the Seoul National University Bundang Hospital cohort to perform differential gene expression (DGE) weighted co‐expression network analysis. Findings were replicated an independent Korean ( N = 275). RESULTS DGE analysis identified...
Soluble amyloid-β (Aβ) oligomers are the major toxic substances associated with pathology of Alzheimer's disease (AD). The ability to measure Aβ oligomer levels in blood would provide simple and minimally invasive tools for AD diagnostics. In present study, recently developed Multimer Detection System (MDS) AD, a new enzyme-linked immunosorbent assay measuring selectively, was used detect plasma patients healthy control individuals.Twenty-four 37 cognitively normal individuals underwent...
To examine the validity and reliability of MMSE-2 for assessing patients with mild cognitive impairment (MCI) Alzheimer's disease (AD) in a Korean population. Specifically, usefulness as screening measure detecting early change, which has not been detectable through MMSE, was examined.Two-hundred twenty-six MCI, 97 AD, 91 healthy older adults were recruited. All participants consented to examination MMSE-2, other detailed neuropsychological assessments.The performed well discriminating...
Abstract Background Alzheimer’s dementia (AD) pathogenesis involves complex mechanisms, including microRNA (miRNA) dysregulation. Integrative network and machine learning analysis of miRNA can provide insights into AD pathology prognostic/diagnostic biomarkers. Methods We performed co-expression to identify modules associated with AD, its neuropathology markers, cognition using brain tissue profiles from the Religious Orders Study Rush Memory Aging Project (ROS/MAP) ( N = 702) as a discovery...
A reliable blood-based assay is required to properly diagnose and monitor Alzheimer's disease (AD). Many attempts have been made develop such a diagnostic tool by measuring amyloid-β oligomers (AβOs) in the blood, but none successful terms of method reliability. We present multimer detection system (MDS), initially developed for prion detect AβOs.To characterize Aβ plasma was spiked with synthetic (Aβ) incubated over time. Then, MDS used dynamic changes AβO levels plasma.Increasing...
Oligomeric amyloid-ß is a major toxic species associated with Alzheimer's disease pathogenesis. Methods used to measure oligomeric amyloid-β in the blood have increased number recent years. The Multimer Detection System-Oligomeric Amyloid-β (MDS-OAβ) specific method oligomerization tendencies blood. objective of this study was determine association between plasma and structural changes brain.We studied 162 subjects composed 92 community-based normal healthy subjects, 17 subjective cognitive...
Abstract INTRODUCTION Alzheimer's disease (AD) involves the complement cascade, with component 3 (C3) playing a key role. However, relationship between C3 and amyloid beta (Aβ) in blood is limited. METHODS Plasma Aβ oligomerization tendency (AβOt) were measured 35 AD patients 62 healthy controls. Correlations cerebrospinal fluid (CSF) biomarkers, cognitive impairment, positron emission tomography (PET) analyzed. Differences biomarkers compared groups classified by concordances of biomarkers....
Oligomeric amyloid-β (Aβ) is one of the major contributors to pathomechanism Alzheimer's disease (AD); Aβ oligomerization in plasma can be measured using a Multimer Detection System-Oligomeric (MDS-OAβ) after incubation with spiked synthetic Aβ.We evaluated clinical sensitivity and specificity MDS-OAβ values for prediction AD.The inBlood™ OAβ test heparin-treated samples from 52 AD patients comparison community-based subjects normal cognition (NC). The inclusion criterion was proposed by...
Abstract Background The Clock Drawing Test (CDT) and Rey–Osterrieth Complex Figure (RCFT) are widely used as a part of neuropsychological test batteries to assess cognitive function. Our objective was confirm the prediction accuracies RCFT-copy CDT for impairment (CI) using convolutional neural network algorithms screening tool. Methods data were obtained from patients aged 60–80 years who had more than 6 education. In total, 747 980 figures utilized. Convolutional TensorFlow (ver. 2.3.0) on...
Dementia subtypes, including Alzheimer's dementia (AD), with Lewy bodies (DLB), and frontotemporal (FTD), pose diagnostic challenges. This review examines the effectiveness of
Dementia often accompanies behavioral and psychological symptoms of dementia (BPSD), including agitation, aggression, depression, psychosis, which impact patients' quality life caregiver burden. Effective management BPSD is essential to support patient well-being. This study presents evidence-based clinical practice guidelines for pharmacological treatments in dementia, focusing on antipsychotics, antidepressants, cognitive enhancers, other medications. guideline was developed by the Korean...
This clinical practice guideline provides evidence-based recommendations for treatment of dementia, focusing on cholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists Alzheimer's disease (AD) other types dementia. Using the Population, Intervention, Comparison, Outcomes (PICO) framework, we developed key questions conducted systematic literature reviews. A multidisciplinary panel experts, organized by Korean Dementia Association, evaluated randomized controlled trials...
The mini-mental state examination (MMSE) was adapted by individual countries according to their languages and cultures, though it has not been systematically compared. objective of this study compare the linguistic cultural variations MMSE used in various Asian countries. With this, we can analyze strengths weaknesses consider using a common version future international clinical studies Asia. We collected MMSEs 11 nations. After translating those into English, compared them understand...
Steroid-resistant nephrotic syndrome (SRNS) is one of the major causes end-stage renal disease (ESRD) in childhood and mostly associated with focal segmental glomerulosclerosis (FSGS). More than 50 monogenic SRNS or FSGS have been identified. Recently, mutation detection rate pediatric patients has reported to be approximately 30%. In this study, genotype-phenotype correlations a cohort 291 Korean SRNS/FSGS were analyzed. The overall was 43.6% (127 patients). WT1 most common causative gene...
<b><i>Background:</i></b> The pathophysiology of transient global amnesia (TGA) is not fully understood. This study was conducted to identify the cardiovascular risk factors TGA compared those ischemic attack (TIA) and normal controls, using a large number subjects. In addition comparison factors, an association between observed in current pathophysiological mechanism recently investigated speculated upon. <b><i>Materials Methods:</i></b> We...
Background: Depressive symptoms are prevalent in patients with mild cognitive impairment (MCI) and considered to be a risk factor for progression dementia. Objective: The purpose of this study was evaluate whether depressive MCI promote disease manner related amyloid status, determine the relationship between longitudinal cerebral structural changes. Methods: Baseline data 336 (75 depression 261 without) from Alzheimer's Disease Neuroimaging Initiative were analyzed. All participants...
We hypothesized that hippocampal-sparing radiotherapy via volumetric modulated arc therapy (VMAT) could preserve the neurocognitive function (NCF) of patients with primary brain tumors treated radiotherapy. reviewed data from who underwent VMAT between February 2014 and December 2015. The optimization criteria for contralateral hippocampus was a maximum dose (Dmax) less than 17 Gy. For NCF evaluations, Seoul Verbal Learning Test total recall, delayed recognition (SVLT-TR, DR, Recognition)...
The interaction between the brain and periphery might play a crucial role in development of Alzheimer's disease (AD).