A5030667338- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Antibiotic Resistance in Bacteria
- Virology and Viral Diseases
- Pediatric health and respiratory diseases
- Tuberculosis Research and Epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Neonatal and Maternal Infections
- Virus-based gene therapy research
- Antimicrobial Resistance in Staphylococcus
- Urinary Tract Infections Management
- Microbial infections and disease research
- Immunodeficiency and Autoimmune Disorders
- Hepatitis B Virus Studies
- Herpesvirus Infections and Treatments
- Vaccine Coverage and Hesitancy
- Neonatal Respiratory Health Research
- Bacterial Identification and Susceptibility Testing
- Viral Infections and Immunology Research
Seoul National University
2014-2023
Seoul National University Children's Hospital
2011-2020
Seoul National University Hospital
2010-2019
Japan Pediatric Society
2019
New Generation University College
2003-2018
Seoul National University Bundang Hospital
2015-2018
National University College
2003-2018
Kangwon National University
2018
Eulji University
2018
Chonnam National University
2018
This study was performed to evaluate the associations of newly recognized viruses, namely, human metapneumovirus (hMPV), coronavirus (HCoV)-NL63, and bocavirus (HBoV) with lower respiratory tract infections (LRTIs) in previously healthy children.To determine prevalences 11 viruses--respiratory syncytial virus (RSV), adenovirus, rhinovirus, parainfluenza viruses (PIVs) 1 3, influenza A B, hMPV, HCoV, HCoV-NL63, HBoV--among infants or children LRTIs, association their epidemiologic...
ABSTRACT To determine the epidemiologic features and clinical outcomes of bloodstream infections caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli Klebsiella pneumoniae isolates, cases bacteremia these organisms in children were analyzed retrospectively. Among 157 blood isolates recovered from 1993 to 1998 at Seoul National University Children's Hospital, prevalence ESBL production was 17.9% among E. 52.9% K. isolates. The commonest ESBLs SHV-2a TEM-52. A novel ESBL,...
Despite the concern of replacement disease, notably by serotype 19A after 7-valent conjugate vaccine (PCV7) use, was increasingly recognized in Korean children before introduction PCV7. To understand dynamics serogroup 19 prevalence from 1991-2006, we serotyped 538 pediatric pneumococcal isolates. Serogroup isolates (n = 126) were characterized antimicrobial drug susceptibility, presence mefA/ermB, and multilocus sequence typing. Overall, proportion increased but 19F decreased. Among <5...
Respiratory syncytial virus (RSV) is a major health problem in young children, and host response to severe disease favors Th2 immune response. To investigate the genetic basis for RSV severity, linked variants of 3 cytokine genes, IL4, IL13, IL5 (which are clustered on chromosome 5q31.1) were characterized 105 children who hospitalized with infection 315 Korean control subjects pilot study. A common IL4 haplotype defined at 5 loci, which includes -589T promoter variant, previously shown be...
In Korea, Mycoplasma pneumoniae was detected in 255/2,089 respiratory specimens collected during 2000-2011; 80 isolates carried 23S rRNA gene mutations, and 69/123 culture-positive samples with the mutation were resistant to 5 macrolides. During 2000-2011, prevalence of increased substantially. These findings have critical implications for treatment children mycoplasma pneumonia.
The major aims of this study were to estimate the infection rate and recognize risk factor for ventriculoperitoneal (VP) shunt infections in children. To analyze identify factors, a retrospective cohort analysis 333 consecutive VP series was performed at Seoul National University Children's Hospital Korea between January 2005 February 2011. Overall, 35 shunts (10.5%) infected, which represented an 0.075 cases per year. occurred median 1 month (range, 6 days 8 months) after insertion. An...
ABSTRACT Adenovirus is an important cause of respiratory infections in infants and children. Fifty-one serotypes have been identified, adenovirus type 3 (Ad3) Ad7 often associated with outbreaks severe tract infections. Each serotype can be further divided into genome types based on the patterns digestion their DNAs restriction enzymes. DNA analysis was performed 56 strains Ad3 98 by using 12 enzymes recognizing 6 bp ( Bam HI, Bcl I, Bgl II, Bst EII, Eco RI, Hin dIII, Hpa Sal Sma Xba Xho I)....
Abstract Among the 53 serotypes of human adenoviruses (HAdVs), identified to date, only a limited number have been associated with respiratory infections. The epidemiology each differs depending on location and/or time surveillance. This study was performed elucidate HAdV infections by comprehensive serotyping HAdVs isolated from tract Korean children. specimens children over 17 consecutive years (1991–2007) were typed neutralization test or molecular methods, including two‐sets multiplex...
ObjectivesThis ambidirectional intervention study was performed to examine the impact of a change in antibiotic policy on extended-spectrum β-lactamase (ESBL) prevalence children's hospital with high ESBL production among Escherichia coli and Klebsiella pneumoniae.
Bacterial meningitis remains a serious cause of morbidity and mortality in childhood, despite the availability effective vaccines against Haemophilus influenzae type b (Hib) or Streptococcus pneumoniae. The purpose this study was to analyze data on bacterial cases Korea from 1996 through 2005. information all hospitalized bacteria-proven obtained 17 university hospitals nationwide. A total 402 were identified. Of these, 125 (29.9%) neonates. agalactiae most common bacteria responsible for 99...
Immunization Program Vaccines and Non-NIP in KoreaThis study aimed to describe the differences vaccination coverage between National (NIP) vaccines non-NIP Korea identify factors affecting difference.Nationwide face-to-face interview-based questionnaire survey among randomly selected 4,374 participants aged 7-83 months was conducted.Vaccination analyzed according birth cohorts, geographic areas, sociodemographic characteristics.We found that NIP recorded higher primary compared (95.9%-100%...
Objectives This study aims to describe the clinical characteristics of enteroviral meningitis in association with absence cerebrospinal fluid (CSF) pleocytosis. Design was a retrospective analysis databases patients diagnosed by CSF reverse transcription-PCR testing. Presence non-pleocytosis at each age group analysed use two criteria. Clinical variables were compared regard presence Multiple logistic regression used identify factors that associated Setting Two hospitals South Korea, between...
There were many reports of longitudinal changes in the causative organisms neonatal sepsis Western countries but few Asia. We aimed to study trends epidemiology at Seoul National University Children's Hospital (SNUCH), a tertiary center Korea, and compared results previous studies countries. The medical records all neonates who hospitalized SNUCH from 1996 2005 with positive blood cultures reviewed. also findings 16-yr (1980-1995). One hundred forty-nine identified 147 episodes 134 infants....
Background Radiologic evaluation of children with Mycoplasma pneumoniae is important for diagnosis and management. Objective To investigate the correlation between chest radiographic findings clinical features in pneumonia. Materials methods This study included 393 hospitalized diagnosed M. pneumonia January 2000 August 2016. Their radiographs were reviewed. Radiographic categorized grouped as consolidation group (lobar or segmental consolidation) non-consolidation (patchy infiltration,...
Viral etiologic agents of acute lower respiratory tract infections were studied from November, 1990, through April, 1994, in Korean children. From 712 children who visited or admitted to Seoul National University Children's Hospital because infections, 804 nasal aspirates collected; viral detected by virus isolation and antigen was indirect immunofluorescent staining. One more identified 369 (45.9%) cases; which 3.3% mixed infections. The pathogens syncytial (27.2%), parainfluenza type 3...
To study genetic variation and molecular epidemiology of the G protein respiratory syncytial virus (RSV), 253 strains from a children's hospital in Korea over 9 consecutive epidemics were analyzed. Restriction analysis entire gene demonstrated 24 genotypes among 188 subgroup A 6 65 B isolates. Two to 4 dominant cocirculated, different predominated each epidemic. Predominant replaced with new during epidemics. One 2 alternately or concurrently. Phylogenetic revealed that there multiple...
Objective. In connection with the possible relationship between Mycoplasma infection and onset of asthma, several studies have shown not only a high level serum total immunoglobulin E (IgE) but also production IgE specific to or common allergens during course infection. It has been suggested that balance T helper type 1 (TH1)/T 2 (TH2) immune response may regulate synthesis IgE. The objective this study was investigate pattern cytokine (TH1 TH2) an episode acute lower respiratory tract...
As complications of tuberculosis are frequent in infancy, correct diagnosis infants is important. The purposes this study to summarize radiographic and CT findings pulmonary determine the radiologic features frequently seen with disease.Frequent mediastinal or hilar lymphadenopathy central necrosis air-space consolidations, especially masslike consolidations low-attenuation areas cavities within consolidation. Disseminated nodules airway also detected age group. a useful diagnostic technique...
Background: Diagnosis of Mycoplasma pneumoniae pneumonia is challenging because the lack standardized rapid tests. Many serologic tests and polymerase chain reaction (PCR) based methods are used with different diagnostic criteria. Methods: This retrospective study was conducted to compare values indirect particle agglutination test nested PCR nasopharyngeal aspirates for diagnosis M. in children. These assays were evaluated 234 hospitalized children community-acquired lower respiratory tract...
Background: Human coronavirus NL63 (HCoV-NL63) has recently been implicated as a common cause of croup in children. This study was performed to evaluate viruses associated with children, an emphasis on HCoV-NL63. Methods: Nasopharyngeal aspirates were prospectively collected from 182 children hospitalized at Seoul National University Bundang Hospital January 2005 June 2009. Multiplex reverse-transcriptase polymerase chain reaction conducted for detection 11 respiratory viruses, and medical...
The purpose of this study was to identify the major etiological agents responsible for invasive bacterial infections in immunocompetent Korean children.We retrospectively surveyed children caused by eight pediatric bacteria, namely Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, agalactiae, pyogenes, Listeria monocytogenes, and Salmonella species that were diagnosed at 18 university hospitals from 1996 2005.A total 768 cases identified.S....
This study investigated the clinical details and epidemiology of imipenem-resistant Acinetobacter baumannii (IRAB) outbreak that occurred at a pediatric intensive care unit (PICU), describes successful outcome implemented infection control measures.With recognition 3 clustered cases with IRAB bacteremia PICU Seoul National University Children's Hospital, Korea, from August to September 2010, following strategies were implemented: reinforcement hand hygiene contact precautions, investigation...