Context: The dietary iodine intake of lactating women has been reported to be high in Korea. Objectives: aim this study was assess balance and determine its relationship with thyroid function preterm infants. Design: Thyroid functions infants born at 34 wk gestation or less were evaluated the first (n = 31) third 19) weeks. Mothers’ breast milk (BM) random urine samples taken on same days for tests. Results: Iodine concentrations BM very (198–8484 μg/liter), one had an more than 100 μg/kg...

Objectives This study aims to describe the clinical characteristics of enteroviral meningitis in association with absence cerebrospinal fluid (CSF) pleocytosis. Design was a retrospective analysis databases patients diagnosed by CSF reverse transcription-PCR testing. Presence non-pleocytosis at each age group analysed use two criteria. Clinical variables were compared regard presence Multiple logistic regression used identify factors that associated Setting Two hospitals South Korea, between...

There were many reports of longitudinal changes in the causative organisms neonatal sepsis Western countries but few Asia. We aimed to study trends epidemiology at Seoul National University Children's Hospital (SNUCH), a tertiary center Korea, and compared results previous studies countries. The medical records all neonates who hospitalized SNUCH from 1996 2005 with positive blood cultures reviewed. also findings 16-yr (1980-1995). One hundred forty-nine identified 147 episodes 134 infants....

We tested whether interleukin-6 (IL-6) in tracheal aspirate (TA) at birth, as a marker of fetal pulmonary inflammation, can be predictor bronchopulmonary dysplasia (BPD) preterm infants.A total 75 (< or = 32 wk) infants who were intubated the delivery room prospectively enrolled. Multivariate logistic regression analysis was done to determine IL-6 TA birth is an independent risk factor for BPD, and receiver-operating characteristic curve constructed accuracy predicting BPD.IL-6 BPD. Fetal...

To determine the validity of a repeat thyroid function test for preterm infants, and to investigate factors that influence functions 105 infants born at <32 weeks' gestational age were evaluated. Initial serum free thyroxine (fT4) thyrotropin (TSH) levels measured during first 10 days life, repeated tests performed more than 2 weeks apart. We analyzed effects age, systemic diseases, nutrition on development dysfunction. Thirty-one (30%) had low fT4 (<0.7 ng/dL) in absence elevated TSH (<7...

Currently, bronchopulmonary dysplasia (BPD) occurs almost exclusively in pre-term infants. In addition to prematurity, other factors like oxygen toxicity and inflammation can contribute the pathogenesis. This study aimed compare urinary inflammatory oxidative stress markers between no/mild BPD group moderate/severe cases with significant early lung disease respiratory distress syndrome (RDS) ('classic' BPD) minimal ('atypical' BPD). A total of 60 patients who were a gestational age < 30...

Incidence of Bronchopulmonary Dysplasia in KoreaA nationwide survey was conducted to determine the incidence bronchopulmonary dysplasia (BPD) Korea and intercenter differences survival BPD rates among preterm infants.Questionnaires were sent all registered neonatal intensive care units (NICUs).The questionnaires inquired about very low birth weight (VLBW, < 1,500 g) infants who had been admitted each NICU from 2007 2008.BPD defined as requiring oxygen at 36 weeks' postmenstrual age.Almost...

Purpose To describe the clinical characteristics of full-term neonates with hypocalcemia and to suggest factors associated neonatal Methods The medical records were reviewed. Hypocalcemia was defined as an ionized calcium (iCa) concentration <4 mg/dL. Parathyroid hormone (PTH) insufficiency a serum PTH level <60 pg/mL or phosphorus higher than in presence hypocalcemia. Results Fifty-three enrolled. median age at diagnosis 3 days. In all neonates, formula feeding predominance observed....

Conflicting results on the influences of histologic chorioamnionitis (HC) neonatal morbidities might be partly originated from using different definition HC.The aim this study was to determine relationship between HC and that reflects site extent inflammation.This a retrospective cohort 261 very low birth weight (VLBW) infants admitted at tertiary academic center.Based inflammation, categorized: any HC; amnionitis; funisitis; amnionitis+funisitis.The inflammation in each reflected by...

Recent Changes in the Incidence of Bronchopulmonary Dysplasia among Very-Low-Birth-Weight Infants KoreaWe investigated incidence bronchopulmonary dysplasia (BPD) very-low-birthweight (VLBW) infants Korea using Korean Neonatal Network (KNN) data.In total, 2,386 VLBW born from January 2013 to June 2014 were prospectively registered.BPD was defined as supplemental oxygen or positive pressure support at 36 weeks postmenstrual age (PMA).The overall BPD 28.9%, and mortality rate neonatal intensive...

There have been many studies supporting fluconazole prophylaxis in preterm infants for prevention of invasive fungal infections (IFIs). However, the routine use neonatal intensive care units (NICUs) raises concerns with respect to resistance development, including selection resistant Candida species. We aimed evaluate efficacy and safety extremely low birth weight (ELBW) infants. An interventional pre-post cohort study at two tertiary NICUs was conducted. Data from 5-year periods without...

Thyroid hormones are critical for growth and brain development during the newborn period infancy. Because of delayed maturation hypothalamic-pituitary-thyroid axis in preterm infants, thyroid dysfunction is common, stimulating hormone (TSH) elevation often infants. The objective this study was to determine incidence requiring levothyroxine treatment identify its risk factors infants.A retrospective cohort performed on infants who were born before 32 gestational weeks admitted a single...

Early identification of infants at higher risk developing bronchopulmonary dysplasia (BPD) may enable a targeted approach to reduce BPD. We aimed evaluate the hypothesis that interstitial pneumonia pattern on day 7 chest radiograph predicts BPD or death before 36 weeks postmenstrual age (PMA). A retrospective cohort study was performed 336 preterm (birth weight < 1500 g and gestational 32 weeks) who were admitted single tertiary academic center between January 2008 December 2014. Day...

Late-onset hyponatremia (LOH), occurring after two weeks of age with the achievement full feeding, is result a negative sodium balance caused by inadequate salt intake or excessive loss due to immature renal intestinal function in preterm infants. The aims our study were identify risk factors for LOH and its influence on neonatal outcomes. This was retrospective cohort analysis 161 infants born before 34 gestation between June 2009 December 2010 at Seoul National University Hospital. defined...

Purpose This study investigated blood glucose levels in preterm babies according to gestational age (GA). Methods Subjects were 141 infants with a GA<34 weeks. Data on levels, GA, body weight, infusion rate, and other contributing factors the first 7 days after birth analyzed. Hypoglycemia was defined as level of <40 mg/dL up 24 hours <50 thereafter. Hyperglycemia >180 mg/dL. Results During birth, hypo- hyperglycemia occurred 29 (29 141, 20.6%) 42 (42 29.8%) neonates, respectively. 2 hours,...

Bronchial hyperresponsiveness (BHR) is a characteristic feature of asthma, but it also frequently present in children and adults with chronic obstructive lung diseases. Bronchopulmonary dysplasia (BPD) disease, most commonly developing after mechanical ventilation oxygen therapy premature infants. BHR usually measured by bronchial challenges, using direct or indirect stimuli. The aim this study was to evaluate stimuli young BPD. Methacholine adenosine 5'-monophosphate (AMP) challenges were...

Abstract Background : Recently, atypical chronic lung disease (CLD) of prematurity that develops in the absence preceding respiratory distress syndrome (RDS) have been observed frequently. The specific risk factors for CLD are presumed to be different from those classical following RDS were assessed. Methods Prospective cohort analysis was done 115 very low‐birthweight infants who born Seoul National University Hospital, Seoul, Korea, and survived more than 36 weeks postmenstrual age or 28...

&lt;i&gt;Background:&lt;/i&gt; The authors previously demonstrated the priming effect of intra-amniotic lipopolysaccharide (LPS) on hyperoxic lung injury in a rat model bronchopulmonary dysplasia (BPD). &lt;i&gt;Objectives:&lt;/i&gt; To investigate mechanism underlying this by determining biochemical profiles BPD. &lt;i&gt;Methods:&lt;/i&gt; involved LPS administration and postnatal hyperoxia (85%). mRNA expressions &lt;i&gt;interleukin-6 (IL-6), vascular endothelial growth factor (VEGF),...