A5041224259- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Respiratory viral infections research
- Immunodeficiency and Autoimmune Disorders
- Pneumonia and Respiratory Infections
- Food Allergy and Anaphylaxis Research
- Nutrition, Health and Food Behavior
- Tracheal and airway disorders
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Food Quality and Safety Studies
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
- Cytomegalovirus and herpesvirus research
- Invertebrate Immune Response Mechanisms
- Drug-Induced Adverse Reactions
- SARS-CoV-2 and COVID-19 Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Insect symbiosis and bacterial influences
- Urticaria and Related Conditions
Incheon Medical Center
2015-2024
St. Vincent's Hospital
2024
University of Ulsan
2017
Asan Medical Center
2015-2017
Ulsan College
2017
Sejong University
2011-2015
Seoul Medical Center
2015
Samsung Medical Center
2014
Sungkyunkwan University
2014
Boramae Medical Center
2012-2013
The prophenoloxidase (proPO) activation pathway, like the vertebrate complement system, consists of a protease cascade and functions as non-self-recognition system in these animals. Determining molecular mechanism by which pattern recognition molecules differentiate non-self from self transduce signals that stimulate defense responses is key for understanding ways innate immune systems are regulated. However, proPO poorly defined at level. proPO-activating insect Holotrichia diomphalia...
The prophenoloxidase (proPO) cascade is a major innate immune response in invertebrates, which triggered into its active form by elicitors, such as lipopolysaccharide, peptidoglycan, and 1,3-β-d-glucan. A key question of the proPO system how pattern recognition proteins recognize pathogenic microbes subsequently activate system. To investigate biological function 1,3-β-d-glucan protein system, we isolated eight different 1,3-β-d-glucan-binding from hemolymph large beetle (Holotrichia...
Gadoxetic acid and diffusion-weighted imaging (DWI) is increasingly used for the diagnosis of hepatocellular carcinoma (HCC). It relevant to refine diagnostic parameters HCC, using state-of-the-art techniques.To validate usefulness magnetic resonance (MRI) criteria with gadoxetic acid-enhanced MRI DWI small HCC by differentiation from dysplastic nodule (DN) or regenerative (RN) in cirrhotic patients strongly suspected HCC.One hundred eight 102 HCCs 29 benign nodules including 21 DNs two...
Abstract Background Respiratory infections among children, particularly community-acquired pneumonia (CAP), is a major disease with high frequency outpatient and inpatient visits. The causes of CAP vary depending on individual susceptibility, the epidemiological characteristics community, season. We performed this study to establish nationwide surveillance network system identify causative agents for antibiotic resistance in Korean children CAP. Methods monitoring was composed 28 secondary...
Objectives The purpose of this study was to evaluate the effectiveness real‐time fusion imaging (sonography combined with computed tomography or magnetic resonance imaging) for percutaneous sonographically guided biopsy focal hepatic lesions poor sonographic conspicuity. Methods This conducted as a retrospective analysis prospective database and approved by Institutional Review Board. Patients who had target conspicuity on B‐mode sonography were enrolled in study. Lesion assessed...
Abstract In human intestinal epithelial cells, IFN-γ induces BAFF expression through the signaling pathway of JAK/STAT and GAS, in promoter region gene. plays an important role development B cells. Here, we investigated effect on induced soluble membrane-bound production a dose- time-dependent manner. IFN-γ-induced release from polarized cells was observed apical basolateral compartments. JAK I inhibitor suppressed expression. Moreover, enhanced STAT1 phosphorylation IRF-1. Transient...
Croup is a common pediatric respiratory illness with symptoms of varying severity. Moreover, epiglottitis rare disease that can rapidly progress to life-threatening airway obstruction. Although the clinical course and treatments differ between croup epiglottitis, they are difficult differentiate on presentation. We aimed compare characteristics in Emergency Department patients.The 2012 National Information System database 146 Korean Departments was used investigate patients aged ≤18 years...
Abstract Background Aseptic meningitis is a relatively frequent childhood disease and virologic data suggest that enteroviruses are the commonest etiologic agents. We evaluated epidemiologic characteristics of aseptic in Daejeon, South Korea from 1987 to 2003. Methods 2201 medical records children with admitted The Catholic University Korea, Daejeon St Mary's Hospital were retrospectively analyzed. Results Outbreaks observed 1990, 1993, 1996, 1997, 2001 2002. age distribution cases was...
Purpose Understanding changes in pathogen and pneumonia prevalence among pediatric patients is important for the prevention of infectious diseases. Methods We retrospectively analyzed data children younger than 18 years diagnosed with at 117 Emergency Departments Korea between 2007 2014. Results Over study period, 329,380 cases were identified. The most frequent age group was 1–3 old (48.6%) next less 12 months (17.4%). Based on International Classification Diseases, 10th revision diagnostic...
Background: There is a lack of studies about which factors affect the quality life (QoL) in children with atopic dermatitis (AD), although it well known that AD has considerably negative effects on their QoL. Objective: This study aimed to measure QoL and identify Methods: A questionnaire derived from Children’s Dermatology Life Quality Index (CDLQI) was used Family history, allergic comorbidities, exacerbation-related factors, time exacerbation, previous current treatment were also...
Abstract RT is commonly used to treat malignant tumors. However, tumor regrowth a major limitation as an antitumor treatment. In the present study, we investigated tumor-promoting effects of high-dose (or ablative) treatments on tumor-bearing mice. We focused role macrophages that interact with IR-CCs in TME, which cause regrowth. observed CT26(H-2d) growth was enhanced by i.v. injection IR-CT26 cells compared NR control CT26 cells. The levels iNOS gene expression and NO production from...
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder that leads to secondary dysfunction. PCD rare disease, and data on it are limited in Korea. This study systematically evaluated the clinical symptoms, diagnostic characteristics, treatment modalities of pediatric Korea.This Korean nationwide, multicenter study, conducted between January 2000 August 2022, reviewed medical records patients diagnosed with PCD. Prospective studies have been added determine whether...
The report of adverse events following immunization (AEFI) in Korea has continued since 1994, and the most frequently reported cases AEFI Centers for Disease Control Prevention (KCDC) is bacille Calmette-Guérin (BCG). Meanwhile, various inoculation methods strains have been used past 6 years Korea. Therefore, we investigated BCG by strain types using safety surveillance KCDC.We reviewed AEFIs registered KCDC from January 2013 to June 2018.There were 336 during period, average time interval...
A national immunization program (NIP) to prevent disease and reduce mortality from vaccine preventable diseases (VPD) is very important.We analyzed only the anaphylaxis cases that occurred between 2001 2016 Korea Centers for Disease Control Prevention (KCDC) determined had a definite causal relationship with vaccine. The clinical symptoms were assessed according Brighton Collaboration case definition (BCCD) level.During period, there 13 of vaccine-related anaphylaxis. median age was 9 years...
Transient hypogammaglobulinemia of infancy (THI) is originally defined as a physiological maturation defect immunoglobulin G (IgG) production that occurs at 3-6 months age and lasts until 18 to 36 age.We report here on 22month-old child with THI IgA deficiency, who had massive pneumococcal empyema.Her depressed IgG level returned normal within 6 months, but was still low yr age.Although an age-dependent self-limiting disorder, severe infection includes atypical presentation may occur in some...
Understanding the patterns of emergency department (ED) visits patients with asthma is important for disease control and prevention exacerbations.This study aimed to investigate characteristics adult who visited EDs because their asthma.Patients asthma, ages ≥19 years old, 117 throughout Korea between January 2007 December 2012 were identified in National Emergency Department Information System (NEDIS) data base using International Classification Disease, 10th revision, codes J45 (asthma)...
Purpose: This study was aimed to investigate the clinical and epidemiological characteristics of patients with acute bronchiolitis who visited in 146 Emergency Departments (EDs) Korea 2012. Methods: We used NEDIS (National Department Information System) database obtain all children ED under age 3 between January 1, 2012 December 31, Results: Totally 18,313 were enrolled at this study. The male female ratio 1.55:1 mean 10 months. peak proportion 17.3% November during whole year. most common...
<h2>Abstract</h2> A cluster study to classify atopic dermatitis (AD) phenotypes into subgroups is required better understand and manage the disease owing heterogeneity of its clinical features. This aimed identify phenotypic childhood AD according allergic sensitization. In 258 children with AD, hierarchical analysis based on specific immunoglobulin (Ig) E sensitization revealed four distinct clusters. Cluster (n = 71) no IgE sensitization, whereas B 28) showed egg white only. was highly...