A5057714776- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Genomics and Rare Diseases
- Epigenetics and DNA Methylation
- Genomic variations and chromosomal abnormalities
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Genetics and Neurodevelopmental Disorders
- Ovarian cancer diagnosis and treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Protein Degradation and Inhibitors
- CNS Lymphoma Diagnosis and Treatment
- CRISPR and Genetic Engineering
- PARP inhibition in cancer therapy
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Concrete and Cement Materials Research
- RNA modifications and cancer
- Multiple Myeloma Research and Treatments
- Innovative concrete reinforcement materials
Yonsei University
2016-2025
University of Maryland, Baltimore
2017-2025
Severance Hospital
2016-2025
University of Maryland Medical Center
2019-2025
Yonsei University Health System
2019-2025
Kangwon National University
2022-2025
University Health System
2025
U-M Rogel Cancer Center
2017-2024
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2018-2024
National Center for Advancing Translational Sciences
2024
The identification of oncogenic mutations in diffuse large B-cell lymphoma (DLBCL) has led to the development drugs that target essential survival pathways, but whether targeting multiple pathways may be curative DLBCL is unknown.
For cultured meat to effectively replace traditional meat, it is essential develop scaffolds that replicate key attributes of real such as taste, nutrition, flavor, and texture. However, one the significant challenges in replicating characteristics with lies considerable gap between stiffness preferred by cells textural properties desired humans. To address this issue, we focused on microscale environment conducive cell growth macro-scale favored This led development adaptive...
Summary. A 20‐year‐old woman with high‐risk acute myelogenous leukaemia was transplanted granulocyte colony stimulating factor (G‐CSF)‐mobilized peripheral blood CD34 + haematopoietic stem cells and bone‐marrow‐derived mesenchymal (MSC) from her human leucocyte antigen haplotype‐mismatched father after myeloablative conditioning therapy. The patient engrafted rapidly had no or chronic graft‐versus‐host disease. Since transplantation, the has shown an enduring trilineage haematological...
The epigenetic changes during B-cell development relevant to both normal function and hematologic malignancy are incompletely understood. We examined DNA methylation RNA expression status early by sorting multiple replicates of four separate stages pre-B cells derived from human fetal bone marrow applied high-dimension scanning arrays. Features promoter gene body were strongly correlated with in multipotent progenitors (MPPs) a static state throughout differentiation. As MPPs commit cells,...
Abstract Context: Detection of the BRAF V600E mutation in fine-needle aspiration cytology (FNAC) specimens may increase value FNAC. Objective: The objectives study was to compare diagnostic performance assays that differ sensitivity and examine associations between status clinicopathological features papillary thyroid carcinoma (PTC). Design Setting: Three molecular were performed all subjects compared with regard FNAC histology results. Participants: We evaluated 4585 consecutive patients...
The Sysmex XN-series is a new automated hematology analyzer designed to improve the accuracy of cell counts and specificity flagging events.The basic characteristics performance measurement channels XN were evaluated compared with XE-2100 manual method. Fluorescent platelet count (PLT-F) was flow cytometric low WBC mode body fluid also evaluated. For workflow analysis, 1005 samples analyzed on both XE-2100, review rates compared.All parameters measured by correlated well XE-2100. PLT-F...
Objectives: Pathogenic mutations in developmental and epileptic encephalopathy (DEE) are increasingly being discovered. However, little has been known about effective targeted treatments for this rare disorder. Here, we assessed the efficacy of ketogenic diet (KD) according to genes responsible DEE. Methods: We retrospectively evaluated data from 333 patients who underwent a next-generation sequencing panel DEE, 155 whom had tried KD. Patients showing ≥90% seizure reduction baseline were...
We intended to evaluate diagnostic utility of a targeted gene sequencing by using next generation (NGS) panel in patients with intractable early-onset epilepsy (EOE) and find the efficient analytical step for increasing diagnosis rate. assessed 74 EOE whose seizures started before 3 years age customized NGS that included 172 genes. Single nucleotide variants (SNVs) exonic chromosomal copy number variations (CNVs) were intensively examined our pipeline crosschecked commercial or pre-built...
Given that mycosis fungoides-cutaneous T-cell lymphoma (MF/CTCL) is chronic, there a need for additional therapies with minimal short- and long-term adverse effects. Topical synthetic hypericin ointment, 0.25%, activated visible light novel, nonmutagenic photodynamic therapy (PDT).To determine the efficacy safety of topical as PDT in early-stage MF/CTCL.This was multicenter, placebo-controlled, double-blinded, phase 3 randomized clinical trial (FLASH study) conducted from December 2015 to...
Abstract Human epidermal growth factor receptor-2 (HER2)-targeting drugs are increasingly being incorporated into therapeutic paradigms for non-breast cancers, yet studies on HER2 expression in ovarian cancer (OC) inadequate. Here, we studied the status and dynamic changes OC by reviewing records of patients who underwent testing at a single institution. Clinical parameters, including histology, BRCA status, immunohistochemistry (IHC), were evaluated alongside expression, timing, anatomical...
Abstract Introduction Acute myeloid leukemia (AML) is a complex hematologic malignancy characterized by uncontrolled proliferation of precursor cells within bone marrow. Despite advances in understanding its molecular underpinnings, AML remains therapeutic challenge due to high relapse rate and clonal evolution. Methods In this retrospective study, we analyzed data from 24 patients diagnosed at single institution between January 2017 August 2023. Comprehensive genetic analyses, including...
The mechanism and medical treatment target for degenerative aortic valve disease, including stenosis, is not well studied. In this study, we investigated the effect of clonal hematopoiesis indeterminate potential (CHIP) on development sclerosis (AVS), a calcified without significant stenosis.
Abstract Cyclin-dependent kinase inhibitor p27Kip1 functions at the nuclear level by binding to cyclin E/cyclin-dependent kinase-2. It was shown that Akt or protein B (Akt/PKB)-dependent phosphorylation of led cytoplasmic mislocalization p27Kip1, suggesting potential abrogation its activity. Here, we evaluated localization in leukemic blasts relation Akt/PKB and clinical outcomes acute myelogenous leukemia (AML). Western blot analysis fractions revealed a heterogenous pattern AML....
Abstract Oxidative stress is an imbalance between free radicals and antioxidant molecules that can play important role in the pathogenesis of iron‐deficiency anemia (IDA). The aim this study was to investigate oxidative status patients with IDA alteration after iron treatment. Thirty‐three female 25 healthy controls were included study. Oxidant total capacity determined using oxygen test defence (Form CR 3000, Callegari, Parma, Italy). Catalase activity measured by spectrophotometer a...
Pharmacogenetic studies on clozapine (CLZ) have provided meaningful insights but shown redundancies owing to wide interindividual variability and insufficient replication. The present study was designed validate hitherto suggested candidate genes CLZ pharmacokinetics pharmacodynamics explore new markers through an integrative study.Based a literature review, total of 127 variations in 27 were selected analyzed. Ninety-six schizophrenic patients Korean ethnicity with constant dosing...
Infantile nystagmus syndrome (INS) is a group of disorders presenting with genetic and clinical heterogeneities that have challenged the diagnoses INS. Precise molecular diagnosis in early infancy may result more accurate counseling improved patient management.
Clozapine clearance is influenced by sex, smoking status, ethnicity, coprescription of inducers or inhibitors, obesity, and inflammation. In 126 Beijing inpatients, we measured repeated trough steady-state serum concentrations identified 4% (5/126) who were phenotypical poor metabolizers (PMs); none ultrarapid (UMs). They defined as being 2 SDs beyond the means total clozapine concentration/dose ratios stratified sex smoking. Using this definition, study explores prevalence PMs UMs using...
Abstract Purpose: Patient-specific molecular alterations leading to PARP inhibitor (PARPi) resistance are relatively unexplored. In this study, we analyzed serially collected circulating tumor DNA (ctDNA) from patients with BRCA1/2 mutations who received PARPis investigate the mechanisms and their significance in postprogression treatment response survival. Experimental Design: Patients were prospectively enrolled between January 2018 December 2021 (NCT05458973). Whole-blood samples obtained...
Abstract Circulating tumor DNA (ctDNA) may aid in personalizing ovarian cancer therapeutic options. Here, we aimed to assess the clinical utility of serial ctDNA testing using tumor-naïve, small-sized next-generation sequencing (NGS) panels. A total 296 patients, including 201 with and 95 benign or borderline disease, were enrolled. Samples collected at baseline (initial diagnosis surgery) every 3 months after that, resulting a 811 blood samples. Patients received adjuvant therapy based on...