A5022442614- Advanced Radiotherapy Techniques
- Endometrial and Cervical Cancer Treatments
- Head and Neck Cancer Studies
- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Colorectal and Anal Carcinomas
- Advanced X-ray and CT Imaging
- Brain Metastases and Treatment
- Management of metastatic bone disease
- Cervical Cancer and HPV Research
- Head and Neck Surgical Oncology
- Lymphoma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Gastric Cancer Management and Outcomes
- CNS Lymphoma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Ear and Head Tumors
- Cancer Diagnosis and Treatment
- Viral-associated cancers and disorders
- Meningioma and schwannoma management
- Lung Cancer Diagnosis and Treatment
Seoul National University Bundang Hospital
2016-2025
Seoul National University Hospital
2023
Seoul National University
2008-2022
New Generation University College
2013
Evaluating the expression of signaling molecule proteins from mitogen-activated protein kinase (MAPK) pathway and phosphatidylinositol-3-kinase (PI3K) in invasive breast cancers may identify prognostic marker(s) associated with early relapse.Immunohistochemical analyses phosphatase tensin homologue deleted on chromosome 10 (PTEN), PI3K-p110alpha, phospho-AKT, phospho-p70S6 kinase, phospho-S6 ribosomal protein, phospho-RAF, phospho-p44/42 MAPK, heat-shock 90 (HSP90) were performed tumor...
The purpose of this study is to evaluate objective cosmetic outcomes and factors related breast-conserving therapy (BCT) using the BCCT.core software. Fifty-one patients who received BCT with informed consent were evaluated Patients divided into two groups based on BCCT score: excellent or good (n=42) vs. fair poor (n=9). Analysis clinical was performed determine affecting outcomes. outcome measured software in 10% patients, 72%, 18%. None classified as outcome. Tumor characteristics,...
We hypothesized that hippocampal-sparing radiotherapy via volumetric modulated arc therapy (VMAT) could preserve the neurocognitive function (NCF) of patients with primary brain tumors treated radiotherapy. reviewed data from who underwent VMAT between February 2014 and December 2015. The optimization criteria for contralateral hippocampus was a maximum dose (Dmax) less than 17 Gy. For NCF evaluations, Seoul Verbal Learning Test total recall, delayed recognition (SVLT-TR, DR, Recognition)...
Bulky or multiple lymph node (LN) metastases are associated with poor prognosis in cervical cancer, and the size number of LN is not yet reflected staging system therapeutic strategy. Although effects surgical resection bulky LNs before standard treatment have been reported several retrospective studies, well-planned randomized clinical studies lacking. Therefore, aim Korean Gynecologic Oncology Group (KGOG) 1047/DEBULK trial to investigate whether debulking surgery prior concurrent...
Evidence has shown that multidisciplinary tumor board conferences (MTBCs) improve patient management for various cancer types. However, few retrospective studies have investigated MTBC efficacy patients with gynecologic cancers. Here, we prospectively aimed to evaluate how MTBCs influence in oncology. This prospective study included 85 consecutive cases were presented at oncology our tertiary university hospital between January 2015 and April 2016. The primary endpoint was treatment plan...
The purpose of this study is to compare the prognostic efficacy number and location positive lymph nodes (LN), LN ratio (LNR), log odds LNs (LODDs) in high-risk cervical cancer treated with radical surgery adjuvant treatment.Fifty patients who underwent hysterectomy pelvic node dissection followed by treatment were analyzed retrospectively. had International Federation Gynecology Obstetrics (FIGO) stage IA2-IIB. Upper defined as common iliac or higher LN, LNR harvested LNs. LODDs between...
Abstract Lessons Learned Induction chemotherapy with Genexol-PM and cisplatin demonstrated modest tumor response in locally advanced head neck squamous cell carcinoma. Considering favorable toxicity profiles promising survival data, further studies on this regimen are warranted patients Background is a polymeric micellar formulation of paclitaxel without Cremophor EL. We investigated the efficacy safety plus as induction (IC) carcinoma (LA-HNSCC). Methods Patients received (230 mg/m2) (60...
Purpose To find the applicability of adjuvant radiotherapy for extrahepatic bile duct cancer (EBDC), we analyzed pattern failure and evaluate prognostic factors locoregional after curative resection without treatment. Materials Methods In 97 patients with resected EBDC, location tumor was classified as proximal (n = 26) distal 71), using junction cystic common hepatic dividing point. Locoregional sites were categorized follows: hepatoduodenal ligament bed, celiac artery superior mesenteric...
We investigated the effect of chemoradiotherapy with PP2 and temozolomide (TMZ) on malignant glioma cells using clonogenic assays in vivo brain tumor model. The radiosensitivity U251 T98G was assays. expression E-cadherin, matrix metalloproteinases 2 (MMP2), Ephrin type-A receptor (EphA2), vascular endothelial growth factor (VEGF) measured by Western blotting an accumulation γH2AX foci 6 hours after radiotherapy treatment. migration, invasion, vasculogenic mimicry formation (VMF) evaluated....
Considering the distinctive biology of triple-negative breast cancer (TNBC), this study aimed to identify TNBC-specific prognostic factors and determine value Nottingham Prognostic Index (NPI) its variant indices. A total 233 patients with newly diagnosed stage I III TNBC from 2003 2012 were reviewed. We retrospectively analyzed patients' demographics, clinicopathologic parameters, treatment, survival outcomes. The NPI was calculated as follows: tumor size (cm)×0.2+node...
Abstract Background Pre-operative chemoradiotherapy (CRT) is the standard treatment in clinical stage T3/4 or node positive rectal cancer. However, there are no established biomarkers that can predict pathological response and outcome to CRT. Methods Immunohistochemical staining was performed tissue arrays constructed from core specimens taken before operative 112 patients who received 5-FU based pre-operative CRT surgery. Expression of Ki67, TS, BAX, EpCAM, p53, p21, EGFR, CD44, CD133,...
The purpose of this study is to investigate the feasibility using a flattening filter-free (FFF) beam with an endorectal balloon for stereotactic ablative body radiotherapy (SABR) clinically localized prostate cancer. We assessed plans SABR volumetric-modulated arc therapy (VMAT) that used filter (FF) and FFF compared verification results dosimetric quality assurance all pretreatment plans. A total 20 patients cancer were enrolled in study. VMAT two full arcs optimized Eclipse treatment...
Background The use of immediate breast reconstruction and adjuvant radiation therapy is increasing in cancer patients. This study aimed to analyze the aesthetic outcome changes flap volume patients with undergoing surgical site after autologous tissue reconstruction. Methods Immediate abdominal free following unilateral mastectomy was performed 42 patients; 21 received (study group) did not (control group). To compare volume, three-dimensional computed tomography (CT) before radiation. Also,...
To compare the dosimetric effects of Acuros XB (AXB) and Anisotropic Analytical Algorithm (AAA) on volumetric modulated arc therapy (VMAT) planning for postoperative prostate cancer patients irradiated using an endorectal balloon (ERB).We measured central axis doses with film in a phantom containing air cavity, compared measurements calculations AAA AXB. For clinical study, 10 who had undergone whole pelvic radiotherapy (WPRT) followed by prostatic bed-only (PBRT) VMAT were enrolled. An ERB...
Purpose We aimed to refine the radiotherapy (RT) volume and dose for intracranial germinoma considering recurrences long-term toxicities.Materials Methods Total 189 patients with were treated RT alone (n=50) upfront chemotherapy (CRT) (n=139). All cases confirmed histologically. fields comprised extended-field involved-field only primary site. The extended-field, including craniospinal, whole brain (WB), ventricle (WV) cranial field, is followed by boost. median follow-up duration was 115...