A5101880791- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Microbial Metabolism and Applications
- Mast cells and histamine
- Developmental Biology and Gene Regulation
- Cancer Immunotherapy and Biomarkers
- Birth, Development, and Health
- Sodium Intake and Health
- Anesthesia and Sedative Agents
- Olfactory and Sensory Function Studies
- Menstrual Health and Disorders
- Cervical Cancer and HPV Research
- Nutritional Studies and Diet
- Epilepsy research and treatment
- Metabolomics and Mass Spectrometry Studies
- Lung Cancer Treatments and Mutations
- Endometriosis Research and Treatment
- Anesthesia and Neurotoxicity Research
- Infant Health and Development
The University of Texas at Austin
2024
Korea University
2013-2023
Seoul National University Bundang Hospital
2015
University of California, Los Angeles
2013
Kyung Hee University
2013
Neurobehavioral Systems
2013
Bucheon University
2012
In mammals, the increased secretion of arginine-vasopressin (AVP) (antidiuretic hormone) and oxytocin (natriuretic is a key physiological response to hyperosmotic stress. this study, we examined whether chronic stress weakens GABA(A) receptor-mediated synaptic inhibition in rat hypothalamic magnocellular neurosecretory cells (MNCs) secreting these hormones. Gramicidin-perforated recordings MNCs acute slices prepared from control rats ones subjected revealed that challenge not only attenuated...
Isolation stress is a major risk factor for neuropsychiatric disorders such as depressive and anxiety disorders. However, the molecular mechanisms underlying isolation-induced remain elusive. In present study, we investigated subcellular by which long-term isolation elicits depression anxiety-related behaviors in mice. First, found that induced depression-related forced swimming test (FST) sucrose preference test, well elevated zero maze (EZMT) open field test. Next, showed intra-central...
Increased arginine-vasopressin (AVP) secretion is a key physiological response to hyperosmotic stress and may be part of the mechanism by which high-salt diets induce or exacerbate hypertension.Using deoxycorticosterone acetate-salt hypertension model rats, we sought test hypothesis that changes in GABA(A) receptor-mediated inhibition AVP-secreting magnocellular neurons contribute generation Na(+)-dependent hypertension.In vitro gramicidin-perforated recordings paraventricular supraoptic...
Increased secretion of oxytocin and arginine vasopressin (AVP) from hypothalamic magnocellular neurosecretory cells (MNCs) is a key physiological response to lactation. In the current study, we sought test hypothesis that GABAA receptor-mediated inhibition MNCs altered in lactating rats. Gramicidin-perforated recordings rat supraoptic nucleus (SON) slices revealed reversal potential (EGABA) was significantly depolarized rats as compared virgin animals. The depolarizing EGABA shift much...
The purpose of this study is to compare the prognostic efficacy number and location positive lymph nodes (LN), LN ratio (LNR), log odds LNs (LODDs) in high-risk cervical cancer treated with radical surgery adjuvant treatment.Fifty patients who underwent hysterectomy pelvic node dissection followed by treatment were analyzed retrospectively. had International Federation Gynecology Obstetrics (FIGO) stage IA2-IIB. Upper defined as common iliac or higher LN, LNR harvested LNs. LODDs between...
Histamine, a neurotransmitter/neuromodulator implicated in the control of arousal state, exerts potent phase-shifting effect on circadian clock rodent suprachiasmatic nucleus (SCN). In this study, mechanisms by which histamine resets mouse SCN were investigated. As first step, Ca(2+) -imaging techniques used to demonstrate that increases intracellular concentration ([Ca(2+) ]i ) acutely dissociated neurons and increase is blocked H1 receptor (H1R) antagonist pyrilamine, removal extracellular...
Hyperexcitatory behaviors occurring after sevoflurane anesthesia are of serious clinical concern, but the underlying mechanism is unknown. These may result from potentiation by GABAergic depolarization/excitation in neocortical neurons, cells implicated genesis consciousness and arousal. The current study sought to provide evidence for this hypothesis with rats, neurons which known respond GABA (γ-aminobutyric acid) at early stages development (i.e., until second postnatal week)...
Recent evidence indicates that histamine, acting on histamine 1 receptor (H1R), resets the circadian clock in mouse suprachiasmatic nucleus (SCN) by increasing intracellular Ca(2+) concentration ([Ca(2+)]i) through activation of CaV1.3 L-type channels and Ca(2+)-induced release from ryanodine receptor-mediated internal stores. In current study, we explored underlying mechanisms with various techniques including Ca(2+)- Cl(-)-imaging extracellular single-unit recording. Our hypothesis was...
Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP), which may aggravate hyperglycemia and nephropathy. However, the mechanisms by DM cause AVP are not known. Electrophysiological recordings in supraoptic nucleus (SON) slices from streptozotocin (STZ)-induced rats vehicle-treated control revealed that γ-aminobutyric acid (GABA) functions generally as an excitatory neurotransmitter neurons STZ rats, whereas it usually evokes inhibitory responses...
Recent studies have provided several lines of evidence that peripheral administration oxytocin induces analgesia in human and rodents. However, the exact underlying mechanism still remains elusive. In present study, we aimed to identify which receptor could mediate analgesic effect intraperitoneal injection its cellular mechanisms thermal pain behavior. We found oxytocin-induced be reversed by d(CH2)5[Tyr(Me)2,Dab5] AVP, a vasopressin-1a (V1a) antagonist, but not desGly-NH2-d(CH2)5[DTyr2,...
Purpose: We aimed to establish an efficient method for retinal ganglion cell (RGC) differentiation from human pluripotent stem cells (hPSCs) using defined factors. Methods: To define the contribution of specific signal pathways RGC development and optimize hPSCs toward RGCs, we examined in three stages: (1) eye field progenitors expressing transcription factors (EFTFs), (2) MATH5, (3) RGCs BRN3B ISLET1. By monitoring condition that elicited highest yield stage-specific markers, determined...
Abundant evidence indicates that oestrogen (E2) plays a protective role against hypertension. Yet, the mechanism underlying antihypertensive effect of E2 is poorly understood. In this study, we sought to determine through which inhibits salt-dependent
In the present study, nutritional quality of four grains including adlay (AD), buckwheat (BW), glutinous barley (GB), and white rice (WR) were evaluated in terms plasma lipid parameters, gut transit time, thickness aortic wall rats. The rats then raised for 4 weeks on high-fat diet based American Institute Nutrition-93 (AIN-93 G) diets containing 1 % cholesterol 20 dietary lipids. Forty male divided into groups with a one following grains: WR, AD, BW, or WB. level thiobarbituric...
Objective: Estrogen has cardio-protective effect via several peripheral mechanism. But its action on central nervous system not been fully investigated. receptors are expressed in the hypothalamic magnocellular neurons, secreting vasopressin. In male-rat models of DOCA-salt, GABA functions as an excitatory, rather than inhibitory neurotransmitter vasopressin neurons. It might contribute to development and maintenance hypertension. current study, estrogen was investigated female rat models....
In mammals, photic information delivered to the suprachiasmatic nucleus (SCN) via retinohypothalamic tract (RHT) plays a crucial role in synchronizing master circadian clock located SCN solar cycle. It is well known that glutamate released from RHT terminals initiates process by activating ionotropic receptors (iGluRs) on retinorecipient neurons. The potential of metabotropic (mGluRs) modulating this signaling pathway has received less attention. study, using extracellular single-unit...