A5038837842- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Cytomegalovirus and herpesvirus research
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- Immune Cell Function and Interaction
- Bacterial Identification and Susceptibility Testing
- Blood disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- Family Support in Illness
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Neonatal Health and Biochemistry
- Pneumocystis jirovecii pneumonia detection and treatment
- Herpesvirus Infections and Treatments
- Erythrocyte Function and Pathophysiology
- Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Polyomavirus and related diseases
- Hematological disorders and diagnostics
- Family and Disability Support Research
- Hemoglobinopathies and Related Disorders
Catholic University of Korea
2016-2025
Seoul St. Mary's Hospital
2016-2025
Pham Ngoc Thach Hospital
2025
All India Institute of Medical Sciences
2021
Daejeon St. Mary's Hospital
2020
University of Birmingham
2018
Royal Marsden Hospital
2018
University of Colorado Denver
2018
Universidade Estadual de Campinas (UNICAMP)
2018
Children's Hospital Colorado
2018
Purpose Safe, effective treatments are needed for pediatric patients with chronic myeloid leukemia in phase (CML-CP). Dasatinib is approved treatment of adults and children CML-CP. A I study determined suitable dosing Philadelphia chromosome–positive (Ph+) leukemias. Methods CA180-226/NCT00777036 a II, open-label, nonrandomized prospective trial < 18 years age receiving dasatinib. There three cohorts: (1) imatinib-resistant/intolerant CML-CP, (2) CML accelerated/blast or Ph+ acute...
The aim of this study was to describe the mutational characteristics in Korean hereditary spherocytosis (HS) patients. Relevant literatures including genetically confirmed cases with well-documented clinical summaries and relevant information were also reviewed investigate gene- or domain-specific laboratory association. Twenty-five HS patients carried one heterozygous mutation ANK1 (n = 13) SPTB 12) but not SPTA1, SLC4A1, EPB42. Deleterious mutations frameshift, nonsense, splice site...
Some prospective studies showed that rabbit antithymocyte globulin was inferior to horse as first-line therapy for patients with severe aplastic anemia. We retrospectively analyzed the clinical outcome of 455 children anemia who received (n=297) or (n=158) combined cyclosporine between 1992 and 2010. The response rates were comparable groups at 3 months [46% (136/294) versus 42% (66/153), P=0.55] 6 [60% (178/292) 55% (87/143), P=1.0]. Using multivariate analysis, differences in preparations...
We identified principal genetic alterations in 97.1% (99/102) of patients with T-acute lymphoblastic leukemia (T-ALL) using integrative analyses, including massive parallel sequencing and multiplex ligation-dependent probe amplification (MLPA). A total 133 mutations were the following genes descending order: NOTCH1 (66.7%), FBXW7 (19.6%), PHF6 (15.7%), RUNX1 (12.7%), NRAS (10.8%), DNMT3A (9.8%). Copy number most frequently detected CDKN2B, CDKN2A, on 9p21.3 T-ALL (45.1%). Gene expression...
Although the proportion of Pseudomonas aeruginosa infections has reduced after introduction antibiotics with anti-pseudomonal effects, P. bacteremia still causes high mortality in immunocompromised patients. This study determined clinical characteristics and outcomes antibiotic susceptibilities strains isolated from febrile neutropenic patients.Thirty-one children adolescents underlying hematologic/oncologic disorders diagnosed between 2011 2016 were enrolled study. Their medical records...
BK virus (BKV)-associated hemorrhagic cystitis (BKV-HC) is a severe complication after hematopoietic stem cell transplantation (HSCT). Cidofovir (CDV) has emerged as an effective agent for the treatment of BKV nephropathy, but its use BKV-HC in pediatric HSCT recipients not yet been established standard therapy.We retrospectively investigated efficacy and safety CDV therapy patients with at single institution analyzed clinical management outcomes.From April 2009 to July 2011, 12 developed...
This study was performed to compare the clinical characteristics and antibiotic susceptibilities of viridans streptococcal bacteremia (VSB) between febrile neutropenic adults children with hematologic malignancies.The consecutive medical records patients malignancies who were admitted Catholic Blood Marrow Transplantation Center April 2009 July 2012, subsequently diagnosed VSB reviewed retrospectively. A comparison made laboratory pediatric also cefepime susceptible or not VSB.A total 202...
Background:The incidence of bacteremia caused by Gram-negative bacteria has increased recently in febrile neutropenic patients with the increase antibiotic-resistant bacterial infections.This study aimed to identify distribution causative and proportion diagnosed children. Materials Methods:The medical records children between 2010 2014 were retrospectively reviewed.The investigated compared yearly during period.The clinical impact infections was also determined.Results: A total 336 episodes...
Summary Inherited bone marrow failure syndromes (IBMFS) pose significant diagnostic challenges due to overlapping symptoms and variable expressivity, despite evolving genomic insights. The study aimed elucidate the landscape among 130 Korean patients with IBMFS. We conducted targeted next‐generation sequencing (NGS) clinical exome (CES) across cohort, complemented by whole genome (WGS) chromosomal microarray (CMA) in 12 47 cases, respectively, negative initial results. Notably, 50% ( n = 65)...
Abstract Background As neutropenia episodes in pediatric hemato-oncology often lead to sepsis and need antibiotics, monitoring resistance is crucial for empirical antibiotics choice. We analyzed antimicrobial susceptibility changes Enterobacterales from patients at Seoul St. Mary’s bone marrow (BMT) center. Data 2016-2020 2021-2023 were compared after shifting initial piperacillin-tazobactam (PIP-TZ) cefepime (CEF). Methods This was a retrospective cohort study of the BMT center hospital....
Background: Aplastic anemia (AA) is a rare bone marrow failure syndrome characterized by notably short telomere length, which associated with treatment responses. In this study, we measured lengths in Korean pediatric AA patients using flow-fluorescence situ hybridization (Flow-FISH) and explored their shortening relation to disease characteristics, genetic conditions patient outcomes. Methods: We analyzed peripheral blood samples from 75 101 healthy controls. Telomere were Flow-FISH,...
Neurocognitive sequelae are common late complications in childhood cancer survivors (CCS), impacting quality of life, yet no validated Korean tool exists to screen neurocognitive function effectively. CCS (N = 638) and their siblings 218) were included from a cohort study at three major hospitals South Korea. To determine the underlying structure K-NCQ, exploratory factor analysis confirmatory performed. Pearson's correlations used evaluate concurrent convergent validity. We also explored...
<title>Abstract</title> Purpose Gaucher disease (GD) is an autosomal recessive condition caused by insufficient glucocerebrosidase activity. The Earlier Diagnosis Consensus (GED-C) initiative created a point-scoring system (PSS) to facilitate the early identification of GD based on significant indicators and covariables. This study aimed evaluate applicability utility GED-C PSS in pediatric young adult patients Korea. Results included both retrospective analysis prospective recruitment....
Scrub typhus is a rickettsial disease, caused by Orientia tsutsugamushi, which transmitted via the bite of chigger. This disease one most important infectious diseases in Asia-Pacific area; however, severe infant case has not yet been reported. Here, we present an 8-month-old boy with scrub accompanied hemophagocytic lymphohistiocytosis (HLH). His rapid course was complicated acute respiratory distress syndrome (ARDS), status epilepticus and disseminated intravascular coagulation (DIC). He...
Purpose Dexrazoxane has been used as an effective cardioprotector against anthracycline cardiotoxicity. This study intended to analyze cardioprotective efficacy and secondary malignancy development, elucidate risk factors for malignancies in dexrazoxane-treated pediatric patients. Materials Methods Data was collected from 15 hospitals Korea. Patients who received any anthracyclines, completed treatment without stem cell transplantation were included. For evaluation, the incidence of cardiac...
Objective To evaluate the added value of diffusion weighted image (DWI) including volumetric analysis to standard magnetic resonance imaging (MRI) for predicting poor responders neoadjuvant chemotherapy in patients with osteosarcoma at 3-Tesla. Methods 3-Tesla Standard MRI and DWI 17 were reviewed by two independent readers. was using a five-level-confidence score. Two-dimensional (2D) apparent coefficient (ADC)mean 2D ADCminimum measured from single-section region interest. An ADC histogram...
Recent studies indicate 70-80% event-free survival (EFS) for pediatric acute lymphoblastic leukemia (ALL). In this study, we report the outcome of 295 children and adolescents treated at our institution, with stratification into four risk groups, omission cranial irradiation in all patients.Patients were diagnosed from January 2005 to December 2011 classified as low, standard, high, very high groups. A delayed intensification phase was given twice None patients received central nervous...
Jaewoong Lee, M.D., Joonhong Park, Ph.D., Hayoung Choi, B.S., Jiyeon Kim, Ahlm Kwon, Woori Jang, Hyojin Chae, Myungshin Yonggoo Jae Wook Nack-Gyun Chung, and Bin Cho, Ph.D.. Ann Lab Med 2017;37:108-16. https://doi.org/10.3343/alm.2017.37.2.108
We evaluated the results of a novel conditioning regimen reduced dose cyclophosphamide (Cy, 25 mg/kg for four days), fludarabine (Flu, 30 mg/m(2) and rabbit ATG (2.5 three days) allogeneic transplant children with SAA, implemented since January 2009. Overall, 23 patients were treated this (16 male, seven female), including 10 diagnosed VSAA. Donors included eight-MSD 15 UD (five-matched UD, mismatched UD). All showed neutrophil platelet engraftment. Cumulative incidence acute (grade 2 or...
Invasive pulmonary aspergillosis (IPA) is the most common invasive fungal disease in immunocompromised patients, and it has a 30 % mortality rate despite appropriate antifungal therapy. This retrospective study was performed to determine risk factors for children with IPA.Medical records of 45 probable/proven IPA cases diagnosed hematologic/oncologic diseases were reviewed. Selected divided into survival (n = 30) fatality 15) groups based on at 12 weeks after Clinical characteristics serum...
Pulmonary Aspergillosis in Korean Children with Hematologic/Oncologic DiseasesInvasive pulmonary aspergillosis (IPA) is the most frequent form of invasive fungal diseases immunocompromised patients.However, there are only a few studies on IPA children Korea.This study was designed to characterize hematologic/oncologic diseases.Medical records receiving antifungal therapy were reviewed.The enrolled divided into group (proven and probable IPA) non-IPA group, clinical characteristics prognosis...