A5100701579- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Respiratory and Cough-Related Research
- Sepsis Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Dermatology and Skin Diseases
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Contact Dermatitis and Allergies
- Eosinophilic Esophagitis
- NF-κB Signaling Pathways
- Cardiac Arrest and Resuscitation
- IL-33, ST2, and ILC Pathways
- Renal function and acid-base balance
- Pharmacological Effects of Natural Compounds
- Osteoarthritis Treatment and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Diverse Approaches in Healthcare and Education Studies
- Urticaria and Related Conditions
- Tracheal and airway disorders
- Health and Wellbeing Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ocular Surface and Contact Lens
Yonsei University
2016-2025
Severance Hospital
2015-2025
Gangnam Severance Hospital
2017-2025
Kyushu University
2012-2023
Korea Institute of Brain Science
2017-2023
Konkuk University
2023
University of Ulsan
2022
Asan Medical Center
2022
Seoul National University Bundang Hospital
2022
Uijeongbu St. Mary's Hospital
2019
Abstract Operations strategy is formed via complex processes that transpire in multiple directions at organizational levels. While most previous studies focus on the “macro‐level” process of formation from dominant top‐down perspective, this study investigates “micro‐level” governs interactions among competitive priorities, objectives, and action plans within operations. Using 111 (59 52 bottom‐up) collected six German manufacturing plants, we build Kim Arnold's (1996) framework propose an...
The rapid development in big data analytics and the data-rich environment of intensive care units together provide unprecedented opportunities for medical breakthroughs field critical care. We developed validated a machine learning-based model, Pediatric Risk Mortality Prediction Tool (PROMPT), real-time prediction all-cause mortality pediatric units. Utilizing two separate retrospective observational cohorts, we conducted model validation using learning algorithm with convolutional neural...
The purpose of this study is to determine the sensibility each imaging tool in identifying focal cortical dysplasia (FCD) children and adolescents with epilepsy define prognostic factors pediatric adolescent surgery.We identified 48 FCD who underwent resective surgery analyzed their preoperative data. results various anatomic functional neuroimaging studies were compared for accuracy locating lesion. We also investigated clinical that affected outcome surgical treatment.Brain magnetic...
Methylsulfonylmethane (MSM), also known as dimethyl sulfone and methyl sulfone, is an organic sulfur-containing compound that occurs naturally in a variety of fruits, vegetables, grains, animals, including humans. In the present study, we demonstrated anti-inflammatory effects MSM lipopolysaccharide (LPS)-stimulated murine macrophages, RAW264.7 cells. significantly inhibited release nitric oxide prostaglandin E(2) by alleviating expression inducible synthase cyclooxygenase-2 LPS-stimulated...
We synthesized core/shell structured monodisperse semi-conducting polystyrene/polyaniline (PS/PANI) composite microspheres, and studied their electro-responsive electrorheological (ER) performance under an applied electric field strength when dispersed in silicone oil. An over-layer of the conducting PANI is formed by a controlled releasing process aniline pre-adsorbed on PS seed latex without any surface modification, which microspheres were readily prepared dispersion polymerization...
Purpose: Age-based causes and clinical characteristics of immediate-type food allergy (FA) have not been sufficiently studied.Therefore, we investigated age-dependent profiles FA in Korean children through an extensive multicenter investigation.Methods: Using a case report form developed by the authors, retrospective medical record review was performed patients (0-18 years old) diagnosed with between September 2014 August 2015 14 tertiary hospitals Korea.Results: A total 1,353 adolescents,...
3,3-Diindolylmethane (DIM) is a major in vivo product of acid-catalyzed oligomerization indole-3-carbinol (I3C) derived from Brassica food plants. Although DIM known as chemopreventive and chemotherapeutic phytochemical, the effects on inflammation are still unknown. In present study we investigated antiinflammatory experimental colitis colitis-associated colorectal carcinogenesis.To determine if has an effect vivo, examined therapeutic dextran sodium sulfate (DSS)-induced colon...
Multiple surface markers have been utilized for the enrichment of bone marrow mesenchymal stromal cells (MSCs) and to define primitive stem cells. We classified human marrow-derived MSC populations according tissue nonspecific alkaline phosphatase (TNAP) activity. TNAP expression varied among unexpanded primary MSCs, its level was not related colony-forming activity or putative markers, such as CD105 CD29, donor age, gender. levels were increased in larger cells, a unit-fibroblast assay...
Abstract The properties of regenerated cartilage using bone marrow‐derived mesenchymal stem cells (MSCs) and poly lactic‐ co ‐glycolic acid (PLGA) scaffold composites pretreated with TGF‐β3 were investigated compared to the non‐TGF‐β3 treated MSCs/PLGA in a rabbit model. We prepared it for 3 weeks prior transplantation. Then, transplanted osteochondral defect knee. After 12 transplantation, 10 rabbits which showed cartilaginous regeneration. In gross morphology, smooth, flush, transparent...
Background: Anaphylaxis is increasing in young children.The aim of the present study was to analyze clinical characteristics anaphylaxis Korean infants, with a focus on food triggers. Methods:The analyzed medical records infants aged 0 2 years old who had been diagnosed 23 secondary or tertiary hospitals Korea.Results: We identified 363 cases infantile (66.9% male).Cutaneous symptoms were most prevalent (98.6%), followed by respiratory (83.2%), gastrointestinal (29.8%), and neurologic...
Abstract In most sporadic gastric carcinomas, microsatellite instability (MSI) originates from inactivation of the hMLH1 gene by promoter hypermethylation. However, methylation patterns other genes and their consequences in high MSI (MSI‐H) carcinomas are not well characterized. To address aberrant profiles MSI‐H six ( , p16 INK4A E‐cadherin, Rb, RASSF1A VHL ) CpG island methylator phenotype (CIMP) were explored 36 results compared with those 43 microsatellite‐stable (MSS) carcinomas....
Chondrogenesis involves the recruitment of mesenchymal cells to differentiate into chondroblasts, and also must synthesize a cartilage-specific extracellular matrix. There were two representative culture systems that promoted chondrogenic differentiation human stem cells. These adaptations "pellet" system, which was originally described as method for preventing phenotypic modulation chondrocytes, "alginate bead" used maintain encapsulated at their differentiated phenotype over time, it...
Cyclooxygenase-2 (COX-2) inhibitors suppress bone repair and formation by suppressing angiogenesis as well potentially interfering with osteoblast osteoclast functions. In spite of these reports, there is a controversy over the exact effects COX-2 on processes itself. This work was designed to investigate effect inhibitor osteogenesis human marrow-derived mesenchymal stem cells (MSC). MSCs in were treated (celecoxib naproxen) absence or presence interleukin-1β (IL-1β), which used induce...
Abstract Although understanding the high-resolution spatial distribution of bioactive small molecules is indispensable for elucidating their biological or pharmacological effects, there has been no analytical technique that can easily detect naïve molecular localization in mammalian tissues. We herein present a novel situ label-free imaging visualizing molecules, using polyphenol. established 1,5-diaminonaphthalene (1,5-DAN)-based matrix-assisted laser desorption/ionization-mass spectrometry...