OBJECTIVE: To determine the immunologic effects of oropharyngeal colostrum administration in extremely premature infants. METHODS: We conducted a double-blind, randomized, placebo-controlled trial involving 48 preterm infants born before 28 weeks’ gestation. Subjects received 0.2 mL their mother’s or sterile water via route every 3 hours for days beginning at to 96 life. measure concentrations secretory immunoglobulin A, lactoferrin, and several immune substances, urine saliva were obtained...

<h3>Objective</h3> To compare non-invasive ventilation neurally adjusted ventilatory assist (NIV-NAVA) and pressure support (NIV-PS) in preterm infants on patient–ventilator synchrony. <h3>Design</h3> A randomised phase II crossover trial. <h3>Setting</h3> Neonatal intensive care units of two tertiary university hospitals Korea. <h3>Patients</h3> Preterm born &lt;32 weeks. <h3>Intervention</h3> NIV-NAVA NIV-PS were applied random order after ventilator weaning. Data recorded for sequential 5...

Various types of noninvasive respiratory modalities that lead to successful extubation in preterm infants have been explored. We aimed compare neurally adjusted ventilatory assist (NIV-NAVA) and nasal continuous positive airway pressure (NCPAP) for the postextubation stabilization infants. This retrospective study was divided into two distinct periods, between July 2012 June 2013 2014, because NIV-NAVA applied beginning 2013. Preterm less than 30 weeks GA who had intubated with mechanical...

Background Neonatal sepsis is associated with most cases of mortalities and morbidities in the neonatal intensive care unit (NICU). Many studies have developed prediction models for early diagnosis bloodstream infections newborns, but there are limitations to data collection management because these based on high-resolution waveform data. Objective The aim this study was examine feasibility a model by using noninvasive vital sign machine learning technology. Methods We used electronic...

Despite significant advances in neonatology, bronchopulmonary dysplasia (BPD) remains the most common cause of serious morbidity and mortality premature infants. The aim present study was to determine associations between respiratory severity score (RSS) with death or BPD infants.This a retrospective conducted January 2010 December 2014. We enrolled preterm infants gestational age less than 28 weeks who were supported by mechanical ventilation for more week during first 4 life. collected RSS...

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; White matter injury (WMI) is the most common form of brain in preterm infants. It could be induced by a systemic inflammatory response &lt;b&gt;&lt;i&gt;Objectives:&lt;/i&gt;&lt;/b&gt; We hypothesized that surgical necrotizing enterocolitis (surgNEC) results more severe WMI than spontaneous intestinal perforation (SIP) on magnetic resonance imaging (MRI) at term-equivalent age (TEA). &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; The medical...

Abstract Background Several studies have suggested that adverse neurodevelopment could be induced by systemic inflammation in preterm infants. We aimed to investigate whether infants with would impaired and which biomarkers neurophysiologic during are associated poor neurodevelopment. Methods This prospective cohort study enrolled born before 30 weeks of gestation or birth weight &lt; 1250 g. Infants were grouped according the presence inflammation: Control (no inflammation, n = 49), I...

Bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH) is a well-known complication of prematurity; however, the additional impact left-to-right interatrial shunt on this condition remains poorly understood. The aim present study was to identify significance atrial lesions in PH infants with moderate or severe BPD.The medical records 383 preterm (gestational age < 32 weeks) who were diagnosed BPD between 2005 and 2013 retrospectively reviewed. Baseline characteristics such...

Nutritional support is critical for preterm infants in the neonatal intensive care unit (NICU). A multidisciplinary nutritional team (NST) that focuses on providing optimal and individualized nutrition could be helpful. We conducted a thorough evaluation of clinical outcomes tertiary NICU following implementation an NST.This study used retrospective approach with historical comparisons. Preterm neonates < 30 weeks gestational age or weighing 1250 g were enrolled. Clinical compared before...

To evaluate clinical applicability of noninvasive hemoglobin (Hb) measurement with a pulse CO-oximeter in neonates.Prospective comparison study.Neonatal ICU.Fifty-six preterm and term infants median age = 20 days (range 1-98 days) weight 1,440 g 530-4,230 g).Hb measurements by Pulse CO-Oximetry (Masimo Radical-7) were recorded immediately prior to venous samplings.The collected data compared the corresponding Hb level obtained laboratory testing, total 137 pairs analyzed. Noninvasive values...

Thyroid hormones are critical for growth and brain development during the newborn period infancy. Because of delayed maturation hypothalamic-pituitary-thyroid axis in preterm infants, thyroid dysfunction is common, stimulating hormone (TSH) elevation often infants. The objective this study was to determine incidence requiring levothyroxine treatment identify its risk factors infants.A retrospective cohort performed on infants who were born before 32 gestational weeks admitted a single...

Abstract The immature preterm kidney is likely to be vulnerable acute injury (AKI). However, the biomarkers currently used for AKI are not sensitive or specific and also inadequate timely detection of in infants. objectives this study were identify novel urinary using proteomic techniques, verify validate that candidates can serve as early predictive AKI. In total, 1,810 proteins identified discovery phase. Among those proteins, 174 selected 1 st targeted proteins. A total 168 quantified,...

Abstract Background Severe bronchopulmonary dysplasia often leads to prolonged mechanical ventilation lasting several months. Cyanotic episodes frequently occur in these patients, necessitating long‐term sedation and/or intermittent muscle paralysis. Neurally adjusted ventilatory assist ( NAVA ) might provide precisely the amount of support that patients need without sedation. Methods We reviewed medical records preterm infants who underwent tracheostomy and required for &gt;6 months during...

Abstract Sildenafil is widely used off-label in pediatric patients with pulmonary arterial hypertension (PAH). This study was conducted to characterize the pharmacokinetics (PK) of sildenafil term and preterm neonates PAH, by developing a population PK model, suggest appropriate doses achieve clinically effective concentrations. A modelling analysis performed using its metabolite N-desmethyl (DMS) concentration data from 19 whose gestational ages ranged 24–41 weeks. They received orally at...

Abstract In this study, we aimed to comprehensively characterize the microbiomes of various samples from pregnant women and their neonates, explore similarities associations between mother-neonate pairs, sample collection sites, obstetrical factors. We collected vaginal discharge amniotic fluid in umbilical cord blood, gastric liquid, meconium neonates. identified 19,597,239 bacterial sequences 641 141 178 By applying rigorous filtering criteria remove contaminants, found evidence microbial...

Abstract Background This study aimed to evaluate whether mucous fistula refeeding (MFR) is safe and beneficial for the growth intestinal adaptation of preterm infants with enterostomies. Methods exploratory randomized controlled trial enrolled born before 35 weeks’ gestation enterostomy. If stomal output was ≥ 40 mL/kg/day, were assigned high-output MFR group received MFR. stoma &lt; normal-output or control group. Growth, serum citrulline levels, bowel diameter in loopograms compared. The...

Objectives: The aim of the present study was to report possible improvements in ventilator variables associated with a transition from synchronized intermittent mandatory ventilation neurally adjusted ventilatory assist preterm infants bronchopulmonary dysplasia who required high level mechanical support single center. Design: Retrospective study. Setting: Neonatal ICU. Patients: Twenty-nine median gestational age 25.4 weeks (range, 23.4–30.3 wk) and birth weight 680 g 370–1,230 g) were...

We investigated whether the extent of fetal growth restriction (FGR) in terms not only birth weight but length and head circumference at is correlated with an increased risk bronchopulmonary dysplasia (BPD) preterm infants.

Abstract Prematurity, size at birth, and postnatal growth are important factors that determine cardiometabolic neurodevelopmental outcomes later in life. In the present study, we aimed to investigate associations between birth velocity after with preterm infants. Fifty-six infants born &lt; 32 weeks of gestation or having a weight 1500 g were enrolled categorized into small for gestational age (SGA) appropriate (AGA) groups. Anthropometric parameters assessed school-age, Korean Wechsler...