A5020423857- Cardiac electrophysiology and arrhythmias
- Extracellular vesicles in disease
- Cardiomyopathy and Myosin Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ion channel regulation and function
- Cardiac pacing and defibrillation studies
- Textile materials and evaluations
- Diabetes Management and Education
- Photonic and Optical Devices
- Semiconductor Lasers and Optical Devices
- Metabolism, Diabetes, and Cancer
- Stress Responses and Cortisol
- Atrial Fibrillation Management and Outcomes
- Material Properties and Processing
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Disease and Adiposity
- Material Properties and Applications
- Circular RNAs in diseases
- Cardiovascular Effects of Exercise
- Liver Disease Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- MicroRNA in disease regulation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Ion Transport and Channel Regulation
- Ocular and Laser Science Research
University of Ulsan
2020-2021
Ulsan College
2020-2021
Gangnam Severance Hospital
2018
Yonsei University
2015-2018
Korea University
2018
Isolation stress is a major risk factor for neuropsychiatric disorders such as depressive and anxiety disorders. However, the molecular mechanisms underlying isolation-induced remain elusive. In present study, we investigated subcellular by which long-term isolation elicits depression anxiety-related behaviors in mice. First, found that induced depression-related forced swimming test (FST) sucrose preference test, well elevated zero maze (EZMT) open field test. Next, showed intra-central...
Purpose: Bioactive molecules critical to intracellular signaling are contained in extracellular vesicles (EVs) and have cardioprotective effects ischemia/reperfusion (IR) injured hearts.This study investigated the mechanism of EVs derived from hypoxia-preconditioned human mesenchymal stem cells (MSCs).Materials Methods: EV solutions (0.4 μg/μL) normoxia-preconditioned MSCs (EVNM) (EVHM) were delivered a rat IR injury model.Successful delivery was confirmed by detection PKH26 staining hearts...
Background:The serotonin receptor type 3 (Htr3) blocker is associated with QT prolongation and torsades de pointes. However, little known about effects of Htr3 on the heart arrhythmia.Methods Results:An electrophysiological study Involving knock-out (KO) female mice lacking functional Htr3a (Htr3a–/–) their wild-type littermates during non-pregancy (NP) late pregnancy (LP) was performed. mRNA present in wild-type, but not theHtr3a–/–mouse hearts. Serotonin tryptophan hydroxylase 1 (Tph1), a...
The mechanisms underlying repolarization abnormalities during pregnancy are not fully understood. Although maternal serotonin (5-hydroxytryptamine, 5-HT) production is an important determinant for normal fetal development in mice, its role mothers remains unclear. We evaluated the of ventricular mice hearts via 5Htr3 receptor (Htr3a) and investigated mechanism QT-prolongation pregnancy. measured current amplitudes expression levels voltage-gated K⁺ (Kv) channels freshly-isolated left...
Background: Elevated maternal serotonin (5-hydroxytryptamine, 5-HT) production is an important determinant of normal fetal development. However, what roles the elevated plays in electrophysiology mother’s heart has not been studied. In present study, we therefore assessed relationship between QTc duration and studied underlying mechanisms. Methods results: During pregnancy, 5-HT tryptophan hydroxylase 1, a rate-limiting enzyme synthesis, were markedly increased hearts serum. We measured QT...
Background The Htr3a antagonist, ondansetron, has been reported to prolong the QT interval and induce Torsades de pointes in treatment of postoperative nausea vomiting. To explore mechanisms underlying these findings, we examined effects ondansetron on mouse cardiac voltage-gated K+ (Kv) channel. Methods Results Ondansetron increased intervals late pregnant (LP) mice. We measured Kv channels freshly isolated left ventricular (LV) myocytes from non-pregnant (NP) mice, using patch-clamp...
Background: To investigate the association of mean plasma glucose (PG) concentration measured at 0, 60, and 120 min (GLUM0·60·120) during an oral tolerance test (OGTT) risk type 2 diabetes (T2DM), to compare its predictability with that other OGTT-based PG values.Methods: We examined data 7533 T2DM-free participants acquired from Korean Genome Epidemiology Study. Adjusted hazard ratios (HR) for 12-year follow-up incidence T2DM were estimated by a Cox proportional model according...