A5070796076- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Respiratory viral infections research
- Antimicrobial Resistance in Staphylococcus
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Infective Endocarditis Diagnosis and Management
- Long-Term Effects of COVID-19
- Streptococcal Infections and Treatments
- Antifungal resistance and susceptibility
- Urinary Tract Infections Management
- Infection Control and Ventilation
- Antibiotic Use and Resistance
- SARS-CoV-2 detection and testing
- Fungal Infections and Studies
- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- COVID-19 and healthcare impacts
- Orthopedic Infections and Treatments
- Urinary Bladder and Prostate Research
- Heparin-Induced Thrombocytopenia and Thrombosis
Chung-Ang University Hospital
2014-2025
Chung-Ang University
2010-2022
Mayo Clinic
2014-2015
Kyung Hee University
2011
Asan Medical Center
2002-2008
University of Ulsan
2002-2008
Ulsan College
2003-2008
Ministry of Food and Drug Safety
2005
Gachon University Gil Medical Center
2003
Wonkwang University
1997
Duration of Positive SARS-CoV-2 on RT-PCR and Culture In 21 consecutive patients with confirmed Covid-19, the median times from symptom onset to negative viral culture real-time RT-PCR...
The severity of COVID-19 ranges from mild to critical diseases. However, limited data have been published on the detailed kinetics viral load and host immune response throughout disease course depending severity. In this study, we comprehensively analyzed load, antibody responses SARS-CoV-2, cytokines/chemokines during course, identified factors related Nasopharyngeal (NP) plasma specimens were obtained 31 patients with hospitalization. Viral RNA in NP was quantified by reverse...
Risk factors for the nosocomial occurrence of imipenem-resistant Acinetobacter baumannii (IRAB) were determined. A case-control study design was used a comparison two groups A. baumannii-positive patients with control patients. Nosocomial IRAB isolated from first group patients, and imipenem-susceptible (ISAB) second group. The randomly selected in 4:1 ratio same medical or surgical services which receiving care when isolation occurred. analyzed included demographic variables, comorbid...
The isolation of carbapenem-resistant Klebsiella pneumoniae (CRKP) has been increasingly reported. However, no study analyzing potential risk factors for the acquisition CRKP published as now. We therefore performed a case-control to determine CRKP. was nosocomially isolated from 30 patients between January 1997 and August 2003. Control were randomly selected at ratio 4:1 same medical or surgical services which receiving care when occurred. Risk previous use carbapenem (adjusted odds [AOR],...
Of 63 patients with Staphylococcus lugdunensis bacteremia, 15 (23.8%) had clinically significant an incidence of 1.3 cases per 100,000 admissions. the five community-acquired S. three endocarditis. Catheters were most common portal entry for health-care-associated or hospital-acquired bacteremia. Only one patient died bacteremia-related causes.
During the coronavirus disease (COVID-19) pandemic, social distancing was effective in controlling spread across South Korea. The impact of national on common respiratory virus infections has rarely been investigated. We evaluated weekly proportion negative polymerase chain reaction (PCR) test results and positive rates each during period (10th–41st weeks 2020) corresponding different years, utilizing surveillance dataset reported by Korean Center for Disease Control Prevention. proportions...
Background: Remdesivir is widely used for the treatment of coronavirus disease 2019 (COVID-19), but controversies regarding its efficacy still remain.Methods: A retrospective cohort study was conducted to evaluate effect remdesivir on clinical and virologic outcomes severe COVID-19 patients from June July 2020.Primary endpoints included recovery, additional mechanical ventilator (MV) support, duration oxygen or MV support.Viral load reduction by hospital day (HD) 15 evaluated calculating...
It remains unclear whether high titers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies aggravate clinical manifestations in patients or result antibody titers. Thus, we investigated the cause-effect relationship between SARS-CoV-2 and disease severity.We prospectively enrolled admitted with diagnosis disease-19 (COVID-19) from February 2020 to August 2020. We measured titers, namely anti-receptor-binding domain (RBD) neutralizing (NAb), blood samples calculated...
Background: This study investigated the humoral responses to SARS-CoV-2 in hemodialysis (HD) patients. The clearance of molecules blood during is influenced by factors such as filter pore size, flow rate, operating pressure, and treatment duration. Chronic kidney disease patients often show low antibody titers for pathogens like pneumococcus, influenza virus, hepatitis B virus. Methods: In this study, surrogate virus neutralization test (sVNT) wild type (WT) Omicron variants, well...
Abstract Spinal implant infection is a rare but significant complication of spinal fusion surgery, and the most common pathogen Staphylococcus aureus . It difficult to treat due this pathogen's biofilm-forming ability antibiotic resistance. We evaluated therapeutic outcome treatments for S infections. retrospectively reviewed all patients with infections at 11 tertiary-care hospitals over 9-year period. Parameters predictive treatment failure recurrence were analyzed by Cox regression. Of...
Objectives This study investigates whether COVID-19 vaccines can elicit cross-reactive antibody responses against the Omicron variant in patients with autoimmune rheumatic diseases (ARDs). Methods observational cohort comprised 149 ARDs and 94 healthcare workers (HCWs). Blood samples were obtained at enrolment, a median of 15 weeks after second vaccine dose or 8 third dose. The functional cross-neutralisation capacity sera was measured using receptor-binding domain-ACE2 binding inhibition...
Objectives Complicated intra-abdominal infection (cIAI) is that extends beyond the hollow viscus of origin into peritoneal space, and associated with either abscess formation or peritonitis. There are few studies have assessed actual costs outcomes failure initial antibiotic therapy for cIAI. The aims this study were to evaluate risk factors impact on community-onset Methods A retrospective was performed at eleven tertiary-care hospitals. Hospitalized adults cIAI who underwent an appropriate...
ObjectivesEarly in vitro studies have suggested that hydroxychloroquine (HCQ) is a potentially useful drug against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. This study was conducted to determine whether HCQ had preventive effect on disease 2019 (COVID-19) rheumatic patients who were taking HCQ.MethodsWe population-based retrospective cohort using the records of Korean Health Insurance Review and Assessment (HIRA) claim records. The clinical data with rheumatoid...
BACKGROUND: There is limited information describing the presenting characteristics and dynamic clinical changes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosed early phase of illness. This study a case series patients with disease 2019 (COVID-19) admitted to 11 hospitals Korea. METHODS: Patients confirmed SARS-CoV-2 by positive polymerase chain reaction (PCR) testing specimens active surveillance that were finally discharged between February 20 April 30,...
Data on the longevity of humoral and cell-mediated immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with disease 2019 (COVID-19) are limited. We evaluated detailed kinetics antibody T-cell at acute, convalescent, post-convalescent phases COVID-19 a wide range severity. enrolled prospectively from four hospitals one community treatment center between February 2020 January 2021. symptom severity was classified as mild, moderate, or...
We developed a new magnetic resonance indicator for necrotizing fasciitis (MRINEC) algorithm differentiating (NF) from severe cellulitis (SC). All adults with suspected NF between 2010 and 2018 in tertiary hospital South Korea were enrolled. Sixty-one patients diagnosed 28 SC. Among them, 34 15 SC underwent imaging (MRI). The MRINEC algorithm, two-step decision tree including T2 hyperintensity of intermuscular deep fascia diffuse peripheral fascia, 94% sensitivity (95% confidence interval...