A5022084009- Streptococcal Infections and Treatments
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Infective Endocarditis Diagnosis and Management
- Emergency and Acute Care Studies
- Long-Term Effects of COVID-19
- Antimicrobial Resistance in Staphylococcus
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Antibiotic Resistance in Bacteria
- Neonatal and Maternal Infections
- Viral Infections and Immunology Research
- Toxoplasma gondii Research Studies
- Enterobacteriaceae and Cronobacter Research
- Microbial Metabolism and Applications
- Pericarditis and Cardiac Tamponade
- Otolaryngology and Infectious Diseases
- Bacterial Infections and Vaccines
- Muscle and Compartmental Disorders
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Vaccine Coverage and Hesitancy
Seoul National University Children's Hospital
2020-2025
Seoul National University
2020-2025
New Generation University College
2022
Seoul National University Hospital
2020
Data on the clinical characteristics of pediatric patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant infection are limited. We aimed to evaluate features and outcomes children SARS-CoV-2 before after omicron dominance in Korea.A multicenter retrospective cohort study was conducted hospitalized aged ≤ 18 years laboratory-confirmed at five university hospitals South Korea. The periods were divided into delta (from August 23, 2021 January 2, 2022) 30 March 31,...
Background: The COVID-19 pandemic’s transition to an endemic phase emphasizes the importance of vaccination. Despite initial strong immunogenicity, waning vaccine-induced immunity requires further investigation. Therefore, this study evaluated immunogenicity BNT162b2 vaccine in adolescents, focusing on spike-specific and neutralizing antibody kinetics following primary booster vaccinations as well impact breakthrough infections. Methods: This observational included 157 adolescents 12–17...
Parainfluenza virus type 3 (PIV3) and respiratory syncytial (RSV) B epidemics occurred in South Korea late 2021. We investigated epidemiological changes of PIV3 RSV infections Korean children before during the coronavirus disease 2019 (COVID-19) pandemic.In this multicenter retrospective study, we enrolled patients aged less than 19 years with or infection four university hospitals from January 2018 to 2022. Demographic clinical data were extracted subject's medical records analyzed for each...
Korean health authority plans to vaccinate adolescents against coronavirus disease 2019 (COVID-19) starting high school seniors during the summer vacation of 2021. However, myocarditis/pericarditis following COVID-19 vaccine has been reported recently in and young adults. This study was performed answer urgent questions about basic epidemiology clinical course hospitalized patients prior introduction vaccines pediatric population.A retrospective medical record analysis including frequency,...
Background:The coronavirus disease-2019 (COVID-19) pandemic has contributed to the change in epidemiology of many infectious diseases.This study aimed establish pre-pandemic pediatric invasive bacterial infection (IBI).Methods: A retrospective multicenter-based surveillance for IBIs been maintained from 1996 2020 Korea.IBIs caused by eight bacteria (Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, Streptococcus agalactiae, pyogenes, Listeria...
Omicron, a recent variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently globally dominating. We reviewed the etiology and epidemiology croup over an approximately 5-year period, with emphasis on dominance Omicron variant. Children less than 5 years age seen in emergency department diagnosis from two large national tertiary hospitals were collected for period January 2018 through March 2022. Viral etiologies patients compared surveillance data upon circulating...
The risk of severe outcomes with acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delta variant remains low in children and adolescents, but less is known about its effect on the SARS-CoV-2-naïve population. This study evaluated clinical manifestations factors for moderate-to-critical disease 2019 (COVID-19) mostly adolescents 2021.This multicenter retrospective included patients aged 0-18 years who were hospitalized COVID-19 at 8 referring hospitals South Korea during...
There have been many epidemiologic studies on community-acquired pneumonia (CAP) among children, most of which had substantial limitations. This study investigated the etiologic distribution and clinical characteristics CAP in Korean children for 5 years before coronavirus disease 2019 (COVID-19) pandemic.A retrospective analysis hospitalized at 4 referral hospitals during 2015-2020 was performed. Cases bronchiolitis suspected or pulmonary infiltration not evident chest radiography (CXR)...
ObjectivesIn Korea, the National Immunization Program provided trivalent inactivated influenza vaccines (IIV3) to all children aged 6–59 months during 2017–2018 season. In this study, we aimed evaluate vaccine effectiveness (VE) of IIV3 in season.MethodsChildren who were tested for their acute respiratory illness four hospitals season included. We estimated VE by test-negative case-control design based on rapid diagnostic test (RIDT) or reverse transcription polymerase chain reaction...
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been acknowledged as an effective mean of preventing infection and hospitalization. However, the emergence highly transmissible SARS-CoV-2 variants concern (VOCs) led to substantial increase in infections among children adolescents. Vaccine-induced immunity longevity have not well defined this population. Therefore, we aimed analyze humoral cellular immune responses ancestral after two shots BNT162b2 vaccine...
Objective: Changes in the epidemiology, clinical manifestations, and outcomes of infective endocarditis (IE) have been reported recent years. This study was performed to analyze changing trends etiology IE children South Korea. Study design: A retrospective with conducted from 2 hospitals Korea 2004 2019. defined according Modified Duke criteria. We analyzed outcome 96 cases compared that during 1987–1997, as described a previous study. Results: total 89 satisfied modified The median age 9.5...
Invasive bacterial infection (IBI) causes a significant burden in infants. In this study, we analyzed changes epidemiology of IBI among infants Korea.A retrospective multicenter-based surveillance for IBIs <3 months age was performed during 2006-2020. Cases were classified as an early-onset disease (EOD) (0-6 days) or late-onset (LOD) (7-89 days). The temporal trend change proportion pathogens analyzed.Among 1545 cases, the median 28 days (IQR: 12, 53) and EOD accounted 17.7%. Among...
Cytomegalovirus (CMV) disease is rare in children who receive anticancer chemotherapy and have no history of stem cell transplantation (SCT).We report a case CMV retinitis that developed during maintenance for acute leukemia.A 7-year-old boy decreased visual acuity persistent pancytopenia chemotherapy.Laboratory investigations initially showed significant antigenemia (51 positive cells/200,000 leukocytes); however, antiviral therapy was not deemed necessary this patient had SCT.CMV worsened...
We aimed to investigate the microbiologic characteristics of nonbaumannii Acinetobacter calcoaceticus-baumannii (NB-ACB) complex isolated from Korean children. Blood isolates ACB complexes were collected in three referring hospitals during 2015-2020. Genomic DNA was sequenced using a Nanopore sequencing platform, and assembled contigs used for antimicrobial resistance (AMR) gene detection. Of 55 complexes, 18 (32.7%) identified as NB-ACB complexes: A. nosocomialis (n=9), pittii (n=7),...