A5100677043- Genetics and Neurodevelopmental Disorders
- Advanced Memory and Neural Computing
- CRISPR and Genetic Engineering
- Genomics and Rare Diseases
- Ferroelectric and Negative Capacitance Devices
- Parkinson's Disease Mechanisms and Treatments
- Intelligent Tutoring Systems and Adaptive Learning
- Microbial Natural Products and Biosynthesis
- Neuroscience and Neuropharmacology Research
- Innovative Teaching and Learning Methods
- Alzheimer's disease research and treatments
- Epilepsy research and treatment
- Diet and metabolism studies
- Peroxisome Proliferator-Activated Receptors
- Genomic variations and chromosomal abnormalities
- Nuclear Receptors and Signaling
- Neural Networks and Applications
- Synthesis of Indole Derivatives
- Antimicrobial agents and applications
- Internet of Things and Social Network Interactions
- Organic Light-Emitting Diodes Research
- Extracellular vesicles in disease
- Neural Networks and Reservoir Computing
- Myofascial pain diagnosis and treatment
- Genetics, Aging, and Longevity in Model Organisms
Yonsei University
2017-2025
Severance Hospital
2020-2025
California University of Pennsylvania
2025
Korea Advanced Institute of Science and Technology
2021-2024
Samsung Medical Center
2024
Sungkyunkwan University
2022-2024
Konkuk University
2024
Dankook University
2023
Samsung (South Korea)
2022
Kyung Hee University
2022
Article4 September 2015Open Access Structure and function of the N-terminal domain human mitochondrial calcium uniporter Youngjin Lee School Life Sciences, Gwangju Institute Science Technology (GIST), Gwangju, Korea Steitz Center for Structural Biology, Search more papers by this author Choon Kee Min Systems Biology Research Center, Tae Gyun Kim Hong Ki Song Yunki Lim Dongwook Kahee Shin Moonkyung Kang Graduate New Drug Discovery & Development, Chungnam National University, Daejon, Jung Youn...
We intended to evaluate diagnostic utility of a targeted gene sequencing by using next generation (NGS) panel in patients with intractable early-onset epilepsy (EOE) and find the efficient analytical step for increasing diagnosis rate. assessed 74 EOE whose seizures started before 3 years age customized NGS that included 172 genes. Single nucleotide variants (SNVs) exonic chromosomal copy number variations (CNVs) were intensively examined our pipeline crosschecked commercial or pre-built...
The thin-film growth conditions in a plasma-enhanced atomic layer deposition for the (3.0–4.5) nm thick HfO2 film were optimized to use as resistive switching element neuromorphic circuit. was intended be used feasible synapse with analog-type conductance-tuning capability. 4.5 films on both conventional TiN and new RuO2 bottom electrode required electroforming process them operate memory, which primary source of undesirable characteristics synapse. Therefore, electroforming-free performance...
Diseases vary in clinical presentation across individuals despite the same molecular diagnosis. In fragile X syndrome (FXS), mutation-length expansion of a CGG short tandem repeat (STR) FMR1 causes reduced gene expression and FMRP loss. Nevertheless, are limited predictors adaptive functioning cognition FXS patients, suggesting that correlates measures would add diagnostic value. We recently uncovered Megabase-scale domains heterochromatin (BREACHes) patient-derived iPSCs. Here, we identify...
The integration of membrane proteins into "lipid raft" domains influences many biochemical processes. intrinsic structural properties are thought to mediate their partitioning between domains. However, whether topology the targeting rafts remains unclear. To address this question, we examined domain preference three putative raft-associated with widely different topologies: human caveolin-3, C99 (the 99 residue C-terminal amyloid precursor protein), and peripheral myelin protein 22. We find...
In electronic bipolar resistive switching (eBRS), the electron trapping and detrapping at defect sites within layer, such as highly defective TiO1.7 in this study, constitute mechanism. It is an appealing candidate solution to nonuniformity issue of memory. However, TiO1.7-based eBRS has suffered from a lack endurance retention. 7 nm-thick stoichiometric TiO2 layer interposed between Al bottom electrode 50 which contact with top electrode. Despite minimal structural modification,...
Brain aging is a complex biological process that affected by both genetic background and environment. The transcriptomic analysis of aged human rodent brains has been applied to identify age-associated molecular cellular processes for which intervention could possibly restore declining brain functions induced aging. However, whether these alterations are indeed involved in the healthy remains unclear. We herein characterized naturally occurring, extremely long-lived (34 months age) but mouse...
Pathological protein inclusion formation and propagation are the main causes of neuronal dysfunction in diverse neurodegenerative diseases; therefore, current disease-modifying therapeutic strategies have targeted this disease aggregation process. Recently, we reported that peucedanocoumarin III (PCiii) is a promising compound with ability to disaggregate α-synuclein protect dopaminergic neurons Parkinson’s (PD). Here, found trans-4′-acetyl-3′-tigloylkhellactone (racemic IV [PCiv]),...
Abstract Mammalian genomes are folded into tens of thousands long-range looping interactions 1,2 . The cause and effect relationship between genome function is poorly understood, the extent to which chromatin loops dynamic on short time scales remains a fundamental unanswered question. Currently available strategies for loop engineering involve synthetic transcription factors tethered dCas9 3,4 or zinc fingers 5,6 , constitutively expressed induced long by presence small molecule 3 Here we...
In spite of remarkable progress in machine learning techniques, the state-of-the-art algorithms often keep machines from real-time (online learning) due, part, to computational complexity parameter optimization. As an alternative, a algorithm train memory real time is proposed, named Markov chain Hebbian algorithm. The pursues efficient use during training that: 1) weight matrix has ternary elements (-1, 0, and 2) each update follows chain-the upcoming does not need past values. was verified...