A5100655295- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Respiratory Support and Mechanisms
- Immune Cell Function and Interaction
- Tracheal and airway disorders
- Kawasaki Disease and Coronary Complications
- Food Allergy and Anaphylaxis Research
- IL-33, ST2, and ILC Pathways
- Urticaria and Related Conditions
- Viral Infections and Immunology Research
- Congenital Anomalies and Fetal Surgery
- Congenital Diaphragmatic Hernia Studies
- Eosinophilic Disorders and Syndromes
- Bacterial Infections and Vaccines
- Hepatitis Viruses Studies and Epidemiology
- Child Nutrition and Water Access
- Health and Wellbeing Research
- Mechanical Circulatory Support Devices
- Hematopoietic Stem Cell Transplantation
Catholic University of Korea
2015-2024
National Center for Advancing Translational Sciences
2021
National Institutes of Health
2014-2021
Uijeongbu St. Mary's Hospital
2016-2019
Cheil General Hospital and Women's Healthcare Center
2018
Dankook University
2018
Catholic University of Daegu
2016
Chosun University
2016
Bucheon St. Mary's Hospital
2012-2015
Gyeongnam National University of Science and Technology
2014
Although triglyceride accumulation in the liver causes non-alcoholic fatty disease (NAFLD), hypercholesterolemia is also a main cause of NAFLD as well atherosclerosis. However, and atherosclerosis have not been investigated simultaneously animal models fed high-cholesterol diet. Moreover, it unclear whether systemic inflammation can exacerbate both pathologies same model. Accordingly, this study effect additional on induced by cholesterol overload wild animals. New Zealand white rabbits were...
Alterations of cholesterol metabolism are responsible for vasospastic angina and atherosclerosis. To comprehensively evaluate metabolism, 18 sterols, including cholesterol, 6 cholesteryl esters (CEs), 3 precursors, 8 hydroxycholesterols (OHCs), were simultaneously analyzed using hybrid solid-phase extraction (SPE) purification coupled to high-temperature gas chromatography-mass spectrometry (HTGC-MS). Methanol-based SPE increased the selective extraction, HTGC resulted in a good...
Background: Anaphylaxis is increasing in young children.The aim of the present study was to analyze clinical characteristics anaphylaxis Korean infants, with a focus on food triggers. Methods:The analyzed medical records infants aged 0 2 years old who had been diagnosed 23 secondary or tertiary hospitals Korea.Results: We identified 363 cases infantile (66.9% male).Cutaneous symptoms were most prevalent (98.6%), followed by respiratory (83.2%), gastrointestinal (29.8%), and neurologic...
Metabolic syndrome and dyslipidemia contribute to the development of a pro-inflammatory state in asthma. However, studies investigating association between asthma have reported conflicting results. This study aimed uncover relationship lipid profiles adolescents using national health nutrition survey.This cross-sectional analyzed 2010-2012 Korea National Health Nutrition Examination Survey data included 2841 subjects aged 11-18 years with fasting blood sample data. Serum total cholesterol...
Enterovirus 71, one of the enteroviruses that are responsible for both hand-foot-and-mouth disease and herpangina, can cause neural injury. During periods endemic spread hand-foot-andmouth caused by enterovirus CNS infections also frequently diagnosed may lead to increased complications from injury, as well death. We present results our epidemiologic research on clinical manifestations children with 71.The study group consisted 42 patients admitted infection 71 between April 2009 October at...
Activation of cell surface CD30 by immobilized anti-CD30 monoclonal antibodies (mAb) induces strong apoptosis in human eosinophils. This mAb-induced eosinophil is inhibited the addition inhibitors p38, ERK1/2 mitogen-activated protein kinases, and phosphatidylinositol 3-kinase. However, there little data investigating role Bcl-2 caspases induced mAb. We sought to determine whether mAb via caspase pathways.Peripheral blood was drawn from 37 healthy volunteers. The expression on eosinophils...
Purpose This study aimed to evaluate the autonomic imbalance in syncope by comparing baseline heart rate variability (HRV) between healthy children and those with vasovagal syncope. Methods To characterize profile experiencing syncope, we evaluated HRV of 23 patients aged 7-18 years 20 children. These were divided into preadolescent (<12 years) adolescent groups. The following time-domain indices calculated: root mean square successive differences (RMSSD); standard deviation all average R-R...
Background Pentraxin 3 (PTX-3) is an acute-phase protein that increases in the plasma during inflammation. Objective We aimed to evaluate usefulness of PTX-3 as a clinical marker children with lower respiratory tract infection (LRTI) and examine correlation other biomarkers such C-reactive (CRP) procalcitonin (PCT). Methods enrolled 117 consecutive patients admitted Seoul St. Mary's Hospital LRTI using WHO criteria. recorded data on fever duration peak temperature before admission, after...
The Immunogenicity and Safety of a Combined DTaP-IPV//Hib Vaccine Compared with Individual DTaP-IPV Hib (PRP~T) Vaccines: A Randomized Clinical Trial in South Korean Infants Recommended infant vaccination Korea includes vaccines administered as separate injections.In this randomized, open, controlled study we assessed the non-inferiority immunogenicity pentavalent combination vaccine (Pentaxim™) compared licensed vaccines.We enrolled 418 healthy infants to receive either (n = 206) or 208) at...
The purpose of this study was to expand our knowledge small RNAs, which are known function within protein complexes modulate the transcriptional output cell. Here we describe two previously unrecognized, termed pY RNA1-s1 and RNA1-s2 (processed Y RNA1-stem −1 −2), thereby expanding list RNAs. were discovered by RNA sequencing found be 20-fold more abundant in retina than 14 other rat tissues. Retinal expression RNAs is highly conserved, including human retina, occurs all retinal cell layers....
The impact of the coronavirus disease 2019 (COVID-19) pandemic on Kawasaki (KD) has not yet been established. We investigated changes in observed number and severity KD cases accompanying coronary artery complications during COVID-19 Korea.This retrospective observational study included patients aged < 18 years with acute-phase diagnosed between March 2018 February 2021. Data were extracted from Clinical Warehouse that houses data five affiliated university hospitals Korea. analyzed patient...
Eosinophil Cationic Protein and Chemokines in Nasopharyngeal Secretions of Infants with Respiratory Syncytial Virus (RSV) Bronchiolitis Non-RSV is a risk factor for the development childhood asthma.Eosinophilic inflammation airways plays an important role pathophysiology both bronchiolitis asthma.To investigate this inflammation, we measured eosinophil cationic protein (ECP), regulated on activation normal T-cell expressed secreted (RANTES) eotaxin levels nasopharyngeal secretions...
Asthma during adolescence can induce social, psychological, and behavioral problems. We examined the impact of asthma other allergic diseases on psychological symptoms health risk behaviors among South Korean adolescents.In this population-based cross-sectional study, 3192 adolescents (10-18 years age) participating in 2008-2011 National Health Nutrition Examination Survey were enrolled. Psychological problems associated with clinically diagnosed asthma, rhinitis, atopic dermatitis assessed...
Background House dust mites (HDMs) are important sources of indoor allergens. Seventeen components have been identified from Dermatophagoides pteronyssinus (Der p). Objective Our aim was to define the prevalence specific IgE Der p in Korea and investigate clinical features them children with allergic disease. Methods We performed a prospective evaluation 80 HDM sensitized patients history rhinitis (AR), atopic dermatitis (AD), asthma urticaria (UC). Patients underwent ImmunoCAP for total...
Chronic rhinosinusitis (CRS) is a commonly diagnosed disease that has significant impact on child's quality of life. However, no useful biomarker available to identify antibiotic-responsive CRS. We determined the significance eosinophil-related markers and total IgE levels in childhood CRS with regard antibiotic response.This was case-control study patients admitted Uijeongbu St. Mary's Hospital between November 2010 2011 CRS.In this analytical cross-sectional study, we identified children...
Lidocaine, a local anaesthetic is treatment option in uncontrolled asthma due to its immunomodulatory effects. In the present study, proparacaine (PPC), derivative of lidocaine was examined for therapeutic application mouse model allergic rhinitis.The mice were grouped into 4 groups: control group, rhinitis (AR) ciclesonide (CIC) and PPC group. Nasal symptom scores, eosinophil counts, goblet cell mast cells counts nasal mucosa measured. Serum ovalbumin (OVA)-specific immunoglobulin (Ig) E,...
Given that YKL-40 is a known marker of inflammation, we sought to determine its association with urinary tract infection (UTI) in febrile children. In total, 44 children aged 0 24 months UTI and 35 age- sex-matched controls fever from other causes were enrolled the study. ELISA was performed level urine collected each child. The ratio creatinine (Cr) higher than (P<0.001). area under ROC curve for detecting 0.88 YKL-40/Cr ratio, 0.86 pyuria, 0.71 positive nitrite on urinalysis. We applied...
In 2007, the American College of Obstetricians and Gynecologists (ACOG) recommended that all pregnant women be offered screening or diagnostic tests for chromosomal abnormalities regardless their age. Noninvasive prenatal testing (NIPT) common aneuploidies was introduced as a test in case high-risk pregnancies. We assessed rates aged 35 years older.A retrospective study conducted to compare amniocentesis, chorionic villus sampling (CVS), serum screening, NIPT from January 2005 through March...
Researchers have shown that eosinophil peroxidase (EPO) is a relatively accurate marker of eosinophilia and activity. However, its use as eosinophilic inflammation in nasal secretions limited because the diagnostic cutoff values EPO for one-time test allergic diseases such rhinitis not been established. To identify correlation between count children adolescents with rhinitis. We recruited patients <18 years age more than 2 weeks or episodes year whose were measured at single allergy clinic....
We investigated the mechanism or mechanisms by which rebamipide protects against gastric mucosal inflammation associated with Helicobacter pylori. The production of interleukin (IL)-8 in association expression IL-8 mRNA was greatly increased H. pylori-infected Kato III cells a concentration- and time-dependent manner, whereas secretion IL-6 tumor necrosis factor-alpha not detectable. were significantly inhibited (100-1000 microM) concentration-dependent manner....