A5082428721- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
- COVID-19 Impact on Reproduction
- SARS-CoV-2 detection and testing
- Reproductive System and Pregnancy
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Immunotherapy and Immune Responses
- Animal Virus Infections Studies
Korea National Institute of Health
2023-2025
Korea Disease Control and Prevention Agency
2022-2024
Background: The COVID-19 pandemic’s transition to an endemic phase emphasizes the importance of vaccination. Despite initial strong immunogenicity, waning vaccine-induced immunity requires further investigation. Therefore, this study evaluated immunogenicity BNT162b2 vaccine in adolescents, focusing on spike-specific and neutralizing antibody kinetics following primary booster vaccinations as well impact breakthrough infections. Methods: This observational included 157 adolescents 12–17...
Concerns about the effectiveness of current vaccines against rapidly spreading severe acute respiratory syndrome-coronavirus-2 omicron (B.1.1.529) variant are increasing. This study aimed to assess neutralizing antibody activity wild-type (BetaCoV/Korea/KCDC03/2020), delta, and variants after full primary booster vaccinations with BNT162b2. A plaque reduction neutralization test was employed determine 50% dilution (ND
Tixagevimab/cilgavimab is a monoclonal antibody used to prevent coronavirus disease 2019 among immunocompromised hosts and maintained neutralizing activity against early omicron variants. Omicron BN.1 became dominant circulating strain in Korea 2023, but its susceptibility tixagevimab/cilgavimab unclear. We conducted plaque reduction neutralization test (PRNT) prospective cohort (14 patients 30 specimens). PRNT was for one- three-months after administration the average ND50 of each point...
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been acknowledged as an effective mean of preventing infection and hospitalization. However, the emergence highly transmissible SARS-CoV-2 variants concern (VOCs) led to substantial increase in infections among children adolescents. Vaccine-induced immunity longevity have not well defined this population. Therefore, we aimed analyze humoral cellular immune responses ancestral after two shots BNT162b2 vaccine...
Introduction Although the safety and effectiveness of COVID-19 vaccination during pregnancy have been proven, there is still little data explaining neonatal outcomes maternal pre-pregnancy vaccination. Methods Here, we investigated impact SARS-CoV-2 infection on maternal-neonate immune response in a cohort study involving 141 pregnant individuals, defined importance timing for its effectiveness. Results discussion Our indicate that vertically transferred hybrid immunity provides...
Background: Controversy remains regarding the safety of COVID-19 vaccination during pregnancy. Here, we investigated impact and SARS-CoV-2 infection on maternal-neonate immune response in a cohort study involving pregnant individuals, defined importance maternal timing for its effectiveness.Methods: We divided 141 participants into groups according to time SARS CoV-2 infection. Maternal blood samples were collected pregnancy at delivery. Newborn from cord taken after Blood sera used PRNT...
The immunogenicity of a heterologous vaccination regimen consisting ChAdOx1 nCoV-19 (a chimpanzee adenovirus-vectored vaccine) followed by mRNA-1273 lipid-nanoparticle-encapsulated mRNA-based against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), specifically the omicron variant (B.1.1.529), is poorly studied. aim this study was to evaluate neutralizing antibody activity and prime-boost wild-type (BetaCoV/Korea/KCDC03/2020), alpha, beta, gamma, delta, variants SARS-CoV-2 in...