A5065025555- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral Infections and Immunology Research
- Cytomegalovirus and herpesvirus research
- Peripheral Neuropathies and Disorders
- Hepatitis B Virus Studies
- Streptococcal Infections and Treatments
- Diphtheria, Corynebacterium, and Tetanus
- Virology and Viral Diseases
- Bacterial Identification and Susceptibility Testing
- Vaccine Coverage and Hesitancy
- Autoimmune and Inflammatory Disorders Research
- Parvovirus B19 Infection Studies
- Antimicrobial Resistance in Staphylococcus
- Pediatric health and respiratory diseases
- Urinary Tract Infections Management
- Clostridium difficile and Clostridium perfringens research
- Viral Infections and Vectors
- Neutropenia and Cancer Infections
Second Xiangya Hospital of Central South University
2025
Central South University
2025
Hubei Academy of Environmental Sciences
2025
Catholic University of Korea
2015-2024
Seoul St. Mary's Hospital
2014-2024
Henan Agricultural University
2024
Weatherford College
2024
Institut de Recherche Vaccinale
2014-2017
Sanofi (France)
2015
Yonsei University
2015
We developed multiplex polymerase chain reaction (PCR) to detect aac(6 ')/aph(2 "), aph(3 ')-IIIa, and ant(4 ')-Ia, the genes encoding most clinically relevant amino-glycoside modifying enzymes (AME), simultaneously, methicillin resistant gene, mecA, in Staphylococcus species. Clinical isolates of 45 S. aureus 47 coagulase negative staphylococci (CNS) from tertiary university hospitals were tested by conventional susceptibility testing, using agar dilution method PCR. Of a total 92 isolates,...
The recently discovered pneumococcal serotype 6C was created when the original wciN gene in 6A capsule locus naturally replaced with a new gene. Since loci of and 6B serotypes may differ by only one base pair wciP gene, it speculated that '6D' would be possible if were inserted into locus. Although pneumococci expressing 6D could produced laboratory, initial searches for natural isolates unsuccessful. However, we now report discovery two occurring from Korea have serological, genetic...
Although the proportion of Pseudomonas aeruginosa infections has reduced after introduction antibiotics with anti-pseudomonal effects, P. bacteremia still causes high mortality in immunocompromised patients. This study determined clinical characteristics and outcomes antibiotic susceptibilities strains isolated from febrile neutropenic patients.Thirty-one children adolescents underlying hematologic/oncologic disorders diagnosed between 2011 2016 were enrolled study. Their medical records...
Bacterial meningitis remains a serious cause of morbidity and mortality in childhood, despite the availability effective vaccines against Haemophilus influenzae type b (Hib) or Streptococcus pneumoniae. The purpose this study was to analyze data on bacterial cases Korea from 1996 through 2005. information all hospitalized bacteria-proven obtained 17 university hospitals nationwide. A total 402 were identified. Of these, 125 (29.9%) neonates. agalactiae most common bacteria responsible for 99...
The rate of urinary tract infections (UTIs) due to extended-spectrum β-lactamase (ESBL)-producing bacterial strains requiring carbapenem therapy has been increasing in children. This study was conducted evaluate the effect non-carbapenem antibiotic on childhood UTIs caused by ESBL-producing Escherichia coli or Klebsiella pneumoniae. Medical records children diagnosed with febrile E. K. pneumoniae between 2010 and 2014 were retrospectively reviewed. enrolled divided into two groups: ESBL...
BK virus (BKV)-associated hemorrhagic cystitis (BKV-HC) is a severe complication after hematopoietic stem cell transplantation (HSCT). Cidofovir (CDV) has emerged as an effective agent for the treatment of BKV nephropathy, but its use BKV-HC in pediatric HSCT recipients not yet been established standard therapy.We retrospectively investigated efficacy and safety CDV therapy patients with at single institution analyzed clinical management outcomes.From April 2009 to July 2011, 12 developed...
The purpose of this study was to identify the major etiological agents responsible for invasive bacterial infections in immunocompetent Korean children.We retrospectively surveyed children caused by eight pediatric bacteria, namely Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, agalactiae, pyogenes, Listeria monocytogenes, and Salmonella species that were diagnosed at 18 university hospitals from 1996 2005.A total 768 cases identified.S....
Background: Mycoplasma pneumoniae (MP) pneumonia is a self-limiting disease, but some patients complain of progressive pneumonia, despite appropriate antibiotic treatment.We aimed to introduce the role immune-modulators (corticosteroid and/or intravenous immunoglobulin, IVIG) treatment for childhood MP based on previous our experiences.Materials and Methods: A retrospective case series analysis 183 children with was performed.MP were diagnosed by two Immunoglobulin M (IgM) tests:...
A 9-valent human papillomavirus-6/11/16/18/31/33/45/52/58 (9vHPV) vaccine extends coverage to 5 next most common oncogenic types (31/33/45/52/58) in cervical cancer versus quadrivalent HPV (qHPV) vaccine. We describe efficacy, immunogenicity, and safety Asian participants (India, Hong Kong, South Korea, Japan, Taiwan, Thailand) from 2 international studies: a randomized, double-blinded, qHPV vaccine-controlled efficacy study (young women aged 16-26 years; NCT00543543; Study 001); an...
ABSTRACT Studies on the molecular epidemiologic characteristics of methicillin-resistant Staphylococcus aureus (MRSA) strains have demonstrated their genetic and geographical diversity. In addition, it has been reported that there are differences between community-associated (CA) health care-associated (HA) MRSA strains. Therefore, we investigated major CA isolates in South Korea compared them with those HA Distributions staphylococcal chromosome cassette mec (SCC ) types other features,...
Background: In South Korea, the one-dose varicella vaccine was included in National Immunization Program for children aged 12–15 months 2005, and coverage reached >95%. The impact of vaccination on herpes zoster (HZ) investigated, accounting demographic changes over time.Methods: We calculated crude age-sex standardized incidence rates (IRs) age-specific IRs HZ from 2003 to 2015, using Health Information Database including approximately 50 million Koreans. annual rate ratios (IRRs) were a...
Abstract Live varicella vaccines are known to provide robust immunity against zoster virus (VZV) infections. However, problems with viral attenuation have led pathogenic VZV vaccine strains causing varicella‐like rash and herpes in immunocompetent children after immunization. We report the first fatal case of infection caused by OKA/SK strain contained administrated as a booster shot an child, which has been independently developed from any currently available that OKA or MAV/06 based. The...
Anti-citrullinated peptide antibodies (ACPA)-negative (ACPA-) rheumatoid arthritis (RA) presents significant diagnostic and therapeutic challenges due to the absence of specific biomarkers, underscoring need elucidate its distinctive cellular metabolic profiles for more targeted interventions. Single-cell RNA sequencing data from peripheral blood mononuclear cells (PBMCs) synovial tissues patients with ACPA- ACPA+ RA, as well healthy controls, were analyzed. Immune cell populations...
This paper introduces the Large Memory Model (LM2), a decoder-only Transformer architecture enhanced with an auxiliary memory module that aims to address limitations of standard Transformers in multi-step reasoning, relational argumentation, and synthesizing information distributed over long contexts. The proposed LM2 incorporates acts as contextual representation repository, interacting input tokens via cross attention updating through gating mechanisms. To preserve general-purpose...
Water quality prediction serves as an important foundation for risk control and the proactive management of aquatic environment, Long Short-Term Memory (LSTM) network has gained recognition effective approach achieving high-precision water predictions. However, despite its potential, there is a significant gap in literature regarding confidence analysis accuracy underlying causes variability across different indicators basins. To address this gap, present study introduces novel evaluation...
Epstein-Barr virus (EBV)-associated gastric carcinomas have been reported from various regions of the world. appears to be pathogenetically related some carcinomas. To determine incidence EBV association with among Koreans, authors studied genome expression in 89 consecutive patients diagnosed at Catholic University Hospitals Seoul, Korea, using situ hybridization (ISH) for EBV-encoded small RNAs (EBERs), and immunohistochemistry latent membrane proteins (LMP) CD21 antigen on paraffin...
We investigated serotype distribution and antimicrobial resistance of pneumococcal carriage isolates from children after optional immunization with the 7-valent conjugate vaccine (PCV7) in Korea. From June 2009 to 2010, 205 (16.5%) were obtained 1,243 nasopharyngeal aspirates infants at Seoul National University Children's Hospital, Serotype was determined by Quellung reaction antibiotic susceptibility tested E-test. The results compared previous studies done pre-PCV7 period. In this study,...
This study was performed to compare the clinical characteristics and antibiotic susceptibilities of viridans streptococcal bacteremia (VSB) between febrile neutropenic adults children with hematologic malignancies.The consecutive medical records patients malignancies who were admitted Catholic Blood Marrow Transplantation Center April 2009 July 2012, subsequently diagnosed VSB reviewed retrospectively. A comparison made laboratory pediatric also cefepime susceptible or not VSB.A total 202...
Enterovirus 71, one of the enteroviruses that are responsible for both hand-foot-and-mouth disease and herpangina, can cause neural injury. During periods endemic spread hand-foot-andmouth caused by enterovirus CNS infections also frequently diagnosed may lead to increased complications from injury, as well death. We present results our epidemiologic research on clinical manifestations children with 71.The study group consisted 42 patients admitted infection 71 between April 2009 October at...
A new live attenuated Japanese encephalitis chimeric virus vaccine (JE-CV) has been developed based on innovative technology to give protection against JE with an improved immunogenicity and safety profile. In this phase 3, observer-blind study, 274 children aged 12-24 months were randomized 1:1 receive one dose of JE-CV (Group JE-CV) or the SA14-14-2 currently used vaccinate in Republic Korea SA14-14-2). neutralizing antibody titers assessed using PRNT50 before 28 days after vaccination....
Infant Pertussis and Household Transmission in KoreaA recent resurgence of pertussis has raised public health concerns even developed countries with high vaccination coverage.The aim this study was to describe the clinical characteristics infant pertussis, determine relative importance household transmission Korea.The multicenter prospectively conducted from January 2009 September 2011.We identified demographic data these patients performed diagnostic tests for their contacts.Twenty-one...
Haemophilus influenzae frequently colonizes the nasopharynx of children and adults, which can lead to a variety infections. We investigated H. carriage in 360 children, terms (1) prevalence strains with decreased susceptibility, (2) presence amino acid substitutions PBP3. One hundred twenty-three were isolated (34.2%, 123/360), 122 classified as nontypable (NTHi). Of these, β-lactamase-nonproducing ampicillin-susceptible accounted for 26.2%, β-lactamase-producing-ampicillin-resistant 9.0%,...