A5036053743- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Antifungal resistance and susceptibility
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Korean Urban and Social Studies
- Long-Term Effects of COVID-19
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 detection and testing
- Healthcare Education and Workforce Issues
- Heparin-Induced Thrombocytopenia and Thrombosis
- Infections and bacterial resistance
- Education and Learning Interventions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neutropenia and Cancer Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Parathyroid Disorders and Treatments
- Enterobacteriaceae and Cronobacter Research
- Sepsis Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Fungal Infections and Studies
- Toxoplasma gondii Research Studies
- Intensive Care Unit Cognitive Disorders
- Abdominal Trauma and Injuries
Samsung Medical Center
2020-2025
Sungkyunkwan University
2019-2024
Chiba University
2011-2023
Zhengzhou University
2021-2023
Soongsil University
2021
Shanghai First People's Hospital
2020
The effects of corticosteroid use on the reactogenicity and immunogenicity ChAdOx1 nCoV-19 (ChAd) vaccine were evaluated. Healthcare workers (HCWs) who took low-dose agents around time first dose ChAd (ChAdPd group) recruited compared with those (ChAd BNT162b2 vaccination (BNT HCWs without exposure. was measured three weeks after using quantitative anti-SARS-CoV-2 spike protein (S) antibody electrochemiluminescence immunoassay interferon gamma (IFN-γ) release assay. A total 67 comprising 24...
Diminished immune response to coronavirus disease 2019 (COVID-19) vaccines and breakthrough infection (BI) is a major concern for solid organ transplant recipients. Humoral cellular responses of kidney (KT) recipients after third COVID-19 vaccination were investigated compared matched health care workers. Anti-severe acute respiratory syndrome 2 spike protein antibody severe specific interferon-gamma releasing assay (IGRA) assessed. A total 38 KT recipients, including 20 BI 18 noninfection,...
Abstract Background Rifabutin (Rfb) is commonly administered instead of rifampicin for the treatment tuberculosis (TB) in SOTR to avoid substantial drug interaction rifampin. However, evidence its efficacy scarce. Methods We conducted a retrospective, case-control study at Samsung Medical Center. The group included aged ≥ 18 years who were diagnosed with culture-positive pulmonary TB and treated anti-TB medications that both isoniazid (INH) Rfb > 80% total duration. Patients...
Abstract Background A combination of anti-staphylococcal penicillin or cefazolin and gentamicin has been recommended as an empirical treatment regimen for native valve late prosthetic infective endocarditis (NV/LPVIE), while the recent European Society Cardiology Guidelines proposed ampicillin plus ceftriaxone (AMP+CRO) option. However, clinical data supporting either are scarce. Risk factors composite outcome in a Cox proportional hazard model with overlap weighting. Methods retrospective...
High concentration of mold spores in inhaled air is an important risk factor for invasive infections. COVID‐19 (coronavirus disease 2019)‐associated pulmonary aspergillosis (CAPA) a serious complication severe COVID‐19. To investigate the distribution negative‐pressure isolation wards and its potential association with CAPA incidence, we conducted microbiological sampling retrospectively analyzed cases tertiary care hospital Korea during pandemic. Air was January 2022 at multiple sites four...
The effect of tixagevimab/cilgavimab (Evusheld™; AstraZeneca, UK) should be evaluated in the context concurrent outbreak situations. For serologic investigation during BA.5 period, sera immunocompromised (IC) hosts sampled before and one month after administration those healthcare workers (HCWs) a 3rd shot COVID-19 vaccines, five months BA.1/BA.2 breakthrough infection (BI), BI were investigated. Semi-quantitative anti-spike protein antibody (Sab) test plaque reduction neutralizing (PRNT)...
ABSTRACT The coronavirus disease 2019 pandemic persisted for 3 years and is now transitioning to endemicity. We illustrated the change in group immunity induced by vaccination (monovalent vaccines) breakthrough infections (BIs) a healthcare worker (HCW) cohort. Five sampling points were analyzed: before third dose 1, 3, 5, 8 months after vaccination. last two corresponded roughly 1 4 omicron BA.1/BA.2 BI. A semi-quantitative anti-spike binding antibody (Sab) assay plaque reduction...
The impact of nirmatrelvir/ritonavir treatment on shedding viable virus in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. A prospective cohort study evaluating mildly ill COVID-19 patients was conducted. Virologic responses were compared between nirmatrelvir/ritonavir-treatment and supportive care groups. Risk factors relevant clinical for investigated. total 80 enrolled 222 sputum specimens collected. Ten dropped during follow-up, 33 the 37 groups compared. median...
Posaconazole (PSC) delayed-release tablet prophylaxis is the standard of care for preventing invasive fungal infection (IFI) in patients with acute myeloid leukemia undergoing myelosuppressive chemotherapy. The clinical features, risk factors, and PSC profiles breakthrough IFI (bIFI) receiving were investigated. A single-center retrospective cohort study was conducted, including adult malignancy who received prophylactic tablets while chemotherapy from June 2016 to 2021. Logistic regression...
The coronavirus disease 2019 (COVID-19) pandemic has caused the death of thousands patients worldwide. Although age is known to be a risk factor for morbidity and mortality in COVID-19 patients, critical illness or occurring even younger group as epidemic spreads. In early 2022, omicron became dominant variant virus South Korea, proceeded on large scale. Accordingly, this study aimed determine whether young adults (aged ≤ 50 years) with infection during period had different characteristics...
Real-world experience with tocilizumab in combination dexamethasone patients severe coronavirus disease (COVID-19) needs to be investigated.A retrospective cohort study was conducted evaluate the effect of severity-adjusted dosing for COVID-19 from August 2020 2021. The primary endpoint 30-day clinical recovery, which defined as no oxygen requirement or referral after recovery.A total 66 were evaluated, including 33 (Dexa) group and plus (DexaToci) group. DexaToci showed a statistically...
With the introduction of ceftazidime-avibactam worldwide, antimicrobial activity new β-lactam/β-lactamase inhibitors (BL/BLIs) needs to be investigated. From January 2020 June 2023, Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacterales were collected. a broth microdilution test BL/BLIs, cross-activity with nine combinations BLs and BLIs dose-escalation titration for non-susceptible isolates conducted investigate inhibitory activities BLIs. A total 188 was collected most...
Tixagevimab/cilgavimab is a monoclonal antibody used to prevent coronavirus disease 2019 among immunocompromised hosts and maintained neutralizing activity against early omicron variants. Omicron BN.1 became dominant circulating strain in Korea 2023, but its susceptibility tixagevimab/cilgavimab unclear. We conducted plaque reduction neutralization test (PRNT) prospective cohort (14 patients 30 specimens). PRNT was for one- three-months after administration the average ND50 of each point...
Abstract Despite a high vaccination rate, the COVID‐19 pandemic continues with immune‐evading Omicron variants. The success of additional antigenic stimulation through breakthrough infection (BI) and updated in overcoming imprinting needs to be determined. Participants long‐term follow‐up cohort healthcare worker (HCW) vaccinee were categorized according their infection/vaccination status. Anti‐SARS‐CoV‐2 spike/nucleocapsid protein antibodies measured, plaque reduction neutralization tests...
ABSTRACT In October 2022, we experienced a significant increase in samples showing high galactomannan (GM) indexes ranging from 6.22 to 10.58, as determined by the Platelia Aspergillus antigen immunoassay, also known GM test. After reviewing medical records of nine antigenemia cases that did not show evidence invasive aspergillosis, found these patients had received total parenteral nutrition (TPN) products same manufacturer, whose supplier glucose component recently changed. The TPN...
In this study, we describe an Enterobacter ludwigii clinical isolate that is resistant to both carbapenems and colistin in South Korea. Antimicrobial susceptibility testing revealed E. CRE2104-31 was non-susceptible all tested antibiotics except fosfomycin. Whole genome sequencing identified a 323-kbp IncHI2 plasmid, pCRE2104-31a, co-harboring mcr-9.1 blaIMP-1. comparison with other full plasmids, pCRE2104-31a exhibited the closest similarity plasmid from Klebsiella pneumoniae strain CNR48...
Purpose The purpose of this study was to verify their effectiveness as we develop and apply worksheets for improving life skills resilience collegiate Taekwondo athletes. Methods went through three stages: developing, applying, evaluating. In the developing stage, literature review, expert meeting, pilot test (n=25) were conducted worksheets. applying 37 athletes participated in program using Data collected by survey in-depth interview. evaluating paired t-test, word cloud analysis,...
Abstract We report a case of tuberculosis (TB) meningitis after allogeneic hematopoietic stem cell transplantation (HSCT) for relapsed acute myeloid leukemia. The patient was 52‐year‐old woman who had leukemia with remission duration 7 months, and she received re‐induction consolidation, HSCT. After 4 days engraftment, headache fever cerebrospinal fluid (CSF) analysis presented increased intracerebral pressure, white blood counts dominant neutrophils, elevated glucose protein level. Brain...
The purpose of this study was the psychological ownership commercial sports facility workers to investigate impact organizational commitment and innovative work behavior. 2013 survey using a purposive sampling method, 300 questionnaires are distributed by metropolitan facilities were utilized in except insincere response 15 total 285 questionnaires., Data Processing Method, descriptive statistics frequency analysis exploratory factor SPSS 18.0, AMOS 18.0 confirmatory structural equation...
Abstract Background Light chain amyloidosis, characterized by amyloid fibril deposition in multiple organs, often leads to progression end-stage kidney disease. This study aimed identify predictors of survival patients with focusing on hematologic and response. Methods retrospective included 138 diagnosed amyloidosis between 2011 2019. Palladini et al.'s criteria were applied for stage response, the 2012 International Society Amyloidosis Results Overall, 17 (12.3%) progressed Multivariate...
Background: We aimed to identify the risk factors for impaired cellular and humoral immunity after three doses of SARS-CoV-2 vaccine. Methods: Six months third vaccine dose, T-cell was evaluated using interferon-gamma release assays (IGRAs) in 60 healthy 139 immunocompromised (IC) individuals, including patients with hematologic malignancy (HM), solid (SM), rheumatic disease (RD), kidney transplantation (KT). Neutralizing antibody titers were measured plaque reduction neutralization test...
Abstract Aims The diagnostic difficulty of heart failure with preserved ejection fraction (HFpEF) is related to the fact that many patients develop abnormal hemodynamics only during exercise. Exercise stress echocardiography a first-line test unmask such abnormalities, but exercise protocols and criteria have not been established. It remains unclear how cardiologists diagnose HFpEF by in real-world practice. Methods Results An international web-based survey was performed on 87 cardiologists,...