A5103063533- Autoimmune and Inflammatory Disorders Research
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Viral gastroenteritis research and epidemiology
- Streptococcal Infections and Treatments
- Pediatric health and respiratory diseases
- Ocular Diseases and Behçet’s Syndrome
- Vaccine Coverage and Hesitancy
- Neonatal and Maternal Infections
- Adolescent and Pediatric Healthcare
- Pneumocystis jirovecii pneumonia detection and treatment
- Influenza Virus Research Studies
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Connective tissue disorders research
- Parvovirus B19 Infection Studies
- Inflammasome and immune disorders
- COVID-19 Clinical Research Studies
- Kawasaki Disease and Coronary Complications
- Hepatitis Viruses Studies and Epidemiology
- Herpesvirus Infections and Treatments
Myongji Hospital
2021-2023
Hanyang University
2022-2023
Seoul National University
2023
Hallym University Sacred Heart Hospital
2012-2022
Hallym University
2008-2021
Inje University Ilsan Paik Hospital
2019
Hallym University Medical Center
2010-2017
Animal and Plant Quarantine Agency
2015
Hangang Sacred Heart Hospital
2010-2012
Ōtani University
2012
ChAdOx1 and BNT162b2 vaccines are currently commonly used against coronavirus disease 2019 worldwide. Our study was designed to determine the serostatus relative levels of anti-S neutralizing antibodies in patients who were administered either or vaccine. In addition, we investigated whether antibody response each vaccine differed according sex age.Healthcare workers (HCWs) at a general hospital vaccinated with two doses invited participate this prospective cohort study. Blood samples HCWs...
Bacterial meningitis remains a serious cause of morbidity and mortality in childhood, despite the availability effective vaccines against Haemophilus influenzae type b (Hib) or Streptococcus pneumoniae. The purpose this study was to analyze data on bacterial cases Korea from 1996 through 2005. information all hospitalized bacteria-proven obtained 17 university hospitals nationwide. A total 402 were identified. Of these, 125 (29.9%) neonates. agalactiae most common bacteria responsible for 99...
Abstract Viral IL-10 (vIL-10) and soluble TNF receptor (sTNFR) are anti-inflammatory proteins that can suppress collagen-induced arthritis (CIA). These related have shown efficacy in the treatment of human rheumatoid arthritis; however, neither alone is able to completely disease. Furthermore, they short half-lives, necessitating frequent administration. To determine ability these act synergistically following gene transfer, was induced DBA/1 male mice by immunization with type II collagen...
The purpose of this study was to identify the major etiological agents responsible for invasive bacterial infections in immunocompetent Korean children.We retrospectively surveyed children caused by eight pediatric bacteria, namely Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, agalactiae, pyogenes, Listeria monocytogenes, and Salmonella species that were diagnosed at 18 university hospitals from 1996 2005.A total 768 cases identified.S....
The efficacy and safety of the BNT162b2 vaccine are known, but antibodies expected to decrease over time after vaccination. We collected blood samples from 104 fully vaccinated health care workers at 3 5 weeks first vaccination 4 months second Antibody titers neutralizing were measured. In our study, both antibody increased significantly decreased rapidly Additionally, results showed a significant regardless gender or age. Further studies needed help determine interval SARS-CoV-2 vaccinations.
Background:The coronavirus disease-2019 (COVID-19) pandemic has contributed to the change in epidemiology of many infectious diseases.This study aimed establish pre-pandemic pediatric invasive bacterial infection (IBI).Methods: A retrospective multicenter-based surveillance for IBIs been maintained from 1996 2020 Korea.IBIs caused by eight bacteria (Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, Streptococcus agalactiae, pyogenes, Listeria...
Rotavirus (RV) infection is the primary cause for childhood gastroenteritis worldwide. In Korea, RV most common among children less than 5 y of age. This post-licensure study was conducted to further evaluate vaccine (RIX4414) provide additional local clinical data Korean Food and Drug Association. Healthy infants aged 6–12 weeks were enrolled receive two doses either RIX4414 or placebo as per 0, 1–2 mo schedule. Blood samples collected before dose-1 one month post-dose-2 RIX4414/placebo...
Background: Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative organisms Korea.Methods: A total of 947 cases from 25 university hospitals identified 2006 2010 as a continuance previous 10-year period study 1996 2005.Results: Escherichia coli (41.3%),Streptococcus agalactiae (27.7%), and Staphylococcus aureus (27.1%) the most common pathogens infants < 3 months age.S. was prevalent cause meningitis pneumonia E. major...
Abstract Background: Group B streptococcus (GBS) is the most common cause of invasive neonatal infections in developed countries. The incidence early‐onset GBS disease Korea known to be much lower than that other countries; however has been frequently reported recent years Korea. This retrospective study sought determine current status and clinical presentation Methods: From January 1996 through December 2005, cases ( n = 157) diagnosed blood, cerebrospinal fluid, or sterile body fluids...
목적: 국내 로타바이러스 백신 도입 전후로 8년간 입원한 위장관염의 역학 및 임상 양상의 변화를 파악하고자 하였고, 최근 2년간 입원 환자를 대상으로 예방접종의 효과에 대하여 분석하였다. 방법: 2006년 1월부터 2013년 12월까지 급성 위장관염으로 5세 미만의 5,697명의 환아 중 항원 검사에 양성을 보인 1,165명의 연도 계절별추이를 그리고 2011년 12월부터 환아들 460명을 설문조사를 실시하여 접종 여부, 횟수, 증상 등에 파악하였고, 이들 항원검사에서 양성이 확인된 124명을 예방접종 시행 여부에 따른 검사실 결과를 비교 결과: 1) 연령별 분포는 2세미만의 환아가 전체의 64.5%를 차지하였다. 연도별 위장관염 발생 수는 2010년부터 급격히 감소하였다. 월별 2008년까지는 12월에 발생이 증가하기 시작하여 1-2월에 정점을 이루었으나, 2010년 이후로는 3-4월에 이루는 양상으로, 이후 로타바이러스의 활동의 시작, 계절적 정점이 늦춰지는 양상을...
This study was performed to measure early changes in the serotype distribution of pneumococci isolated from children with invasive disease during 3-year period following introduction 10- and 13-valent pneumococcal conjugate vaccines (PCVs) Korea. From January 2011 December 2013 at 25 hospitals located throughout Korea, were among who had (IPD). Serotypes determined using Quellung reaction, change analyzed. Seventy-five cases IPD included. Eighty percent patients aged 3-59 months, 32% a...
This study was conducted to determine differences in adverse events associated with the first and second doses of BNT162b2 coronavirus disease 2019 vaccine based on age sex recipients.An online survey post-vaccination healthcare workers from March 2021 April 2021. The types events, including severity, onset time, duration symptoms, how were dealt by patient analyzed sex. profiles compared after vaccination doses.Among 131 participants who participated out 208 recipients, 43 80 recipients...
To assess the safety and immunogenicity of a meningococcal polysaccharide diphtheria toxoid conjugate vaccine (MenACYW-D) in Korean population.This was phase III, blind-observer, controlled study which participants aged 11-55 years were randomized (2:1 ratio) to single dose MenACYW-D or tetanus/diphtheria/acellular pertussis (Tdap) vaccine. Outcomes included rates seroconversion against all serogroups (≥4-fold increase antibody titer from pre-vaccination), geometric mean titers (GMTs) at...
The systematic approach to pharmacologic treatment is typically begin with the safest, simplest, and most conservative measures. It has been realized that more rapidly inflammation under control, less likely it there will be permanent sequelae. Nonsteroidal anti-inflammatory drugs (NSAIDs) are mainstay of initial for inflammation. In addition, slow-acting antirheumatic (SAARDs) disease-modifying (DMARDs) have efficacy action in children chronic arthritis. New therapeutic modalities...
Considerable interest has been generated by the observation that adenovirus-mediated gene delivery to a single arthritic joint results in suppression of arthritis distal joints associated with presence small numbers transduced cells joints. It proposed this is mediated trafficking from injected There are, however, alternative explanations have not explored, including possibility transgene protein or infectious virions circulate sites. To investigate these possibilities,...
Thanatophoric dysplasia (TD) is a short-limb neonatal dwarfism syndrome that usually lethal in the perinatal period. It characterized by shortening of limbs, severely small thorax, large head with prominent forehead, macrocephaly, curved femur, and flattened vertebral bodies. These malformations result from mutation fibroblast growth factor receptor 3 (FGFR-3) gene which located on short arm chromosome 4. A definite diagnosis should be established molecular genetic analysis to find out...
Understanding the population genetics of pneumococci will allow detection changes in prevalence circulating genotypes and evidence for capsular switching. We aimed to analyze genetic structure invasive pneumococcal isolates obtained from children before after use conjugate vaccines (PCVs) Korea. A total 285 were analyzed using serotyping, multilocus sequence typing, antimicrobial susceptibility testing. classified isolation year pre-PCV7 (1995–2003; n = 70), post-PCV7 (2004–2010; 142),...
Macrophage activation syndrome (MAS) is a rare and potentially fatal complication of rheumatic disorders in children.We describe 13-month-old boy whom MAS developed as systemic juvenile rheumatoid arthritis (S-JRA).He suffered from fever generalized rash followed by multiple joints swelling for four months before admission.Physical examination revealed cervical lymphadenopathy hepatosplenomegaly.Laboratory findings were: abnormal liver enzymes, increased triglyceride ferritin levels,...
Objective Previous classification systems for juvenile idiopathic arthritis (JIA) were based on the number of joints involved and did not categorize homogenous disease entities. Therefore, JIA patients reclassified retrospectively by applying rheumatoid factor (RF) antinuclear antibody (ANA), which have been proven to constitute a entity. Methods The medical records investigated into six categories using new provisional classification. nomenclature was Dr. Martini's proposal in 23rd European...
Chronic arthritis, the most common chronic rheumatic disease of childhood, is one frequent illness children and an important cause short long term disability. It not a single disease, but group related, genetically heterogeneous, phenotypically diverse immunoinflammatory disorders that affect joints other structures, possibly activated by contact with external antigens. Since its introduction in 1994, Juvenile Idiopathic Arthritis (JIA) has largely supplanted terms Rheumatoid Arthritis....
Variant Klinefelter syndrome with 48,XXXY/46,XY mosaicism has been rarely reported, and its phenotypic features, compared those of the classic type, have not well delineated. We describe a newborn baby abnormalities, including cleft palate low-set ears. The cytogenetic analysis peripheral blood lymphocytes showed karyotype 48,XXXY[36]/46,XY[4]. To best our knowledge, this is first case in which was related to congenital anomaly palate. This underscores that should be mandatory workup for...
Objective This study examined the prevalence of low-bone mineral density (BMD) and its associated factors in Korean children adolescents with juvenile idiopathic arthritis (JIA). Methods Thirty-nine patients JIA were included this cross-sectional study. The for their bone age (BA) (BMD). BMD was measured using dual-energy X-ray absorptiometry on lumbar spine. Each value converted to a Z-score by comparing reference values healthy control group terms sex each patient, which same device. A...
Invasive bacterial infection (IBI) causes a significant burden in infants. In this study, we analyzed changes epidemiology of IBI among infants Korea.A retrospective multicenter-based surveillance for IBIs <3 months age was performed during 2006-2020. Cases were classified as an early-onset disease (EOD) (0-6 days) or late-onset (LOD) (7-89 days). The temporal trend change proportion pathogens analyzed.Among 1545 cases, the median 28 days (IQR: 12, 53) and EOD accounted 17.7%. Among...