A5101722610- Acute Myeloid Leukemia Research
- Bacterial Identification and Susceptibility Testing
- Respiratory viral infections research
- Clinical Laboratory Practices and Quality Control
- Alzheimer's disease research and treatments
- Antifungal resistance and susceptibility
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Infections and bacterial resistance
- Fungal Infections and Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Hematological disorders and diagnostics
- Hemodynamic Monitoring and Therapy
- Pneumocystis jirovecii pneumonia detection and treatment
- Meta-analysis and systematic reviews
- Pneumonia and Respiratory Infections
- Chronic Myeloid Leukemia Treatments
- Influenza Virus Research Studies
- Mycobacterium research and diagnosis
- Genomics and Phylogenetic Studies
- Viral gastroenteritis research and epidemiology
- Oral microbiology and periodontitis research
- Iron Metabolism and Disorders
- Cancer Genomics and Diagnostics
Chung-Ang University
2015-2024
Chung-Ang University Hospital
2015-2024
Seoul National University Hospital
2021-2023
Ewha Womans University
2021
Luigi Sacco Hospital
2021
University of Milan
2021
The University of Texas MD Anderson Cancer Center
2014-2017
Korea Institute of Radiological and Medical Sciences
2017
Korea Air Force Academy
2017
Oligomeric amyloid-β (Aβ) is one of the major contributors to pathomechanism Alzheimer's disease (AD); Aβ oligomerization in plasma can be measured using a Multimer Detection System-Oligomeric (MDS-OAβ) after incubation with spiked synthetic Aβ.We evaluated clinical sensitivity and specificity MDS-OAβ values for prediction AD.The inBlood™ OAβ test heparin-treated samples from 52 AD patients comparison community-based subjects normal cognition (NC). The inclusion criterion was proposed by...
Abstract Corona virus disease 2019 (COVID-19) has been declared a global pandemic and is major public health concern worldwide. In this study, we aimed to determine the role of environmental factors, such as climate air pollutants, in transmission COVID-19 Republic Korea. We collected epidemiological data from two regions Korea, namely Seoul metropolitan region (SMR) Daegu-Gyeongbuk (DGR) February 2020 July 2020. The was then analyzed identify correlations between each factor with confirmed...
Seroprevalence of the IgG antibodies for Clonorchis sinensis, Paragonimus westermani, Taenia solium metacestode (cysticercus), and Spirometra erinacei plerocercoid (sparganum) was measured using enzyme-linked immunosorbent assay (ELISA) in sera patients Korea from 1993 to 2006. A total 74,448 specimens referred nationwide 121 hospitals revealed an positive rate 7.6% 4 parasites. The (18.7%) parasites decreased gradually 6.6% Individual 5.2% (1993) 1.6% (2006) C. 2.8% 1.1% P. 8.3% 2.2%...
Abstract Our previous study has shown that an extremely low‐frequency magnetic field (ELF‐MF) induces nitric oxide (NO) synthesis by Ca 2+ ‐dependent NO synthase (NOS) in rat brain. The present was designed to confirm ELF‐MF affects neuronal NOS (nNOS) several brain regions and investigate the correlation between nNOS activation. exposure of rats a 2 mT, 60 Hz for 5 days resulted increases levels parallel with cGMP elevations cerebral cortex, striatum, hippocampus. Cresyl violet staining...
We evaluated the diagnostic accuracy of two newly developed, point-of-care, rapid antigen tests (RATs) for detecting SARS-CoV-2, AFIAS COVID-19 Ag and ichroma TM Ag, investigated kinetics. A total 200 serially collected nasopharyngeal (NP) specimens from 38 patients 122 negative controls were analyzed. Diagnostic sensitivity specificity assessed in comparison to molecular test results subdivided according targeted genes ( E , RdRP N ) days post-symptom onset (PSO). For kinetics evaluation,...
Background The Sysmex DI-60 digital morphology analyzer is a fully automated, cell-locating image analysis system. This study aimed to evaluate the analytical performance of DI-60. Methods A total 822 peripheral blood smears were used. diagnostic in terms red cell (RBC) characterization, white (WBC) differentials, and assay time including hands-on was evaluated. Results In comparison with manual slide review, demonstrated acceptable accuracy recognizing polychromasia, target cells,...
Background: Elevated metabolic activity of amygdala is known to be related atherosclerotic cardiovascular event by increasing inflammatory cell production from bone marrow. We tried identify the factors in amygdala, vertebrae, liver, spleen, and internal carotid artery future vascular events after stroke. Methods: A total 110 patients with acute stroke were included (72±10 years age, 39% women) underwent whole-body 18 F-fluorodeoxyglucose (FDG) positron emission tomography between August 1,...
Summary Introduction We evaluated the prevalence and severity of asymptomatic neutropenia in a healthy Korean population according to sex age. explored normal neutrophil‐to‐lymphocyte ratio ( NLR ) platelet‐to‐lymphocyte PLR an association these ratios with biomarkers related inflammation, rheumatoid disease, glucose metabolism. Methods analyzed complete blood cell counts 83 740 subjects who participated routine health check‐up program. were compared age, factor, C‐reactive protein CRP ),...
Abstract Background Human metapneumovirus (hMPV) commonly causes upper and lower respiratory tract infections. Here, we performed long-term retrospective surveillance of hMPV infection among patients hospitalized in South Korea between 2007 2016 investigated seasonal dynamics clinical characteristics associated with each virus subtype/genotype. Methods Patient specimens were tested for other viruses by commercial molecular assays. Medical records hMPV-positive reviewed, subtype/genotype...
Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker in the detection of kidney injury. Early diagnosis urinary tract infection (UTI), one most common infections children, important order to avert long-term consequences. We assessed whether serum NGAL (sNGAL) or urine (uNGAL) would be reliable markers UTI and evaluated appropriate diagnostic cutoff value for screening children.A total 812 specimens 323 samples, collected from pediatric patients, were analyzed. was...
Background Coronavirus disease 2019 (COVID-19) is an emerging threat worldwide. This study aims to assess the serologic profiles and time kinetics of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with COVID-19 using two immunoassays. Methods A total 97 samples serially collected from 17 137 negative control were analyzed for IgM IgG SARS-CoV-2 AFIAS Ab (Boditech Med Inc., Chuncheon, Republic Korea) EDI™ Novel ELISA Kit (Epitope Diagnostics, San...
To test the hypothesis that bone mineral loss is mechanistically related to cerebral small vessel disease (SVD), we investigated relationship between density and prevalence intensity of SVD among patients with stroke.We analyzed data 1,190 consecutive stroke who were >50 years age underwent both brain MRI dual-energy x-ray absorptiometry from registry Chung-Ang University Hospital in Seoul, Korea. The categorized into 3 groups according their (normal, osteopenia, osteoporosis). White matter...
<b><i>Background/Aim: </i></b>Our aim was to determine whether altered human β-defensin (HBD), pro-inflammatory cytokines including interleukin (IL)-6 and tumor necrotic factor (TNF)-α could increase the risk of developing exacerbation chronic kidney disease (CKD), especially for patients with diabetic nephropathy (DN). <b><i>Methods: </i></b>Serum samples were obtained from 338 CKD 88 sex, age-matched healthy controls. The concentrations HBD-1...
Because increasing numbers of nasopharyngeal swab specimens from adult patients with acute respiratory illness (ARI) are being tested by virus (RV) multiplex reverse transcriptase PCR (RVM-RT-PCR), multiple RV detection (MRVD) is encountered more frequently. However, the clinical relevance MRVD in has rarely been evaluated. The characteristics hospitalized ARI and RVM-RT-PCR tests were compared to those single (SRVD) during a year at tertiary care center. was observed 26 190 (13.7%). had...
High on-treatment platelet reactivity (HTPR) is the phenomenon wherein patients exhibit normal activity in laboratory testing despite adequate adherence to anti-platelet treatment. We investigated detection rates of Platelet Function Analyzer (PFA)-100 (Dade Behring AG, Düdingen, Switzerland) for drug-induced dysfunction and analyzed potential contributors HTPR with practical PFA-100 data over six years.We used from 6,957 who underwent after receiving aspirin, clopidogrel, or non-steroidal...
The laboratory diagnosis of latent tuberculosis infection (LTBI) is mainly performed with interferon gamma release assays (IGRAs). We compared the performance a new enzyme-linked immunosorbent assay (ELISA)-based IGRA, Standard E TB-Feron ELISA (TBF; SD Biosensor, Gyeonggi-do, Republic Korea), that widely used assay, QuantiFERON-TB Gold In-Tube (QFT-GIT; Qiagen, Hilden, Germany), in population 425 health care workers (HCWs).
Janibacter hoylei has previously been isolated only from an air sample in the upper atmosphere and clinical significance of J. was not yet established. Herein, we report a case bacteremia caused by . An 8‐week‐old healthy male infant presented to emergency room with fever. Blood culture yielded growth Gram‐positive bacilli this microorganism could be identified conventional phenotypic methods. The isolate 16S rRNA gene sequencing, patient successfully treated vancomycin. To our knowledge, is...
We report a case of Campylobacter volucris bacteremia in an immunocompromised patient with polycythemia vera and alcoholic liver cirrhosis. To our knowledge, this is the first which organism has been isolated from human clinical specimen.